Results 41 to 50 of about 105,049 (336)

Derivatives Incorporating Acridine, Pyrrole, and Thiazolidine Rings as Promising Antitumor Agents

Molecules, 2023
Derivatives combining acridine, pyrrole, and thiazolidine rings have emerged as promising candidates in the field of antitumor drug discovery. This paper aims to highlight the importance of these three structural motifs in developing potent and selective
Monika Garberová, Ivan Potočňák, Monika Tvrdoňová, Monika Majirská, Martina Bago-Pilátová, Slávka Bekešová, Andrej Kováč, Peter Takáč, Krutika Khiratkar, Zuzana Kudličková, Ján Elečko, Mária Vilková   +11 more
doaj   +1 more source

Pyrrole-containing hybrids as potential anticancer agents: An insight into current developments and structure-activity relationships.

European journal of medicinal chemistry
Cancer poses a significant threat to human health. Therefore, it is urgent to develop potent anti-cancer drugs with excellent inhibitory activity and no toxic side effects.
Li Long, Han Zhang, Zhihui Zhou, Lei Duan, Dang Fan, Ran Wang, Shan Xu, Dan Qiao, Wu-Fu Zhu   +8 more
semanticscholar   +1 more source

The first direct synthesis of β-unsubstituted meso-decamethylcalix[5]pyrrole

Beilstein Journal of Organic Chemistry, 2009
The first direct synthesis of β-unsubstituted meso-decamethylcalix[5]pyrrole from pyrrole and acetone, with moderate yield, is described. The results showed that a bismuth salt was necessary to obtain calix[5]pyrrole, with the best results obtained using
Luis Chacón-García, Lizbeth Chávez, Denisse R. Cacho, Josue Altamirano-Hernández   +3 more
doaj   +1 more source

Pyrroles as Privileged Scaffolds in the Search for New Potential HIV Inhibitors

Pharmaceuticals, 2021
Acquired immunodeficiency syndrome (AIDS) is caused by human immunodeficiency virus (HIV) and remains a global health problem four decades after the report of its first case.
Maria da Conceição Avelino Dias Bianco, Debora Inacio Leite Firmino Marinho, Lucas Villas Boas Hoelz, Monica Macedo Bastos, Nubia Boechat   +4 more
doaj   +1 more source

Spiroheterocyclization of Methyl 1-Aryl-3-cinnamoyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates by the Action of 3-(Arylamino)-1H-inden-1-ones

Molecules, 2012
Methyl 1-aryl-3-cinnamoyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates interact with 3-(arylamino)-1H-inden-1-ones to give the corresponding 1,1'-diaryl-3'-cinnamoyl-4'-hydroxy-1H-spiro[indeno[1,2-b]pyrrole-3,2'-pyrrole]-2,4,5'
Аndrey N. Maslivets, Pavel A. Slepukhin, Valeriy O. Filimonov, Pavel S. Silaichev   +3 more
doaj   +1 more source

Synthesis of N-perfluoroalkyl-3,4-disubstituted pyrroles by rhodium-catalyzed transannulation of N-fluoroalkyl-1,2,3-triazoles with terminal alkynes

Beilstein Journal of Organic Chemistry, 2021
The rhodium-catalyzed transannulation of N-perfluoroalkyl-1,2,3-triazoles with aromatic and aliphatic terminal alkynes under microwave heating conditions afforded N-perfluoroalkyl-3,4-disubstituted pyrroles (major products) and N-fluoroalkyl-2,4 ...
Olga Bakhanovich, Viktor Khutorianskyi, Vladimir Motornov, Petr Beier   +3 more
doaj   +1 more source

Rapid Assembly of Pyrrole-Ligated 1,3,4-Oxadiazoles and Excellent Antibacterial Activity of Iodophenol Substituents

Molecules, 2023
Pyrrole-ligated 1,3,4-oxadiazole is a very important pharmacophore which exhibits broad therapeutic effects such as anti-tuberculosis, anti-epileptic, anti-HIV, anti-cancer, anti-inflammatory, antioxidant, and antibacterial activities. A one-pot Maillard
Hyein Kim, Lina Gu, Huisu Yeo, Umji Choi, Chang-Ro Lee, Haiyang Yu, Sangho Koo   +6 more
doaj   +1 more source

Calix[3]pyrrole : A Missing Link in Porphyrin-Related Chemistry [PDF]

, 2021
A long-standing question in porphyrin chemistry is why pyrrole monomers selectively form tetrapyrrolic macrocycles, whereas the corresponding tripyrrolic macrocycles are never observed. Calix[3]pyrrole, a tripyrrolic porphyrinogen-like macrocycle bearing
Osuka, Atsuhiro, Yoneda, Tomoki, Nomata, Yu, Inaba, Yuya, Ide, Yuki, Pirillo, Jenny, Inokuma, Yasuhide, Hijikata, Yuh, Sessler, Jonathan L., Yasuhide Inokuma, Yu Nomata, Jenny Pirillo, Tomoki Yoneda, Yuki Ide, Jonathan L. Sessler, Yuya Inaba, Atsuhiro Osuka, Yuh Hijikata   +17 more
core   +1 more source

THEORETICAL CALCULATIONS ABOUT THE THERMAL STABILITY AND DETONATION CHARACTER OF NITRAMINO-SUBSTITUTED PYRROLE

Química Nova
A series of nitramino-derivatives of pyrrole were designed through introducing the nitramino group into pyrrole ring to look for high-energy-density compounds.
Butong Li, Lulin Li, Yu Wang
doaj   +1 more source

Functionalization of Single and Multi-Walled Carbon Nanotubes with Polypropylene Glycol Decorated Pyrrole for the Development of Doxorubicin Nano-Conveyors for Cancer Drug Delivery

Nanomaterials, 2020
A recently reported functionalization of single and multi-walled carbon nanotubes, based on a cycloaddition reaction between carbon nanotubes and a pyrrole derived compound, was exploited for the formation of a doxorubicin (DOX) stacked drug delivery ...
Chiara Pennetta, Giuseppe Floresta, Adriana Carol Eleonora Graziano, Venera Cardile, Lucia Rubino, Maurizio Galimberti, Antonio Rescifina, Vincenzina Barbera   +7 more
doaj   +1 more source