Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Carcinogenesis by Modulating Microtubule-Associated Serine/Threonine Kinase-like/Wnt/β-Catenin Signaling [PDF]
Cells, 2023 Background: Despite significant progress in clinical management, colorectal cancer (CRC) remains the third most common cause of cancer-related deaths.
Raju Lama Tamang +10 more
doaj +3 more sources
Proline metabolism is essential for alkaline adaptation of Nile tilapia (Oreochromis niloticus) [PDF]
Journal of Animal Science and BiotechnologyBackground Saline-alkaline water aquaculture has become a key way to mitigate the reduction of freshwater aquaculture space and meet the increasing global demand for aquatic products. To enhance the comprehensive utilization capability of saline-alkaline
Minxu Wang +6 more
doaj +2 more sources
Proline, Cysteine and Branched-Chain Amino Acids in Abiotic Stress Response of Land Plants and Microalgae. [PDF]
Plants (Basel), 2023 Proteinogenic amino acids are the building blocks of protein, and plants synthesize all of them. In addition to their importance in plant growth and development, growing evidence underlines the central role played by amino acids and their derivatives in ...
Ingrisano R +4 more
europepmc +3 more sources
Expanding the repertoire of imine reductases by mining divergent biosynthetic pathways for promiscuous reactivity. [PDF]
Chem CatalImine reductases (IREDs) are invaluable catalysts for enantioselective imine reduction and reductive amination of carbonyl compounds. Their synthetic versatility is, however, limited by their substrate scope, and new IREDs are needed.
Aleku GA, Hollfelder F.
europepmc +3 more sources
Evolution of plant δ1-pyrroline-5-carboxylate reductases from phylogenetic and structural perspectives [PDF]
Frontiers in Plant Science, 2015 Proline plays a crucial role in cell growth and stress responses, and its accumulation is essential for the tolerance of adverse environmental conditions in plants. Two routes are used to biosynthesize proline in plants.
Giuseppe eForlani +4 more
doaj +4 more sources
Frontiers in Plant Science, 2023 Soil salinity is a major factor threatening the production of crops around the world. Smooth bromegrass (Bromus inermis L.) is a high-quality grass in northern and northwestern China.
Wenxue Song +14 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 In certain cancers, such as breast, prostate and some lung and skin cancers, the gene for the enzyme catalysing the second and last step in proline synthesis, δ1-pyrroline-5-carboxylate (P5C) reductase, has been found upregulated.
Giuseppe Forlani +4 more
doaj +1 more source
Representational Difference Analysis of Transcripts Involved in Jervine Biosynthesis
Life, 2020 Veratrum-type steroidal alkaloids (VSA) are the major bioactive ingredients that strongly determine the pharmacological activities of Veratrum nigrum. Biosynthesis of VSA at the molecular and genetic levels is not well understood.
Magdalena Szeliga +2 more
doaj +1 more source
On the diversity of F420 -dependent oxidoreductases:A sequence- and structure-based classification [PDF]
, 2021 The F(420) deazaflavin cofactor is an intriguing molecule as it structurally resembles the canonical flavin cofactor, although behaves as a nicotinamide cofactor due to its obligate hydride‐transfer reactivity and similar low redox potential.
Fraaije, Marco W +2 more
core +2 more sources
Aldo-keto reductase-1 (AKR1) protect cellular enzymes from salt stress by detoxifying reactive cytotoxic compounds [PDF]
, 2017 Cytotoxic compounds like reactive carbonyl compounds such as methylglyoxal (MG), melandialdehyde (MDA), besides the ROS accumulate significantly at higher levels under salinity stress conditions and affect lipids and proteins that inhibit plant growth ...
Amarnatha Reddy, V. +5 more
core +1 more source