New Trends and Future Opportunities in the Enzymatic Formation of C-C, C-N, and C-O bonds [PDF]
, 2022 Organic chemistry provides society with fundamental products we use daily. Concerns about the impact that the chemical industry has over the environment is propelling major changes in the way we manufacture chemicals.
Mangas-Sanchez, J. +3 more
core +1 more source
Functional specialization in proline biosynthesis of melanoma.
PLoS ONE, 2012 Proline metabolism is linked to hyperprolinemia, schizophrenia, cutis laxa, and cancer. In the latter case, tumor cells tend to rely on proline biosynthesis rather than salvage.
Jessica De Ingeniis +10 more
doaj +1 more source
Kinetics of human pyrroline-5-carboxylate reductase in L-thioproline metabolism. [PDF]
Amino Acids, 2021 L-Thioproline (L-thiazolidine-4-carboxylate, L-T4C) is a cyclic sulfur-containing analog of L-proline found in multiple kingdoms of life. The oxidation of L-T4C leads to L-cysteine formation in bacteria, plants, mammals, and protozoa. The conversion of L-T4C to L-Cys in bacterial cell lysates has been attributed to proline dehydrogenase and L-Δ1 ...
Patel SM +4 more
europepmc +3 more sources
The comER Gene Plays an Important Role in Biofilm Formation and Sporulation in both Bacillus subtilis and Bacillus cereus [PDF]
, 2016 Bacteria adopt alternative cell fates during development. In Bacillus subtilis, the transition from planktonic growth to biofilm formation and sporulation is controlled by a complex regulatory circuit, in which the most important event is activation of ...
Fang Yan +5 more
core +1 more source
Metabolic Origin, Role and Fate of the Denaturant Guanidine. [PDF]
Microb BiotechnolThe origin of metabolic guanidine is largely a mystery. We suggest it is created when guanine‐containing nucleotides are oxidised by molecular oxygen instead of being broken down into urea as purines normally would. Guanidine may act as a signal to help cells control the level of reactive oxygen species.
Danchin A +3 more
europepmc +2 more sources
Selenocysteine, pyrrolysine and the unique energy metabolism of methanogenic archaea [PDF]
, 2010 Methanogenic archaea are a group of strictly anaerobic microorganisms characterized by their strict dependence on the process of methanogenesis for energy conservation.
Rother, Michael, Krzycki, Joseph A.
core +1 more source
Biotechnological approaches to study plant responses to stress [PDF]
, 2013 Multiple biotic and abiotic environmental stress factors affect negatively various aspects of plant growth, development, and crop productivity. Plants, as sessile organisms, have developed, in the course of their evolution, efficient strategies of ...
Gomez-Cadenas, Aurelio +5 more
core +4 more sources
Proline metabolism shapes the tumor microenvironment: from collagen deposition to immune evasion [PDF]
, 2023 Proline is a nonessential amino acid, and its metabolism has been implicated in numerous malignancies. Together with a direct role in regulating cancer cells' proliferation and survival, proline metabolism plays active roles in shaping the tumor ...
Alessandro Rufini +2 more
core +1 more source
Developmental Regulation of Pyrroline-5-Carboxylate Reductase Gene Expression in Arabidopsis [PDF]
Plant Physiology, 1997 Abstract At-P5R, a gene encoding the last enzyme of the proline (Pro) biosynthetic pathway in Arabidopsis thaliana, is developmentally regulated. To characterize the cis elements responsible for this developmental regulation, a series of 5[prime] deletions of the At-P5R promoter were transcriptionally fused to a β-glucuronidase (GUS ...
Hua, Xue-Jun +3 more
openaire +2 more sources
The Proline Regulatory Axis and Cancer [PDF]
, 2012 Studies in metabolism and cancer have characterized changes in core pathways involving glucose and glutamine, emphasizing the provision of substrates for building cell mass.
Christian, Kyle J. +3 more
core +2 more sources