Results 31 to 40 of about 1,126 (165)

Pyrroline-5-Carboxylate Reductase in Lactating Bovine Mammary Glands

Journal of Dairy Science, 1996
The occurrence and subcellular distribution of pyrroline-5-carboxylate reductase have been studied in lactating bovine mammary glands. The enzyme appears to have only a cursory association with the mitochondrial fraction, because significant amounts of the enzyme are found in other membrane-containing fractions and in the cytosol.
J J, Basch, E D, Wickham, H M, Farrell
openaire   +2 more sources

Proteome-wide analysis of Trypanosoma cruzi exponential and stationary growth phases reveals a subcellular compartment-specific regulation [PDF]

, 2018
Trypanosoma cruzi, the etiologic agent of Chagas disease, cycles through different life stages characterized by defined molecular traits associated with the proliferative or differentiation state. In particular, T. cruzi epimastigotes are the replicative
Avila, Carla Cristi, Barisón, María Julia, Costa-Martins, André Guillherme, de Oliveira, Gilberto Santos, Marinho, Claudio Romero Farias, Mule, Simon Ngao, Palmisano, Giuseppe, Rosa-Fernandes, Livia, Silber, Ariel Mariano, Teixeira, Marta Maria Geraldes, Viner, Rosa   +10 more
core   +3 more sources

Characterization of Two Distinct Structural Classes of Selective Aldehyde Dehydrogenase 1A1 Inhibitors. [PDF]

, 2015
Aldehyde dehydrogenases (ALDH) catalyze the irreversible oxidation of aldehydes to their corresponding carboxylic acid. Alterations in ALDH1A1 activity are associated with such diverse diseases as cancer, Parkinson?s disease, obesity, and cataracts ...
Hurley, Thomas D., Morgan, Cynthia A.
core   +1 more source

Asymmetric Synthesis of N‐Substituted α‐Amino Esters from α‐Ketoesters via Imine Reductase‐Catalyzed Reductive Amination [PDF]

, 2021
N‐Substituted α‐amino esters are widely used as chiral intermediates in a range of pharmaceuticals. Here we report the enantioselective biocatalyic synthesis of N‐substituted α‐amino esters through the direct reductive coupling of α‐ketoesters and amines
Charnock, Simon J., Lim, Jesmine, Marshall, James R., Turner, Nicholas J., Xu, Zefei, Yao, Peiyuan, Zhu, Dunming   +6 more
core   +1 more source

Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism [PDF]

, 2013
7-carboxy-7-deazaguanine synthase (QueE) catalyzes a key S-adenosyl-L-methionine (AdoMet)- and Mg[superscript 2+]-dependent radical-mediated ring contraction step, which is common to the biosynthetic pathways of all deazapurine-containing compounds. QueE
A Chatterjee, A Goldman, A Teplyakov, Anthony P Young, AT Brunger, AT Brünger, C Paraskevopoulou, C Romier, C Vonrhein, Catherine L Drennan, CE Farrar, CS Bond, CT Lopes, Daniel P Dowling, DE Blair, DJ Neidhart, DP Dowling, EN Marsh, F Berkovitch, G Layer, GF Schröder, H Takagi, H Walden, H Zheng, HJ Sofia, J Cheek, J Frazzon, J Painter, J Painter, JL Vey, JL Vey, K Huang, KA Shisler, KS Duschene, L Holm, MD Winn, MM Gromiha, MM Harding, N Nagano, N Shibata, NA Baker, Nathan A Bruender, P Emsley, PA Frey, PA Frey, PD Adams, PJ Goldman, RA Laskowski, Reid M McCarty, RM McCarty, RM McCarty, RM McCarty, S French, SC-H Pegg, SE McGlynn, T Kamachi, T Toraya, TC Terwilliger, Vahe Bandarian, Z Otwinowski   +59 more
core   +2 more sources

Omics profiling identifies the regulatory functions of the MAPK/ERK pathway in nephron progenitor metabolism [PDF]

, 2022
Publisher Copyright: © 2022. Published by The Company of Biologists Ltd.Nephron endowment is defined by fetal kidney growth and crucially dictates renal health in adults.
Escande-Beillard, Nathalie, Iaroshenko, Vladislav, Jin, Xing, Kurtzeborn, Kristen, Kuure, Satu, Kwon, Hyuk Nam, Loh, Abigail, Park, Sunghyouk, Reversade, Bruno   +8 more
core   +2 more sources

Transcriptome and proteome dynamics in chemostat culture reveal how Campylobacter jejuni modulates metabolism, stress responses and virulence factors upon changes in oxygen availability [PDF]

, 2017
Campylobacter jejuni, the most frequent cause of food-borne bacterial gastroenteritis worldwide, is a microaerophile that has to survive high environmental oxygen tensions, adapt to oxygen limitation in the intestine and resist host oxidative attack ...
Al-Haideri, Alexeeva, Asif, Atack, Atack, Bingham-Ramos, Butcher, Crack, Dufour, Flint, Flint, Gaynor, Goodhew, Guccione, Guccione, Gundogdu, Hendrixson, Hitchcock, Hofreuter, Holmes, Hwang, Ishihama, Jackson, Javed, Kelly, Kendall, Khademian, Krieg, Lee, Leon-Kempis, Liu, Liu, Liu, Luethy, Luethy, Mahdavi, Maloy, Moser, Nesvizhskii, O'Brien, Oh, Parkhill, Partridge, Pei, Pirt, Pittman, Py, Rasmussen, Rodrigues, Sanguinetti, Seaver, Sellars, Shaw, Sheppard, Spanning, Stel, Stel, Sulaeman, Thomas, Vorwerk, Wang, Weerakoon, Weingarten, Weingarten, Woodall, Wösten, Zhou   +66 more
core   +1 more source

Dye-Linked Flavin-Containing Dehydrogenase from Bacteria Related to Plant [PDF]

, 2018
The so-called dye-linked dehydrogenases catalyze the oxidation of various biomolecules in the presence of an artificial electron acceptor, in which several unique compounds related to plants as substrates such as opine(s) and L-hydroxyproline are ...
Watanabe, Seiya
core   +1 more source

Functional Impact of a Cancer-Related Variant in Human Δ\u3csup\u3e1\u3c/sup\u3e‑Pyrroline-5-Carboxylate Reductase 1 [PDF]

, 2023
Pyrroline-5-carboxylate reductase (PYCR) is a proline biosynthetic enzyme that catalyzes the NAD(P)H-dependent reduction of Δ1-pyrroline-5-carboxylate (P5C) to proline.
Becker, Donald F., Daudu, Oseeyi I., Meeks, Kaylen R., Seravalli, Javier, Tanner, John J., Zhang, Lu   +5 more
core  

Functional properties and structural characterization of rice δ1-pyrroline-5-carboxylate reductase [PDF]

Frontiers in Plant Science, 2015
The majority of plant species accumulate high intracellular levels of proline to cope with hyperosmotic stress conditions. Proline synthesis from glutamate is tightly regulated at both the transcriptional and the translational levels, yet little is known about the mechanisms for post-translational regulation of the enzymatic activities involved.
FORLANI, Giuseppe, BERTAZZINI, Michele, Zarattini, Marco, Funck, Dietmar, Ruszkowski, Milosz, Nocek, Bogusław   +5 more
openaire   +6 more sources