Results 51 to 60 of about 1,126 (165)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, Volume 20, Issue 2, Page 447-463, February 2026.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

2022 Huskies Showcase Schedule and Abstracts [PDF]

, 2022
The 2022 Huskies Showcase booklet includes: Schedule of events Listing of all student presentations by title, Our Husky Compact dimension, student presenter(s), faculty mentor(s), and abstract code Student project ...
St. Cloud State University
core   +1 more source

A short peptide derived from late embryogenesis abundant proteins enhances acid tolerance in Escherichia coli via modulation of two‐component regulatory systems

The FEBS Journal, Volume 293, Issue 3, Page 781-805, February 2026.
Expression of the LEA‐K peptide in E. coli BL21 (DE3) improved bacterial viability under acidic stress (pH4), suggesting a protective function. RNA‐sequencing of LEA‐K‐expressing vs. non‐expressing cells revealed 283 differentially expressed genes (DEGs). In silico docking linked LEA‐K to two‐component systems (TCS) proteins (Rcs, BtsS/R, and EnvZ/OmpR)
Khaled Metwally, Shinya Ikeno
wiley   +1 more source

Global transcriptome analysis of AtPAP2--overexpressing Arabidopsis thaliana with elevated ATP [PDF]

, 2013
BACKGROUND: AtPAP2 is a purple acid phosphatase that is targeted to both chloroplasts and mitochondria. Over-expression (OE) lines of AtPAP2 grew faster, produced more seeds, and contained higher leaf sucrose and glucose contents. The present study aimed
Liang, C, Lim, BL, Sun, F, Whelan, J, Yang, J, Zhang, P   +5 more
core   +2 more sources

Genome‐Wide Association Study and RNA Sequencing Identify Candidate Genes Regulating Nitrogen Use Efficiency and Associated Traits in Sorghum (Sorghum bicolor (L.) Moench)

Food and Energy Security, Volume 15, Issue 1, January/February 2026.
ABSTRACT Sorghum (Sorghum bicolor L. Moench) is a resilient cereal crop with remarkable adaptability to diverse environments. Nitrogen use efficiency (NUE) is critical for improving sorghum yields, resource utilization, livelihood security, and environmental sustainability of the target ecologies.
Srikanth Bollam, Laavanya Rayaprolu, Kirandeep Kaur Romana, Pradeep Ruperao, Sivasubramani Selvanayagam, Anil Kumar Vemula, Gopikrishna Adapala, Vinod Kumar Valluri, Prasad Bajaj, Abhishek Rathore, Damaris A. Odeny, Rakesh K. Srivastava, Santosh P. Deshpande, Rajeev Gupta   +13 more
wiley   +1 more source

Perspectives on deciphering mechanisms underlying plant heat stress response and thermotolerance [PDF]

, 2013
Global warming is a major threat for agriculture and food safety and in many cases the negative effects are already apparent. The current challenge of basic and applied plant science is to decipher the molecular mechanisms of heat stress response (HSR ...
Bokszczanin, Kamila L., Fragkostefanakis, Sotirios   +1 more
core  

Transcriptional Analysis and Genome‐Wide Identification of HA, FRO, and IRT Gene Families Reveal Key Regulators in Pear Seedlings to Short‐Term Iron Deficiency Stress

Food and Energy Security, Volume 15, Issue 1, January/February 2026.
ABSTRACT Iron (Fe) is an essential micronutrient for plant photosynthesis and human health. Pear represents a widely consumed fruit for human Fe intake, yet its yield and quality are frequently challenged by Fe deficiency (FD) stress. Despite the prevalence of FD stress in agricultural production under generally alkaline and calcareous conditions, pear
Guoling Guo, Haoguo Liu, Le Xu, Xinxin Wang, Mengxue Xia, Zhiwen Gao, Lun Liu, Wei Heng, Zhenfeng Ye, Li Liu, Bing Jia, Xiaomei Tang   +11 more
wiley   +1 more source

Molecular annotation of ketol-acid reductoisomerases fromStreptomycesreveals a novel amino acid biosynthesis interlock mediated by enzyme promiscuity [PDF]

, 2014
The 6-phosphogluconate dehydrogenase superfamily oxidize and reduce a wide range of substrates, making their functional annotation challenging. Ketolacid reductoisomerase (KARI), encoded by the ilvC gene in branched-chain amino acids biosynthesis, is a
Barona Gómez, Francisco, Hodgson, David A., López Cortina, Susana, Verdel Aranda, Karina   +3 more
core   +1 more source

Partial purification and some properties of delta1-pyrroline-5-carboxylate reductase from Escherichia coli [PDF]

Journal of Bacteriology, 1977
delta1-Pyrroline-5-carboxylate (PCA) reductase [L-proline:NAD(P)+5-oxidoreductase, EC 1.5.1.2] has been purified over 200-fold from Escherichia coli K-12. It has a molecular weight of approximately 320,000. PCA reductase mediates the pyridine nucleotide-linked reduction of PCA to proline but not the reverse reaction (even at high substrate ...
J J, Rossi, J, Vender, C M, Berg, W H, Coleman   +3 more
openaire   +2 more sources

PYCR1 Downregulation Induces Autophagy Dependent Apoptosis Through Inhibiting PI3K/AKT/mTOR Axis in Human Hepatocellular Carcinoma Cells

Analytical Cellular Pathology, Volume 2026, Issue 1, 2026.
Background Hepatocellular carcinoma (HCC) is a global malignant tumor type. Pyrroline‐5‐carboxylate reductase 1 (PYCR1) is a metabolic enzyme that exhibits pro‐tumor properties in cancer progression. However, the exact molecular mechanism of PYCR1 in HCC progression is still unclear.
Junli Zhang, Yachao Hou, Xinxin Jin, Biao Gu, Wenjuan Wu, Shih-Min Hsia   +5 more
wiley   +1 more source