Results 61 to 70 of about 1,126 (165)

Multi‐omic data integration and exploiting metabolic models using systems biology approach increase precision in subtyping and early diagnosis of cancer

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Cancer is a complex and heterogeneous disease characterized by various genetic and epigenetic alterations. Early diagnosis, accurate subtyping, and staging are essential for effective, personalized treatment and improved survival rates. Traditional diagnostic methods, such as biopsies, are invasive and carry operational risks that hinder ...
Ezgi Tanıl, Emrah Nikerel
wiley   +1 more source

A broadly applicable artificial selection system for biomolecule evolution [PDF]

, 2020
Biocatalysis offers an attractive alternative to traditional chemical catalysis. However, it is often found that an enzyme with the optimal properties for a specific application is not available within the natural repertoire of enzymes.
Selles Vidal, Lara
core   +1 more source

Lactylation in cancer biology: Unlocking new avenues for research and therapy

Cancer Communications, Volume 45, Issue 11, Page 1367-1406, November 2025.
Abstract Lactylation, a newly identified post‐translational modification, plays a multifaceted role in cancer biology by integrating epigenetic and non‐epigenetic mechanisms. This review summarizes the latest research progress on lactylation, including its functions in epigenetic regulation and its broader impact on cellular processes.
Xiaoyu Hou, Zhenya Hong, Huimin Zeng, Changyi Zhang, Peng Zhang, Ding Ma, Zhiqiang Han   +6 more
wiley   +1 more source

Adaptive Remodeling of the Proteome in Pistachio Roots Under Salt Stress: Implications for Food and Energy Security in Arid Regions

Food and Energy Security, Volume 14, Issue 6, November/December 2025.
Overview of evaluating the effects of NaCl treatment on pistachio rootstock UCB‐1. ABSTRACT Pistachio thrives in semi‐arid and arid environments and is highly adaptable to various abiotic stresses. However, soil salinization significantly threatens productivity, leading to considerable osmotic and ionic stress for these plants.
Mohammad Akbari, Rakesh K. Singh, Elena Andriūnaitė, Umesh Reddy, Mostafa Farajpour, Sanaa Simmons, Dalia Vishnudasan, Sona Charles, Prashanth Suravajhala, Nasser Mahna, Ramesh Katam   +10 more
wiley   +1 more source

Plant-symbiotic fungi as chemical engineers: multi-genome analysis of the Clavicipitaceae reveals dynamics of alkaloid Loci [PDF]

, 2013
The fungal family Clavicipitaceae includes plant symbionts and parasites that produce several psychoactive and bioprotective alkaloids. The family includes grass symbionts in the epichloae clade (Epichloë and Neotyphodium species), which are ...
A Dereeper, A Krogh, A Leuchtmann, A Markert, A Tanaka, AA Bacetty, AA Salamov, Adrian Leuchtmann, AJ Clutterbuck, AJ Enright, Anar K. Khan, Anna Gordon, Anthony E. Glenn, B Ewing, Barry Scott, Birgitt Oeser, BJ Blaney, BL Cantarel, BL Kutil, Bruce A. Roe, BS Margolin, C Young, C Young, CA Cuomo, CA Young, CA Young, Caroline Machado, Carolyn A. Young, Charles T. Bullock, Christine R. Voisey, Christopher L. Schardl, Chunjie Li, CJ Eaton, CL Schardl, CL Schardl, CL Schardl, CL Schardl, CL Schardl, CM Coyle, D-X Zhang, D-X Zhang, Damien J. Fleetwood, Daniel G. Panaccione, Daniel R. Harris, David C. Haws, DG Panaccione, DG Panaccione, DJ Fleetwood, DJ Fleetwood, Donal M. O'Sullivan, DP Malinowski, E Tanaka, Eckhard Leistner, Eiji Tanaka, Elissaveta G. Arnaoudova, Ella V. Wilson, F Chen, G Mey, GCM Latch, GE Tusnády, GH Sung, H Shimodaira, H Svardal, H-F Tsai, HG Knaus, I Masami, J Jurka, J Tor-Agbidye, J Wang, JA Rudgers, Jan Schmid, Jennifer L. Wiseman, Jennifer S. Webb, Jerzy W. Jaromczyk, JH Bouton, JinGe Liu, Jinze Liu, JL Cenis, Johanna E. Takach, Jolanta Jaromczyk, Joseph Heitman, JR Faulkner, Juan Pan, JW Spatafora, K Clay, K Urga, K Wang, K-R Chung, Kalina Andreeva, Kathryn K. Schweri, Koya Sugawara, KP Schliep, L Li, LD Stein, Li Chen, LJ Iannone, LR Caporael, M Anisimova, M Freitag, M Pava-Ripoll, M Stanke, Mark L. Farman, ME Afkhami, MG Kidwell, Miao Liu, MJ Eadie, MJ Spiering, MJ Spiering, MJ Spiering, MJ Spiering, ML Farman, MM Smith, Murray Cox, N Castagnoli Jr, N Lorenz, N Lorenz, N Lorenz, Neil Moore, Nikki D. Charlton, P Scott, P Tudzynski, Padmaja Nagabhyru, Patrick J. Calie, Paul Tudzynski, PC Lyons, PG Crosignani, PW Ewald, Q Gao, R Chenna, R Edgar, R Jothi, Randy D. Dinkins, RC Edgar, Richard D. Johnson, RJ Cole, RKA Giger, RM Andrie, RT Gallagher, Ruriko Yoshida, RW Thompson, S Guindon, S Huse, S Pažoutová, S Rasmussen, S Saari, S Saikia, S Saikia, S Saikia, S Uhlig, SF Altschul, Simona Florea, SM Li, Stefan G. Amyotte, T Haarmann, T Haarmann, T Philippi, T Rouxel, TH Al-Samarrai, U Steiner, U Steiner, Uljana Hesse, Ulrich Güldener, Ulrike Steiner, V Ter-Hovhannisyan, W Wiesemuller, Wade Mace, Walter Hollin, WM Gao, YY Zhu, Z-q An, Zheng Zeng, Zhiqiang An   +171 more
core   +4 more sources

Identity of proline dehydrogenase and delta1-pyrroline-5-carboxylic acid reductase in Clostridium sporogenes [PDF]

Journal of Bacteriology, 1978
Proline dehydrogenase and delta1-pyrroline-5-carboxylic acid (PCA) reductase activities were copurified 60- and 130-fold, respectively, from extracts of Clostridium sporogenes. The primary change in the ratio of activites was the result of a loss of proline dehydrogenase activity during dialysis.
R N, Costilow, D, Cooper
openaire   +2 more sources

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, Volume 103, Issue 7, Page e436-e455, November 2025.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source

Mitochondria‐Associated Endoplasmic Reticulum Membranes in Health and Diseases

MedComm, Volume 6, Issue 10, October 2025.
As pivotal regulators in diverse physiological and pathological processes, mitochondria‐associated endoplasmic reticulum membranes (MAMs) are critically involved in both health and diseases, including cancers, neurodegenerative disorders, metabolic diseases, cardiovascular diseases.
Hangnan Hong, Zhenyang Guo, Junbo Ge, Hua Li   +3 more
wiley   +1 more source

The loss of the urea cycle and ornithine metabolism in different insect orders: An omics approach

Insect Molecular Biology, Volume 34, Issue 5, Page 632-644, October 2025.
Among urea cycle enzymes, only the nitric oxide synthase gene is universally present across insect genomes. All Hemiptera species lack the enzymes needed to convert citrulline to arginine, and some also lack the pathway from arginine to ornithine. Putrescine and spermidine synthesis is conserved in all insects, but aphids lack the capability to produce
Jessica Cristina Silva Martins, Héctor Antônio Assunção Romão, Carolina Kurotusch Canettieri, Amanda Caetano Cercilian, Patrícia Rasteiro Ordiale Oliveira, Clelia Ferreira, Walter R. Terra, Renata de Oliveira Dias   +7 more
wiley   +1 more source

Apolipoprotein M (ApoM) Ameliorates Acute Alcohol Intoxication (AAI)‐Hemorrhagic Shock and Resuscitation (HSR)‐Induced Microvascular Leakage

Microcirculation, Volume 32, Issue 7, October 2025.
ABSTRACT Objective Microvascular hyperpermeability is a serious complication that occurs from hemorrhagic shock and resuscitation (HSR), especially when combined with acute alcohol intoxication (AAI). We tested the hypothesis that administration of Apolipoprotein M (ApoM), a lipocalin that normally resides in plasma high‐density lipoproteins (HDL) and ...
Mengmeng Chang, Jerome W. Breslin
wiley   +1 more source