Results 271 to 280 of about 145,153 (320)

Thiamin diphosphate dependent enzymes: transketolase, pyruvate oxidase and pyruvate decarboxylase

Current Opinion in Structural Biology, 1993
Abstract The past few years have brought significant advances in our understanding of thiamin diphosphate dependent enzymes. The determination of the three-dimensional structures of transketolase, pyruvate oxidase and pyruvate decarboxylase has revealed a common thiamin-binding fold and provided the first structural insights into enzymatic thiamin ...
Gunter Schneider, Ylva Lindqvist
openaire   +2 more sources

Conversion of pyruvate decarboxylase into an enantioselective carboligase with biosynthetic potential.

Journal of the American Chemical Society, 2011
Pyruvate decarboxylase (PDC) catalyzes the decarboxylation of pyruvate into acetaldehyde and CO(2) and requires the cofactors thiamin diphosphate and Mg(2+) for activity. Owing to its catalytic promiscuity and relaxed substrate specificity, PDC catalyzes
Danilo Meyer, Lydia S. Walter, G. Kolter, M. Pohl, Michael Müller, K. Tittmann   +5 more
semanticscholar   +1 more source

Pyruvate Decarboxylase:  A Molecular Modeling Study of Pyruvate Decarboxylation and Acyloin Formation

Journal of the American Chemical Society, 1996
Using crystal structure data for the pyruvate decarboxylase from Saccharomyces uvarum (which is nearly identical with the enzyme from Saccharomyces cerevisiae), molecular modeling studies have been carried out to investigate the mode of action of the enzyme. Each step of the decarboxylation mechanism can be explained by assuming that the 4‘-amino group
David H. G. Crout, Mario Lobell
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Pyruvate Decarboxylase Deficiency in Subacute Necrotizing Encephalomyelopathy

Archives of Neurology, 1981
A partial deficiency of pyruvate decarboxylase (PDC) was demonstrated in a child with hyperlactatemia and progressive ataxia, bulbar paresis, ophthalmoplegia, and polyneuropathy. Subacute necrotizing encephalomyelopathy (SNE) was found at necropsy. The association of SNE and PDC deficiency has been reported rarely, but a review of the diverse metabolic
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Phenazine Methosulphate as a Mediator in the Oxidation of Pyruvate by Pyruvate Decarboxylase from Brewer's Yeast

Nature, 1960
PURIFIED pyruvate decarboxylase from brewer's yeast1 is not only capable of decarboxylating pyruvate to acetaldehyde and carbon dioxide2, but can also catalyse the oxidation of pyruvate to acetate with 2,6-dichlorophenolindophenol as artificial hydrogen acceptor3.
Helmut Holzer, R. M. M. Crawford
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Maize pyruvate decarboxylase mRNA is induced anaerobically

Plant Molecular Biology, 1989
A cDNA was identified using an oligonucleotide designed by comparing the sequences of bacterial and yeast pyruvate decarboxylase. The sequence of the cDNA identified by the oligonucleotide contained an open reading frame that encoded a protein of 65 kDa that was similar in sequence to bacterial and yeast pyruvate decarboxylase.
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pyruvate decarboxylase

Catalysis from A to Z, 2020

semanticscholar   +1 more source

Breeding of high-pyruvate-producing Torulopsis glabrata with acquired reduced pyruvate decarboxylase

Journal of Bioscience and Bioengineering, 1999
An efficient method for isolation of pyruvate-producing mutants of Torulopsis glabrata IFO 0005 was established. On mutagenesis of the parent strain, mutants requiring acetate for complete growth were isolated. The acetate-leaky auxotrophic mutants demonstrated higher fermentative yields of pyruvate from glucose than the parent strain.
Tetsu Yonehara, Reiko Miyata
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indole‐3‐pyruvate decarboxylase

Catalysis from A to Z, 2020

semanticscholar   +1 more source

Pyruvate decarboxylase in photosynthetic bacteria

Biochimica et Biophysica Acta (BBA) - General Subjects, 1967
D.S. Hoare, Quadri Sm
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