Results 1 to 10 of about 114,088 (211)

Construction of an in vitro bypassed pyruvate decarboxylation pathway using thermostable enzyme modules and its application to N-acetylglutamate production. [PDF]

Microb Cell Fact, 2013
BackgroundMetabolic engineering has emerged as a practical alternative to conventional chemical conversion particularly in biocommodity production processes.
Krutsakorn B, Imagawa T, Honda K, Okano K, Ohtake H.   +4 more
europepmc   +4 more sources

Decarboxylation of Pyruvate to Acetaldehyde for Ethanol Production by Hyperthermophiles [PDF]

Biomolecules, 2013
Pyruvate decarboxylase (PDC encoded by pdc) is a thiamine pyrophosphate (TPP)-containing enzyme responsible for the conversion of pyruvate to acetaldehyde in many mesophilic organisms.
Mohammad S. Eram, Kesen Ma
doaj   +3 more sources

Oxidative decarboxylation of pyruvate by 1-deoxy-d-xyulose 5-phosphate synthase, a central metabolic enzyme in bacteria [PDF]

Journal of Biological Chemistry, 2018
The underexploited antibacterial target 1-deoxy-d-xyluose 5-phosphate (DXP) synthase catalyzes the thiamin diphosphate (ThDP)-dependent formation of DXP from pyruvate and d-glyceraldehyde 3-phosphate (d-GAP).
Alicia A. DeColli, Natalia S. Nemeria, Ananya Majumdar, Gary J. Gerfen, Frank Jordan, Caren L. Freel Meyers   +5 more
openalex   +2 more sources

Phosphoenolpyruvate Carboxykinase Is Involved in the Decarboxylation of Aspartate in the Bundle Sheath of Maize1 [PDF]

, 1999
We recently showed that maize (Zea mays L.) leaves contain appreciable amounts of phosphoenolpyruvate carboxykinase (PEPCK; R.P. Walker, R.M. Acheson, L.I. Técsi, R.C. Leegood [1997] Aust J Plant Physiol 24: 459–468).
Astrid Wingler, Robert P. Walker, Zhihui Chen, Richard C. Leegood   +3 more
openalex   +5 more sources

Heterogeneous Expression and Subcellular Localization of Pyruvate Dehydrogenase Complex in Prostate Cancer

Frontiers in Oncology, 2022
BackgroundPyruvate dehydrogenase (PDH) complex converts pyruvate into acetyl-CoA by pyruvate decarboxylation, which drives energy metabolism during cell growth, including prostate cancer (PCa) cell growth.
Caroline E. Nunes-Xavier, Caroline E. Nunes-Xavier, Janire Mingo, Maite Emaldi, Karine Flem-Karlsen, Gunhild M. Mælandsmo, Øystein Fodstad, Roberto Llarena, José I. López, José I. López, Rafael Pulido, Rafael Pulido   +11 more
doaj   +2 more sources

A Thiamin-bound, Pre-decarboxylation Reaction Intermediate Analogue in the Pyruvate Dehydrogenase E1 Subunit Induces Large Scale Disorder-to-Order Transformations in the Enzyme and Reveals Novel Structural Features in the Covalently Bound Adduct [PDF]

Journal of Biological Chemistry, 2006
The crystal structure of the E1 component from the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDHc) has been determined with phosphonolactylthiamin diphosphate (PLThDP) in its active site. PLThDP serves as a structural and electrostatic
Palaniappa Arjunan, Martin Sax, Andrew P. J. Brunskill, Krishnamoorthy Chandrasekhar, Natalia S. Nemeria, Sheng Zhang, Frank Jordan, William Furey   +7 more
openalex   +2 more sources

C2-α-Lactylthiamin Diphosphate Is an Intermediate on the Pathway of Thiamin Diphosphate-dependent Pyruvate Decarboxylation

Journal of Biological Chemistry, 2004
Thiamin diphosphate (ThDP)-dependent decarboxylations are usually assumed to proceed by a series of covalent intermediates, the first one being the C2-trimethylthiazolium adduct with pyruvate, C2-α-lactylthiamin diphosphate (LThDP).
Sheng Zhang, Min Liu, Yan Yan, Zhen Zhang, Frank Jordan   +4 more
openalex   +2 more sources

Aqueous pyruvate partly dissociates under deep ultraviolet irradiation but is resilient to near ultraviolet excitation

Nature Communications
The deep ultraviolet photochemistry of aqueous pyruvate is believed to have been essential to the origin of life, and near ultraviolet excitation of pyruvate in aqueous aerosols is assumed to contribute significantly to the photochemistry of the Earth’s ...
Jan Thøgersen, Fani Madzharova, Tobias Weidner, Frank Jensen   +3 more
doaj   +2 more sources

Aldehyde-based Activation of C2α-lactylthiamin Diphosphate Decarboxylation on Bacterial 1-deoxy-d-xylulose 5-phosphate Synthase. [PDF]

Chembiochem
1‐Deoxy‐d‐xylulose 5‐phosphate synthase (DXPS) catalyzes the thiamin diphosphate (ThDP)‐dependent formation of DXP from pyruvate (donor substrate) and d‐glyceraldehyde 3‐phosphate (d‐GAP, acceptor substrate) in bacterial central metabolism.
Toci EM, Majumdar A, Meyers CLF.
europepmc   +2 more sources

miR-1343-3p regulating OGDHL/PDHB-pyruvate glucose metabolic reprogramming against gastric cancer cell proliferation [PDF]

Discover Oncology
Background Gastric cancer (GC) is the main cause for cancer-related mortality in the world. Recent studies have confirmed that metabolic reprogramming plays a significant role in cancer progression.
Xinrui Hou, Zhendong Zhang, Mingyuan Cao, Yuxin Du, Xiaoping Wang   +4 more
doaj   +2 more sources