Results 131 to 140 of about 21,656 (280)

Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells [PDF]

, 2016
Background: Loss of a cell’s capacity to generate sufficient energy for cellular functions is a key hallmark of the ageing process and ultimately leads to a variety of important age-related pathologies such as cancer, Parkinson’s disease and ...
Docherty, Craig K., Mercer, John R., Salt, Ian P.   +2 more
core   +3 more sources

The Essentiality of Amino Acids in Healthiness and Disease State: Type II Diabetes as a Case Study

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
This review investigates the functions of amino acids in normal physiological states, their potential as a diagnostic biomarker, the probable risk of deficiency, and the therapeutic ability for managing and preventing type 2 diabetes mellitus. ABSTRACT A healthy life depends on the availability and the synthesis of amino acids as they are building ...
Samuel Idowu Fayomi, Ochuko Lucky Erukainure, Nontokozo Zimbili Msomi   +2 more
wiley   +1 more source

Characterization of Nuclear Magnetism at Ultralow and Zero Field using SQUIDs [PDF]

IEEE Transactions on Applied Superconductivity, 2025
Nuclear magnetism underpins areas such as medicine in magnetic resonance imaging (MRI). Hyperpolarization of nuclei enhances the quantity and quality of information that can be determined from these techniques by increasing their signal to noise ratios by orders of magnitude. However, some of these hyperpolarization techniques rely on the use of low to
arxiv   +1 more source

Evolutionary analysis of the TPP-dependent enzyme family [PDF]

, 2008
The evolutionary relationships of the thiamine pyrophosphate (TPP)-dependent family of enzymes was investigated by generation of a neighbor joining phylogenetic tree using sequences from the conserved pyrophosphate (PP) and pyrimidine (Pyr) binding ...
Costelloe, S.J., Dalby, P.A., Ward, J.M.
core  

Gold(I)-catalysed synthesis of a furan analogue of thiamine pyrophosphate. [PDF]

, 2014
An analogue of thiamine having a furan ring in place of the thiazolium ring has been synthesised by a short and efficient route, involving gold(I)-catalysed cyclisation of an alkynyl alcohol to form the furan ring.
Iqbal, Amjid, Leeper, Finian J, Sahraoui, El-Habib   +2 more
core   +3 more sources

Post-translational modifications of pyruvate dehydrogenase complex in cardiovascular disease

iScience
Summary: Pyruvate dehydrogenase complex (PDC) is a crucial enzyme that connects glycolysis and the tricarboxylic acid (TCA) cycle pathway. It plays an essential role in regulating glucose metabolism for energy production by catalyzing the oxidative ...
Bo Guo, Fujiao Zhang, Yue Yin, Xingmin Ning, Zihui Zhang, Qinglei Meng, Ziqi Yang, Wenhua Jiang, Manling Liu, Yishi Wang, Lijuan Sun, Lu Yu, Nan Mu   +12 more
doaj  

A Bird's‐Eye View of Glycolytic Upregulation in Activated Brain: The Major Fate of Lactate Is Release From Activated Tissue, Not Shuttling to Nearby Neurons

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
During brain activation triggered by sensory stimulation, mental activity, or physical work, nonoxidative metabolism of glucose (CMRglc‐non‐ox, where subscripts ‐n and ‐a denote the rate in neurons and astrocytes, respectively) and glycogen are disproportionately upregulated compared with the cellular rates of oxidative metabolism of glucose (CMRglc‐ox)
Gerald A. Dienel, Douglas L. Rothman, Silvia Mangia   +2 more
wiley   +1 more source

ChnagG Plays the Role of 5‐Salicylate Hydroxylase in the Gentisic Acid Pathway of Salicylic Acid Metabolism in Cochliobolus heterostrophus

Molecular Plant Pathology, Volume 26, Issue 6, June 2025.
The ChnagG gene in Cochliobolus heterostrophus encodes 5‐salicylate hydroxylase, converting salicylic acid (SA) to gentisic acid, enhancing pathogenicity and suppressing plant SA signalling‐mediated defences during infection. ABSTRACT Salicylic acid (SA) plays a crucial role in the defence strategies of plants against fungal pathogens.
Yadi Xu, He Wei, Haixiao Li, Fanli Zeng, Ning Liu, Zhiyan Cao, Jingao Dong   +6 more
wiley   +1 more source

Guard cell‐specific glycine decarboxylase manipulation affects Arabidopsis photosynthesis, growth and stomatal behavior

New Phytologist, Volume 246, Issue 5, Page 2102-2117, June 2025.
Summary Photorespiration is a mandatory metabolic repair shunt of carbon fixation by the Calvin–Benson cycle in oxygenic phototrophs. Its extent depends mainly on the CO2 : O2 ratio in chloroplasts, which is regulated via stomatal movements. Despite a comprehensive understanding of the role of photorespiration in mesophyll cells, its role in guard ...
Hu Sun, Nils Schmidt, Tracy Lawson, Martin Hagemann, Stefan Timm   +4 more
wiley   +1 more source

Pyruvate decarboxylating action of L-cycloserine. The significance of this in understanding its metabolic inhibitory action.

Journal of Biological Chemistry, 1986
We present evidence which demonstrates that L-cycloserine, structural analog of L-alanine, which is known to be an effective aminotransferase inhibitor, is also a potent inhibitor of cellular pyruvate metabolism. This effect was found to be related to its almost instantaneous action in decreasing pyruvate concentrations in a dose-dependent manner.
Pérez-Sala, Dolores, Cerdán, Sebastián, Ballesteros, Paloma, Sánchez Ayuso, Matilde, Parrilla, Roberto L.   +4 more
openaire   +4 more sources