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Impaired oxidative decarboxylation of pyruvate in fibroblasts from patients with Parkinson's disease
Journal of Neural Transmission - Parkinson's Disease and Dementia Section, 1994 Whether or not a reported deficiency in brain mitochondrial complex I activity in Parkinson's disease represents a defect encompassing other organs or tissues has been a source of some controversy. We have examined mitochondrial respiration in fibroblasts from patients with Parkinson's disease by measuring the oxidative decarboxylation of [2-14C ...
Catherine Mytilineou +5 more
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Journal of the American Chemical Society, 1978 Carbon-13 kinetic isotope effects were determined on pyruvate decarboxylation catalyzed by the enzyme yeast pyruvate decarboxylase and by thiamin, and in CHDT/sup +/Cl/sup -/ (2(1-carboxyl-1-hydroxyethyl)-3,4-dimethylthiazolium chloride). The CHDT/sup +/Cl/sup -/ gave an effect of 1.051 corresponding to the maximum isotope effect anticipated for CO/sub
Frank Jordan, Donald J. Kuo, E. U. Monse
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Carbon-13 and deuterium isotope effects on oxalacetate decarboxylation by pyruvate carboxylase
Biochemistry, 1986 Deuterium and 13C isotope effects for the enzymic decarboxylation of oxalacetate showed that both deuterium- and 13C-sensitive steps in the reaction are partially rate limiting. A normal alpha-secondary effect of 1.2 per deuterium was calculated for the reaction in which pyruvate-d3 was the substrate, suggesting that the enolate of pyruvate was an ...
Paul V. Attwood +2 more
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Pyruvate decarboxylation and its relationship to contraction of cardiac myofibrils
American Journal of Physiology-Legacy Content, 1966 H Diaz de Arce, Lamar Crevasse, JC Shipp
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Decarboxylation of oxalacetate by pyruvate carboxylase
Biochemistry, 1986The decarboxylation of oxalacetate by pyruvate carboxylase in the absence of ADP and Pi is stimulated 400-fold by the presence of oxamate, which is an inhibitory analogue of pyruvate. The observation of substrate inhibition when either oxamate or oxalacetate is varied at a fixed concentration of the other indicates that both molecules bind at the same ...
Paul V. Attwood, W. W. Cleland
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Decarboxylation and carboxylation of pyruvate in the living mice
Biochimie, 1979Mice received intravenously [1- or 2-14C]acetate, [1-, 2- or 3-14C] or [2-14C]pyruvate and were killed 1, 3, 5 or 15 min later. The radioactivity of CO2 or HCO3- of liver or carcass as well as the radioactivity of blood glucose were measured. The ratio of the radioactivity found in these compounds after [3-14C] or [2-14C-A1pyruvate injection suggests ...
P. Favarger, Sylvette Bas, Simonne Rous
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Estimation of pyruvate decarboxylation in perfused rat skeletal muscle
Biochemical and Biophysical Research Communications, 1983By the determination of pyruvate dehydrogenase activity in tissue homogenates only limited information is gained on the actual metabolic flux. We therefore determined pyruvate decarboxylation in isolated rat hindlimbs non recirculating perfused with physiological (1-14C)pyruvate levels.
Peter Schadewaldt +3 more
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Decarboxylation of pyruvic acid in aqueous solution by thermal proteinoids
Archives of Biochemistry and Biophysics, 1968Abstract Thermal proteinoids accelerate the conversion of pyruvic acid to carbon dioxide and acetic acid. The reaction follows Michaelis-Menten kinetics. Co-poly(glutamic acid-threonine) and co-poly (glutamic acid-leucine) were found to be the most active of simple co-polymers and even more active than proteinoid.
Heinrich G. Hardebeck +2 more
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A DFT study of the structures of pyruvic acid isomers and their decarboxylation
Organic & Biomolecular Chemistry, 2006Pyruvic acid and its isomers, including the enol tautomers and enantiomeric lactone structures, have been investigated at the B3LYP/6-311 + + G(3df,3pd) level, and it is found that a keto form with trans C(methyl)C(keto)C(acid)O(hydroxyl) and cis C(keto)C(acid)OH, and with one methyl hydrogen in a synperiplanar position with respect to the keto oxygen,
Mallika Pathak +2 more
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