Results 31 to 40 of about 114,163 (257)

Pyruvate:ferredoxin oxidoreductase and low abundant ferredoxins support aerobic photomixotrophic growth in cyanobacteria

eLife, 2022
The decarboxylation of pyruvate is a central reaction in the carbon metabolism of all organisms. It is catalyzed by the pyruvate:ferredoxin oxidoreductase (PFOR) and the pyruvate dehydrogenase (PDH) complex.
Yingying Wang, Xi Chen, Katharina Spengler, Karoline Terberger, Marko Boehm, Jens Appel, Thomas Barske, Stefan Timm, Natalia Battchikova, Martin Hagemann, Kirstin Gutekunst   +10 more
doaj   +1 more source

Pathogenic mechanisms underlying X-linked Charcot-Marie-Tooth neuropathy (CMTX6) in patients with a pyruvate dehydrogenase kinase 3 mutation

Neurobiology of Disease, 2016
Charcot-Marie-Tooth disease (CMT) is the most common inherited peripheral neuropathy. An X-linked form of CMT (CMTX6) is caused by a missense mutation (R158H) in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene.
Gonzalo Perez-Siles, Carolyn Ly, Adrienne Grant, Alexander P. Drew, Eppie M. Yiu, Monique M. Ryan, David T. Chuang, Shih-Chia Tso, Garth A. Nicholson, Marina L. Kennerson   +9 more
doaj   +1 more source

Insights Into the Carboxyltransferase Reaction of Pyruvate Carboxylase From the Structures of Bound Product and Intermediate Analogs [PDF]

, 2013
Pyruvate carboxylase (PC) is a biotin-dependent enzyme that catalyzes the MgATP- and bicarbonate-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in central metabolism.
Lietzan, Adam D., Maurice, Martin St.
core   +2 more sources

Characteristics of C-4 photosynthesis in stems and petioles of C-3 flowering plants [PDF]

, 2002
Most plants are known as C-3 plants because the first product of photosynthetic CO2 fixation is a three-carbon compound. C-4 plants, which use an alternative pathway in which the first product is a four-carbon compound, have evolved independently many ...
A Ben Zioni, AR Ashton, AR Vuorinen, EA Kinsman, ET Nilsen, J Gerendas, J Schaaf, JA Raven, JA Raven, JC Thomas, JE Keeley, JE Keeley, JM Hibberd, JM Hibberd, JR Reinfelder, JS Pate, K Esau, M Calvin, MD Cramer, MD Cramer, MD Hatch, PD Moore, PJ Lea, RF Sage, RK Monson, RP Walker, S Rawsthorne, S Rawsthorne, S Rawsthorne, Z Gao   +29 more
core   +1 more source

Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications

Bioscience Reports, 2021
Pyruvate dehydrogenase kinase (PDK) can regulate the catalytic activity of pyruvate decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it further links glycolysis with the tricarboxylic acid cycle and ATP generation. This
Xiuxiu Wang, Xiaoyue Shen, Yuting Yan, Hongmin Li   +3 more
semanticscholar   +1 more source

Diisopropylamine dichloroacetate, a novel pyruvate dehydrogenase kinase 4 inhibitor, as a potential therapeutic agent for metabolic disorders and multiorgan failure in severe influenza. [PDF]

PLoS ONE, 2014
Severe influenza is characterized by cytokine storm and multiorgan failure with metabolic energy disorders and vascular hyperpermeability. In the regulation of energy homeostasis, the pyruvate dehydrogenase (PDH) complex plays an important role by ...
Kazuhiko Yamane, Irene L Indalao, Junji Chida, Yoshikazu Yamamoto, Masaaki Hanawa, Hiroshi Kido   +5 more
doaj   +1 more source

Rewiring yeast acetate metabolism through MPC1 loss of function leads to mitochondrial damage and decreases chronological lifespan

Microbial Cell, 2014
During growth on fermentable substrates, such as glucose, pyruvate, which is the end-product of glycolysis, can be used to generate acetyl-CoA in the cytosol via acetaldehyde and acetate, or in mitochondria by direct oxidative decarboxylation.
Ivan Orlandi, Damiano Pellegrino Coppola, Marina Vai   +2 more
doaj   +1 more source

Regulation of pyruvate dehydrogenase complex related to lactate switch in CHO cells

Engineering in Life Sciences, 2021
The metabolism of Chinese hamster ovary (CHO) cell lines is typically characterized by high rates of aerobic glycolysis with increased lactate formation, known as the ”Warburg” effect.
Johannes Möller, Krathika Bhat, Lotta Guhl, Ralf Pörtner, Uwe Jandt, An‐Ping Zeng   +5 more
doaj   +1 more source

Genomic and Transcriptional Characteristics of Strain Rum-meliibacillus sp. TYF-LIM-RU47 with an Aptitude of Directly Producing Acetoin from Lignocellulose

Fermentation, 2022
Rummeliibacillus sp. TYF-LIM-RU47, isolated from the fermentation substrate of grain vinegar, could produce acetoin using a variety of carbon sources, including pentose, hexose and lignocellulose.
Guoyang Feng, Xiaojun Fan, Yanna Liang, Chen Li, Junde Xing, Yongji He   +5 more
doaj   +1 more source

Allosteric Regulation Alters Carrier Domain Translocation in Pyruvate Carboxylase [PDF]

, 2018
Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate. The reaction occurs in two separate catalytic domains, coupled by the long-range translocation of a biotinylated carrier domain (BCCP). Here, we use a series
Budelier, Melissa M., Liu, Yumeng, St. Maurice, Martin, Stine, Katelyn   +3 more
core   +3 more sources