Results 81 to 90 of about 114,163 (257)

Covalently bound substrate at the regulatory site triggers allosteric enzyme activation [PDF]

, 2008
The mechanism by which the enzyme pyruvate decarboxylase from yeast is activated allosterically has been elucidated. A total of seven three-dimensional structures of the enzyme, of enzyme variants or of enzyme complexes form two yeast species (three of ...
Georg Wille, Manfred Weiss, Michael Spinka, Ralph Golbik, Steffen Kutter, Stephan Kö   +5 more
core   +1 more source

Incomplete Wood-Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi. [PDF]

, 2014
The acetyl-CoA "Wood-Ljungdahl" pathway couples the folate-mediated one-carbon (C1) metabolism to either CO2 reduction or acetate oxidation via acetyl-CoA.
Alvarez-Cohen, Lisa, Bill, Markus, Brisson, Vanessa L, Conrad, Mark E, Feng, Xueyang, Men, Yujie, Tang, Yinjie J, Yi, Shan, Zhuang, Wei-Qin   +8 more
core   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Structure and functional characterization of pyruvate decarboxylase from Gluconacetobacter diazotrophicus [PDF]

, 2014
BACKGROUND: Bacterial pyruvate decarboxylases (PDC) are rare. Their role in ethanol production and in bacterially mediated ethanologenic processes has, however, ensured a continued and growing interest.
A Bjork, A Vagin, AA Kotze, AD Arencibia, AG Leslie, AK Chang, AT Baykal, B Chouaia, B Peters, CY Huang, D Dobritzsch, D Gocke, D Kern, D Meyer, D Meyer, D Rother, DKY Poon, Don A Cowan, E Potterton, E Zuckerkandl, EK James, G Lu, G Lu, G Schenk, G Vriend, GN Murshudov, GS Brandt, H Holzer, J Felsenstein, J Sambrook, JM Candy, K Lee, K Talley, K Tamura, KC Raj, KC Raj, LA Talarico, LA Talarico, Leonardo J van Zyl, LJ Van Zyl, LMS Lery, LMS Lery, LMS Lery, M Bertalan, M Couturier, M Mithran, M Pohl, M Tadege, MA Lie, Marla I Tuffin, MF dos Santosa, N Saitou, NS Nemeria, P Arjunan, P Emsley, P Evans, P Siegert, PM Kelley, PM Quigley, RA Frank, RA George, RS Bongers, RS Gokhale, RS Gold, S Bringer-Meyer, S Chakraborty, S Gomez-Manzo, S Kӧnig, S Lee, S Liu, S Liu, S Zhang, SE Lowe, SJ Kaczowka, TE King, U Menzel, UK Laemmli, VM Reis, VS Saravanan, WF Kellett, Wolf-Dieter Schubert, XY Pei, Z Dong, Z Vuralhan   +83 more
core   +2 more sources

PIK‐III‐Mediated Elevation of Thiamine Re‐Sensitises Renal Cell Carcinoma to Cuproptosis via Activating PDHA1

Cell Proliferation, EarlyView.
PIK‐III enhancing the efficacy of cuproptosis to kill renal cancer cells through dysregulating thiamine metabolism and dephosphorylation of pyruvate dehydrogenase complex E1 (PDHA1), providing a potential option for treatment of cuproptosis‐resistant renal cancer by the combination of PIK‐III and elesclomol.
Dongdong Xie, Yu Wang, Wenjie Cheng, Minbo Yan, Kunyu Li, Xiang Wu, Jiaqing Wu, Zhuangzhuang Zhang, Yingbo Dai   +8 more
wiley   +1 more source

Model-guided metabolic rewiring to bypass pyruvate oxidation for pyruvate derivative synthesis by minimizing carbon loss

mSystems
Engineering microbial hosts to synthesize pyruvate derivatives depends on blocking pyruvate oxidation, thereby causing severe growth defects in aerobic glucose-based bioprocesses.
Yun Zhang, Xueliang Wang, Christianah Odesanmi, Qitiao Hu, Dandan Li, Yuan Tang, Zhe Liu, Jie Mi, Shuwen Liu, Tingyi Wen   +9 more
doaj   +1 more source

Optimization of carbon and nitrogen utilization for enhanced photosynthesis, biomass and yield by coexpression of phosphoenolpyruvate carboxylase, aspartate aminotransferase and glutamine synthetase in Brassica juncea

Plant Biotechnology Journal, EarlyView.
Summary Coexpression of genes involved in carbon (C) and nitrogen (N) metabolism offers a promising avenue for improving crop yield. This study investigated the impact of coexpressing phosphoenolpyruvate carboxylase [ZmPEPC (P)], aspartate aminotransferase [GmAspAT (A)] and glutamine synthetase [NtGS (G)] in Brassica juncea to enhance plant yield ...
Mamta, Shiv Shanker Pandey, Anish Kaachra, Sachin Vashisath, Dinesh Kumar, Sanjay Kumar   +5 more
wiley   +1 more source

Chronic Inhibition of Mitochondrial Dihydrolipoamide Dehydrogenase (DLDH) as an Approach to Managing Diabetic Oxidative Stress

Antioxidants, 2019
Mitochondrial dihydrolipoamide dehydrogenase (DLDH) is a redox enzyme involved in decarboxylation of pyruvate to form acetyl-CoA during the cascade of glucose metabolism and mitochondrial adenine triphosphate (ATP) production.
Xiaojuan Yang, Jing Song, Liang-Jun Yan
doaj   +1 more source

Coexistence of Wolbachia with Buchnera aphidicola and a secondary symbiont in the aphid Cinara cedri.

, 2004
Intracellular symbiosis is very common in the insect world. For the aphid Cinara cedri, we have identified by electron microscopy three symbiotic bacteria that can be characterized by their different sizes, morphologies, and electrodensities.
García-Verdugo, José Manuel, Gómez-Valero, Laura, Heddi, Abdelaziz, Latorre, Amparo, Moya, Andrés, Pérez-Brocal, Vicente, Soriano-Navarro, Mario   +6 more
core   +2 more sources

Expanded roles of pyruvate-sensing PdhR in transcription regulation of the Escherichia coli K-12 genome: fatty acid catabolism and cell motility

Microbial Genomics, 2020
The transcription factor PdhR has been recognized as the master regulator of the pyruvate catabolism pathway in Escherichia coli , including both NAD-linked oxidative decarboxylation of pyruvate to acetyl-CoA by PDHc (pyruvate dehydrogenase complex) and ...
Takumi Anzai, S. Imamura, A. Ishihama, T. Shimada   +3 more
semanticscholar   +1 more source