Results 131 to 140 of about 4,126 (159)

Endurance training and pyruvate dehydrogenase kinase 4 (PDK4) inhibition combination is superior to each one alone in attenuating hyperketonemia/ketoacidosis in diabetic rats

Iranian Journal of Basic Medical Sciences
Objective(s): While ketone bodies are not the main heart fuel, exercise may increase their uptake. Objectives: This study aimed to investigate the effect of 6-week endurance training and Pyruvate dehydrogenase kinase 4 )PDK4( inhibition on ketone bodies ...
H. Rezaeinasab, A. Habibi, Ramin Rezaei, Aref Basereh, Salva Reverentia Yurista, Kayvan Khoramipour   +5 more
semanticscholar   +1 more source

Pyruvate Dehydrogenase-Dependent Metabolic Programming Affects the Oligodendrocyte Maturation and Remyelination

Molecular Neurobiology, 2023
M. Sajad, Insha Zahoor, Faraz Rashid, M. Cerghet, R. Rattan, S. Giri   +5 more
semanticscholar   +1 more source

Abstract 5151: Transcriptional regulation of the pyruvate dehydrogenase kinase Pdk2 by tumor suppressors

, 2012
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Conversion of pyruvate into lactate despite the presence of oxygen is a hallmark of the Warburg effect, and distinguishes the metabolism of many tumors from the metabolism of ...
Tanupriya Contractor, C. Harris
semanticscholar   +1 more source

Abstract 997: Oncogenic tyrosine kinases are localized to mitochondria and regulate cancer metabolism by phosphorylating key components of pyruvate dehydrogenase kinase complex

, 2012
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL The Warburg effect describes the observation that cancer cells take up more glucose than normal tissue and favor aerobic glycolysis.
J. Chen, T. Hitosugi, Jun Fan, Sumin Kang, T. Gu, T. Boggon   +5 more
semanticscholar   +1 more source

Trends in kinase drug discovery: targets, indications and inhibitor design

Nature Reviews Drug Discovery, 2021
Helgi B Schiöth, Misty M Attwood, Stefan Knapp   +2 more
exaly  

Kinase drug discovery 20 years after imatinib: progress and future directions

Nature Reviews Drug Discovery, 2021
Darren Cross, Pasi A Jänne, Philip Cohen   +2 more
exaly  

Kinase inhibition in autoimmunity and inflammation

Nature Reviews Drug Discovery, 2021
Ali A Zarrin, Bruno Hochhegger, Katherine Bao   +2 more
exaly  

Regulation of pyruvate dehydrogenase kinase and phosphatase by acetyl-CoA/CoA and NADH/NAD ratios.

Biochemical and Biophysical Research Communications - BBRC, 1975
F. Pettit, J. Pelley, L. Reed
semanticscholar   +1 more source

Evidence for lipoic acid mediated NADH and acetyl-CoA stimulation of liver and kidney pyruvate dehydrogenase kinase.

Biochemical and Biophysical Research Communications - BBRC, 1976
T. Roche, R. L. Cate
semanticscholar   +1 more source

Treatment of renal cell carcinoma: Current status and future directions

Ca-A Cancer Journal for Clinicians, 2017
Pedro Barata, Brian I Rini
exaly