Results 91 to 100 of about 131,923 (336)

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Unmasking the Warburg Effect: Unleashing the Power of Enzyme Inhibitors for Cancer Therapy

Drugs and Drug Candidates, 2023
The Warburg effect (or aerobic glycolysis), which was first described in 1926 by Otto Heinrich Warburg, consists of the change in glucose metabolism in cancer cells.
Eduardo Angulo-Elizari, Leire Gaviria-Soteras, Irati Zubiri, Sandra Ramos-Inza, Carmen Sanmartin, Daniel Plano   +5 more
doaj   +1 more source

Cardiosphere-derived cells demonstrate metabolic flexibility that Is influenced by adhesion status [PDF]

, 2017
Adult stem cells demonstrate metabolic flexibility that is regulated by cell adhesion status. The authors demonstrate that adherent cells primarily utilize glycolysis, whereas suspended cells rely on oxidative phosphorylation for their ATP needs.
Abraham, M. Roselle, Afzal, Junaid, Aon, Miguel A, Chan, Angel, Foster, D. Brian, Guan, Yufan, Karakas, Mehmet Fatih, O\u27Rourke, Brian, Pomper, Martin, Rathmell, Jeffrey, Tsui, Benjamin, Vakrou, Styliani, Wahl, Richard, Woldemichael, Kirubel   +13 more
core   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts

Pharmaceuticals
Rarely has a chemical elicited as much controversy as dichloroacetate (DCA). DCA was initially considered a dangerous toxic industrial waste product, then a potential treatment for lactic acidosis. However, the main controversies started in 2008 when DCA
Tomas Koltai, Larry Fliegel
doaj   +1 more source

Molecular mechanisms of glucose metabolism disorders in tumors of the female reproductive system

Акушерство, гинекология и репродукция, 2020
Glucose metabolism plays a pivotal role in fueling the energetic and biosynthetic demands in rapidly proliferating cells. In gynecologic malignancies (GMs), including ovarian cancer (OC), endometrial cancer (EC), and cervical cancer (CC), metabolic ...
E. Yu. Kovaleva, R. R. Kantimirova, T. K. Gunina, E. V. Vlasenko, D. O. Salychin, D. S. Khulagova, A. Kochkin, V. A. Mamatkova, N. S. Zhakov, G. K. Bezmaternykh, E. Yu. Fomenko, A. A. Mullagalieva, F. S. Ali, R. N. Imanova   +13 more
doaj   +1 more source

Quantitative constraint-based computational model of tumor-to-stroma coupling via lactate shuttle

, 2015
Cancer cells utilize large amounts of ATP to sustain growth, relying primarily on non-oxidative, fermentative pathways for its production. In many types of cancers this leads, even in the presence of oxygen, to the secretion of carbon equivalents ...
Capuani, Fabrizio, De Martino, Andrea, De Martino, Daniele, Marinari, Enzo   +3 more
core   +1 more source

Explicit consideration of topological and parameter uncertainty gives new insights into a well-established model of glycolysis [PDF]

, 2013
Previous models of glycolysis in the sleeping sickness parasite Trypanosoma brucei assumed that the core part of glycolysis in this unicellular parasite is tightly compartimentalized within an organelle, the glycosome, which had previously been shown to ...
Achcar, Albert, Bakker, Bakker, Bakker, Bakker, Blattner, Chevalier, Clarkson, Clarkson, Cronín, Fairlamb, Fairlamb, Gualdron-López, Gualdrón-López, Guerra-Giraldez, Haanstra, Haanstra, Hammond, Helfert, Häusler, Michels, Miškovíc, Murabito, Opperdoes, Rizk, Satish Kumar, Steiger, Tran, Visser, Wang   +30 more
core   +1 more source