Results 11 to 20 of about 2,082 (136)

Ketogenic Nutrition in Combination With PPARα Activation Induced Metabolic Failure and Exacerbated Muscle Weakness in Septic Mice. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Background Suppression of the peroxisome proliferator‐activated receptor alpha (PPARα) has been related to poor outcomes in sepsis and may compromise ketogenesis during critical illness. Infusion of 3‐hydroxybutyrate (3HB) was shown to attenuate muscle weakness in septic mice.
Lauwers C, Vankrunkelsven W, Derde S, Vander Perre S, Derese I, Pauwels L, Vanhorebeek I, Libbrecht L, Vermeersch P, Gunst J, Van den Berghe G, Casaer MP, Langouche L.   +12 more
europepmc   +2 more sources

Diversity of ThDP-Dependent Enzymes Forming Chiral Tertiary Alcohols. [PDF]

Chembiochem
Chiral tertiary alcohols are widespread in nature and bioactive compounds; however, their asymmetric synthesis faces several challenges. This review outlines the toolbox of ThDP‐dependent enzymes able to produce tertiary alcohols through the formation of CC bond formation using ketones as acceptor substrates. Herein, the substrate scope, the diversity
Bjarnesen D, Lanza L, Presini F, Giovannini PP, Müller M.   +4 more
europepmc   +2 more sources

Dihydrolipoamide dehydrogenase deficiency in five siblings with variable phenotypes, including fulminant fatal liver failure despite good engraftment of transplanted liver. [PDF]

JIMD Rep
Abstract Dihydrolipoamide dehydrogenase (DLD) deficiency can, in one of its forms, be a rare cause of acute liver failure. Clinical presentation is nonspecific. Biochemical findings can reflect metabolic block, but vary depending on patient and his condition. Consensus treatment guidelines do not exist.
Mihaljević M, Petković Ramadža D, Žigman T, Rako I, Galić S, Matić T, Rubić F, Čulo Čagalj I, Mayer D, Gojević A, Ćavar S, Ćorić M, Achleitner MT, Mayr JA, Fumić K, Vuković J, Barić I.   +16 more
europepmc   +2 more sources

Metabolic Reprogramming in Stromal and Immune Cells in Rheumatoid Arthritis and Osteoarthritis: Therapeutic Possibilities. [PDF]

Eur J Immunol
Immune cells and stromal cells undergo metabolic reprogramming in both rheumatoid and osteoarthritis. This review summarises current evidence on the metabolic changes within and the crosstalk between immune and stromal cells in these diseases. In addition, we explore the therapeutic potential of targeting metabolic processes for the treatment of ...
Henry ÓC, O'Neill LAJ.
europepmc   +2 more sources

Advances of SIRT4 in cancer metabolism and therapy

Pediatric Discovery, Volume 1, Issue 2, September 2023., 2023
Abstract The Sirtuins family consists of SIRT1‐SIRT7, which belong to class III of the histone deacetylases, a family of highly conserved NAD (nicotinamide adenine dinucleotide)‐dependent enzymes expressed in the nucleus, cytoplasm, and mitochondria.
Xiaohan Yue, Yulu Shi, Qing Luo
wiley   +1 more source

Effects of Soil Properties on Pb, Cd, and Cu Contents in Tobacco Leaves of Longyan, China, and Their Prediction Models

International Journal of Analytical Chemistry, Volume 2023, Issue 1, 2023., 2023
Longyan City in Fujian Province is one of China’s top‐quality tobacco‐producing areas and plays an essential role in local economic development. To determine the correlation between heavy metal content in tobacco leaves and soil factors, soil physical and chemical properties and heavy metal contents of lead, cadmium, and copper in tobacco leaves were ...
Wei Xi, YuanYe Ping, HaiYang Cai, Qian Tan, Chaoyang Liu, Junru Shen, YaWen Zhang, Danilo Corradini   +7 more
wiley   +1 more source

Characterization and epitope mapping of human monoclonal antibodies to PDC-E2, the immunodominant autoantigen of primary biliary cirrhosis [PDF]

, 1992
Further to define the epitopes of PDC-E2, the major autoantigen in primary biliary cirrhosis (PBC), we have developed and characterized five human monoclonal antibodies. These antibodies were derived by fusing a regional hepatic lymph node from a patient
Bassendine, Baum, Casali, Chambers, Coppel, Coppel, Cram, Flannery, Fregeau, Fregeau, Fujikura, Fusey, Fussey, Gershwin, Gershwin, Griffin, Griffin, James, Kaplan, Kunicki, Larrick, Leung, Leung, Mackay, Mackay, Mathews, McNeilage, Okamoto, Pollack, Ramsden, Reeves, Reimer, Robbins, Rokeach, Rowley, Ruther, Salemuddin, Sturgess, Sudin, Surh, Surh, Surh, Surh, Tan, Uibo, Van de Water, Van de Water, Van de Water, Van de Water, Williams   +49 more
core   +1 more source

Improvement of glycine biosynthesis from one‐carbon compounds and ammonia catalyzed by the glycine cleavage system in vitro

Engineering in Life Sciences, Volume 22, Issue 1, Page 40-53, January 2022., 2022
Abstract Glycine cleavage system (GCS) plays a central role in one‐carbon (C1) metabolism and receives increasing interest as a core part of the recently proposed reductive glycine pathway (rGlyP) for assimilation of CO2 and formate. Despite decades of research, GCS has not yet been well understood and kinetic data are barely available.
Yingying Xu, Jie Ren, Wei Wang, An‐Ping Zeng   +3 more
wiley   +1 more source

Modulation of SIRT1-Foxo1 Signaling axis by Resveratrol: Implications in Skeletal Muscle Aging and Insulin Resistance

Cellular Physiology and Biochemistry, 2015
Aging individuals and diabetic patients often exhibit concomitant reductions of skeletal muscle mass/strength and insulin sensitivity, suggesting an intimate link between muscle aging and insulin resistance.
Thomas K. Sin, Benjamin Y. Yung, Parco M. Siu   +2 more
doaj   +1 more source

Membrane electrochemical reactors (MER) for NADH regeneration in HLADH-catalysed synthesis: comparison of effectiveness [PDF]

, 2004
Two membrane electrochemical reactors(MER) were designed and applied to HLADH-catalysed reduction of cyclohexanone to cyclohexanol. The regeneration of the cofactor NADH was ensured electrochemically, using either methyl viologen or a rhodium complex as
Basséguy, Régine, Bergel, Alain, Délécouls-Servat, Karine   +2 more
core   +3 more sources