Results 31 to 40 of about 2,082 (136)

Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species [PDF]

, 2004
Mitochondria-produced reactive oxygen species (ROS) are thought to contribute to cell death caused by a multitude of pathological conditions. The molecular sites of mitochondrial ROS production are not well established but are generally thought to be ...
Beal, M. Flint, Browne, SE., Chinopoulos, Christos, Fiskum, G., Lorenzo, BJ., Patel, Mulchand S., Starkov, Anatoly A.   +6 more
core   +1 more source

Development of a cell-based target engagement assay for pyruvate dehydrogenase kinase

SLAS Discovery
Pyruvate dehydrogenase kinases (PDHKs) are non-canonical serine/threonine kinases that regulate the pyruvate dehydrogenase complex. Given their central role in metabolism, dysregulation of PDHKs has been linked with a broad variety of pathological ...
Mya D. Gough, Matthew B. Robers, Cesear R. Corona, Ranjit K. Mehta, Mukesh K. Nyati, Peter L. Toogood   +5 more
doaj   +1 more source

Muscle PGC-1α is required for long-term systemic and local adaptations to a ketogenic diet in mice [PDF]

, 2017
Low-carbohydrate/high-fat (LCHF) diets are increasingly popular dietary interventions for body weight control and as treatment for different pathological conditions.
Cardel, Bettina, Handschin, Christoph, Schnyder, Svenia, Svensson, Kristoffer   +3 more
core   +1 more source

Comparative proteomics analysis of root and nodule mitochondria of soybean

Plant, Cell &Environment, EarlyView.
Abstract Legumes perform symbiotic nitrogen fixation through rhizobial bacteroids housed in specialised root nodules. The biochemical process is energy‐intensive and consumes a huge carbon source to generate sufficient reducing power. To maintain the symbiosis, malate is supplied by legume nodules to bacteroids as their major carbon and energy source ...
Wai‐Ching Sin, Jinhong Liu, Jia Yi Zhong, Hon‐Ming Lam, Boon Leong Lim   +4 more
wiley   +1 more source

Perfil proteômico hipocampal em epilepsia do lobo temporal [PDF]

, 2012
In this study we used proteomics approaches to obtain the protein profile of human epileptic hippocampi (N=6) and control hippocampi obtained from autopsy (N=6).
Amorim, Rebeca Padrão [UNIFESP], Canzian, Mauro, Carrete Junior, Henrique [UNIFESP], Cavalheiro, Esper Abrão [UNIFESP], Centeno, Ricardo Silva [UNIFESP], De Lima-Stein, Mariana Leão [UNIFESP], Fernandes, Maria Jose da Silva [UNIFESP], Persike, Daniele Suzete [UNIFESP], Schenkman, Sergio [UNIFESP], Yacubian, Elza Márcia Targas [UNIFESP]   +9 more
core   +1 more source

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, Volume 13, Issue 7, 3 February 2026.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source

Structure of the cubic core and the lipoamide dehydrogenase component of the pyruvate dehydrogenase complex. [PDF]

, 1992
In this thesis, the crystal structures of the E3 component and of the catalytic domain of E2p are presented. These are the first atomic structures of the cubic core and of the E3 component of the pyruvate dehydrogenase and related multienzyme complexes ...
Mattevi, Andrea
core   +9 more sources

Homeostasis of metabolites in Escherichia coli on transition from anaerobic to aerobic conditions and the transient secretion of pyruvate [PDF]

, 2016
We have developed a method for rapid quenching of samples taken from chemostat cultures of Escherichia coli that gives reproducible and reliable measurements of extracellular and intracellular metabolites by 1H NMR and have applied it to study the ...
Beznosov SN, Churchward G, Evans CGT, Loferer-Krossbacher M, Nakata HM, Neidhart FC, O'Brien RW, Postma PW, Ruby EG, Takahashi N, Williamson MP   +10 more
core   +2 more sources

Biological Conversion of Formate to Organic Compounds: Toward a Sustainable Formate Bioeconomy

Carbon Energy, Volume 8, Issue 1, January 2026.
Formate bioconversion plays a crucial role in achieving renewable resource utilization and sustainable development. To tap its full potential, it is important to identify the most appropriate microbial hosts for incorporating formate into building blocks, design the most promising metabolic pathways for transmitting formate into central carbon ...
Jinyi Qian, Tiantian Chai, Chunlei Zhao, Xiulai Chen   +3 more
wiley   +1 more source

Absence of Complex I Is Associated with Diminished Respiratory Chain Function in European Mistletoe [PDF]

, 2018
Parasitism is a life history strategy found across all domains of life whereby nutrition is obtained from a host. It is often associated with reductive evolution of the genome, including loss of genes from the organellar genomes [1, 2].
Balk, Janneke, Bock, Ralph, Hertle, Alexander P, Ligas, Joanna, Maclean, Andrew E, Meyer, Etienne H   +5 more
core   +2 more sources