Results 41 to 50 of about 2,082 (136)

Which way does the citric acid cycle turn during hypoxia? The critical role of alpha-ketoglutarate dehydrogenase complex [PDF]

, 2013
The citric acid cycle forms a major metabolic hub and as such it is involved in many disease states involving energetic imbalance. In spite of the fact that it is being branded as a "cycle", during hypoxia, when the electron transport chain does not ...
Chinopoulos Christos
core   +1 more source

Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome

Clinical and Translational Medicine, Volume 15, Issue 5, May 2025.
EVs were isolated from plasma of ME/CFS patients and healthy controls at baseline, and 15 min and 24 h postexercise. Untargeted proteomics revealed dysregulation in energy metabolism, the complement system, and the endoplasmic reticulum stress response. Changes in EV protein levels postexercise are associated with post‐exertional malaise.
Katherine A. Glass, Ludovic Giloteaux, Sheng Zhang, Maureen R. Hanson   +3 more
wiley   +1 more source

Sulforaphane, a cancer chemopreventive agent, induces pathways associated with membrane biosynthesis in response to tissue damage by aflatoxin B1 [PDF]

, 2014
Aflatoxin B[subscript 1] (AFB[subscript 1]) is one of the major risk factors for liver cancer globally. A recent study showed that sulforaphane (SF), a potent inducer of phase II enzymes that occurs naturally in widely consumed vegetables, effectively ...
Croy, Robert G, Essigmann, John M, Fiala, Jeanette LouiseAllen, Groopman, John D., Navasumrit, Panida, Ruchirawat, Mathuros, Techapiesancharoenkij, Nirachara, Wogan, Gerald N   +7 more
core   +1 more source

Modulation of OPC Mitochondrial Function by Inhibiting USP30 Promotes Their Differentiation

Glia, Volume 73, Issue 4, Page 773-787, April 2025.
Main Points Mitochondrial changes occur during OPC differentiation and myelination. USP30 knockout promotes OPC differentiation and myelination in vitro. USP30 knockout OPCs and OLs exhibit differences in metabolism. ABSTRACT Multiple lines of evidence indicate that mitochondrial dysfunction occurs in demyelinating diseases, such as multiple sclerosis (
Allison L. Soung, Roxanne V. Kyauk, Shristi Pandey, Yun‐An A. Shen, Mike Reichelt, Han Lin, Zhiyu Jiang, Praveen Kirshnamoorthy, Oded Foreman, Benjamin E. Lauffer, Tracy J. Yuen   +10 more
wiley   +1 more source

The natural history of dihydrolipoamide dehydrogenase deficiency in Israel

Journal of Inherited Metabolic Disease, Volume 47, Issue 5, Page 895-902, September 2024.
Abstract Dihydrolipoamide dehydrogenase (DLD) deficiency is an ultra‐rare autosomal‐recessive inborn error of metabolism, affecting no less than five mitochondrial multienzyme complexes. With approximately 30 patients reported to date, DLD deficiency was associated with three major clinical presentations: an early‐onset encephalopathic phenotype with ...
Ben Pode‐Shakked, Yuval E. Landau, Nava Shaul Lotan, Joshua Manor, Nitsan Haham, Eyal Kristal, Eli Hershkovitz, Guy Hazan, Yarden Haham, Shlomo Almashanu, Yair Anikster, Orna Staretz‐Chacham   +11 more
wiley   +1 more source

Effects of negative energy balance on liver gene and protein expression during the early postpartum period and its impacts on dairy cow fertility [PDF]

, 2007
End of project reportNegative energy balance (NEB) is a severe metabolic affecting high yielding dairy cows early post partum with both concurrent and latent negative effects on cow fertility as well as on milk production and cow health.
Diskin, Michael G., Fenwick, M., Fitzpatrick, Richard, Kenny, David A., McCarthy, Sean D., Morris, Dermot G., Murphy, J.J., Patton, Joe, Waters, Sinead M., Wathes, D.C.   +9 more
core  

Development of novel EST-SSR markers in common carp by data mining from public EST sequences [PDF]

, 2007
Expressed sequence tags (ESTs) are a source for microsatellite development. In the present study, EST-derived microsatelltes (EST-SSRs) were generated and characterized in the common carp (Cyprinus carpio) by data mining from updated public EST databases
Cheng, Lei, Liao, Xiaolin, Tong, JG, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China, Tong, Jingou, Wang, Dan, Yu, Xiaomu   +5 more
core   +1 more source

Proteomic analysis of the effects of thioctic acid within meglumine thioctate

Фармакокинетика и Фармакодинамика, 2017
Proteomic analysis indicated 6 target proteins of thioctic acid (TA) and 11 proteins of TA metabolism, all of which are mitochondrial proteins.
I. I. Torshin, O. A. Gromova, O. I. Koifman, L. A. Maiorova   +3 more
doaj  

Reconstruction of an in silico metabolic model of _Arabidopsis thaliana_ through database integration [PDF]

, 2009
The number of genome-scale metabolic models has been rising quickly in recent years, and the scope of their utilization encompasses a broad range of applications from metabolic engineering to biological discovery.
Albert Gevorgyan, Jean-Marc Schwartz, Karin Radrich, Neil Swainston, Paul Dobson, Yoshimasa Tsuruoka   +5 more
core   +1 more source

Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle [PDF]

, 2015
Funding: This work was supported by CIBERobn (CB06/03/1008), Ministerio de Economía y Competitividad (MINECO) (PG: BFU2012-33334), Instituto de Salud Carlos III (ISCIII), MINECO, co-funded by UE-ERDF program (JS: CP12/03109), Red de Trastornos Adictivos (
Arrabal, Sergio, Baixeras, Elena, Canduela, Miren Josune, De Roos, Baukje, Decara, Juan, Fernández-Llébrez, Pedro, Grandes, Pedro, Lucena, Miguel Angel, Martín-Rufián, Mercedes, Márquez, Javier, Pavón, Francisco Javier, Ramos-Uriarte, Almudena, Rivera, Patricia, Rodríguez de Fonseca, Fernando, Serrano, Antonia, Suárez, Juan, Vargas, Antonio   +16 more
core   +4 more sources