Results 51 to 60 of about 2,082 (136)

Recent Progress in the Synthesis of α‐Hydroxy Carbonyl Compounds with ThDP‐dependent Carboligases

ChemCatChem, Volume 16, Issue 15, August 12, 2024.
Building carbon connections: ThDP‐dependent carboligases are biocatalysts for the (asymmetric) synthesis of α‐hydroxy‐carbonyl compounds. In this review article we summarize recent progress on structural characterization and application of carboligases for single‐ and multi‐step reactions.
Hana Dobiašová, Valentina Jurkaš, Peter Both, Margit Winkler   +3 more
wiley   +1 more source

Thioredoxins o1 and h2 jointly adjust mitochondrial dihydrolipoamide dehydrogenase‐dependent pathways towards changing environments

Plant, Cell &Environment, Volume 47, Issue 7, Page 2540-2558, July 2024.
Abstract Thioredoxins (TRXs) are central to redox regulation, modulating enzyme activities to adapt metabolism to environmental changes. Previous research emphasized mitochondrial and microsomal TRX o1 and h2 influence on mitochondrial metabolism, including photorespiration and the tricarboxylic acid (TCA) cycle.
Stefan Timm, Nicole Klaas, Janice Niemann, Kathrin Jahnke, Saleh Alseekh, Youjun Zhang, Paulo V. L. Souza, Liang‐Yu Hou, Maike Cosse, Jennifer Selinski, Peter Geigenberger, Danilo M. Daloso, Alisdair R. Fernie, Martin Hagemann   +13 more
wiley   +1 more source

Optimized submerged batch fermentation strategy for systems scale studies of metabolic switching in Streptomyces coelicolor A3(2) [PDF]

, 2012
Background: Systems biology approaches to study metabolic switching in Streptomyces coelicolor A3(2) depend on cultivation conditions ensuring high reproducibility and distinct phases of culture growth and secondary metabolite production.
Alexander Wentzel, Anders Øverby, David A Hodgson, Håvard Sletta, Per Bruheim, Trond E Ellingsen, Walid A M Omara, Øyvind M Jakobsen   +7 more
core   +3 more sources

Inactivation of Pseudomonas putida KT2440 pyruvate dehydrogenase relieves catabolite repression and improves the usefulness of this strain for degrading aromatic compounds

Microbial Biotechnology, Volume 17, Issue 6, June 2024.
Inactivation of pyruvate dehydrogenase in Pseudomonas putida relieved carbon catabolite repression, which inhibits the assimilation of non‐preferred compounds when other preferred carbon sources are present. The PDH‐null P. putida strain metabolized aromatic compounds in the presence of other preferred substrates, which the wild‐type strain does ...
Renata Moreno, Luis Yuste, Gracia Morales, Fernando Rojo   +3 more
wiley   +1 more source

Metabolic Bypass Rescues Aberrant S‐nitrosylation‐Induced TCA Cycle Inhibition and Synapse Loss in Alzheimer's Disease Human Neurons

Advanced Science, Volume 11, Issue 12, March 27, 2024.
Using human induced pluripotent stem cell (hiPSC)‐derived neurons and postmortem human Alzheimer's disease (AD) brains, the current study links aberrant S‐nitrosylation of tricarboxylic acid (TCA) cycle enzymes to a block in the TCA cycle, compromising energy production.
Alexander Y. Andreyev, Hongmei Yang, Paschalis‐Thomas Doulias, Nima Dolatabadi, Xu Zhang, Melissa Luevanos, Mayra Blanco, Christine Baal, Ivan Putra, Tomohiro Nakamura, Harry Ischiropoulos, Steven R. Tannenbaum, Stuart A. Lipton   +12 more
wiley   +1 more source

Poplar woody root proteome during the transition dormancy-active growth [PDF]

, 2013
Woody plants living in temperate climates finely regulate their growth and development in relation to seasonal changes; their transition from vegetative to dormancy phase represents an adaptation to their environment. Events occurring in the shoot during
Chiatante, D., Di Iorio, A., Montagnoli, A., Renzone, G., Rocco, M., Scaloni, A., Scippa, G.S., Terzaghi, M., Trupiano, D.   +8 more
core   +1 more source

Insight into the Stereoselective Synthesis of (1S)‐Nor(pseudo)ephedrine Analogues by a Two‐Steps Biocatalytic Process

ChemCatChem, Volume 16, Issue 3, February 8, 2024.
The stereodivergent synthesis of variously substituted norephedrines has been attained starting from the cheap and commercially available corresponding aromatic aldehydes through a bi‐enzymatic synthetic sequence. In the first step, a benzoin‐type condensation is mediated by the (S)‐selective acetoin:dichlorophenolindophenol oxidoreductase (Ao:DCPIP OR)
Noemi Fracchiolla, Stefania Patti, Fabio Sangalli, Daniela Monti, Francesco Presini, Pier Paolo Giovannini, Fabio Parmeggiani, Elisabetta Brenna, Davide Tessaro, Erica Elisa Ferrandi   +9 more
wiley   +1 more source

Clinical and biochemical characterization of four patients with mutations in ECHS1 [PDF]

, 2015
Short-chain enoyl-CoA hydratase (SCEH, encoded by ECHS1) catalyzes hydration of 2-trans-enoyl-CoAs to 3(S)-hydroxy-acyl-CoAs. SCEH has a broad substrate specificity and is believed to play an important role in mitochondrial fatty acid oxidation and in ...
Alberto Burlina, Curtis R. Coughlin, Frédéric M. Vaz, Hans R. Waterham, Jirair K. Bedoyan, Johan L. K. Van Hove, Jos P. N. Ruiter, Kaitlyn Bloom, Katherine Gowan, Kathryn Chatfield, Marisa W. Friederich, Megan K. Dishop, Michael J. Bennett, Orly Elpeleg, Renata C. Gallagher, Ronald J. A. Wanders, Sacha Ferdinandusse   +16 more
core   +1 more source

The Warburg effect in mycobacterial granulomas is dependent on the recruitment and activation of macrophages by interferon-γ [PDF]

, 2015
Granulomas are the hallmark of mycobacterial disease. Here, we demonstrate that both the cell recruitment and the increased glucose consumption in granulomatous infiltrates during Mycobacterium avium infection are highly dependent on interferon-y (IFN-y).
Abrunhosa, Antero J., Appelberg, Rui, Borges, Margarida, Dinis-Oliveira, Ricardo Jorge, Ferreira, Nuno C., Jordan, Michael B., Moreira, Diana, Neves, Margarida Correia, Resende, Mariana, Silva, Letícia, Silva, Palmira Conceição Araújo Barreira, Silvestre, Ricardo Jorge Leal   +11 more
core   +1 more source

The autoepitope of the 74-kD mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase. [PDF]

, 1988
Autoantibodies to mitochondrial antigens are characteristic of the autoimmune liver disease primary biliary cirrhosis (PBC), but the precise antigenic determinants recognized by these antibodies have not been defined.
Ansari, A, Coppel, R, Gershwin, M, Leung, P, Van De Water, Judith   +4 more
core