Activated Function of the Pyruvate Dehydrogenase Phosphatase through Ca2+-facilitated Binding to the Inner Lipoyl Domain of the Dihydrolipoyl Acetyltransferase* [PDF]
Journal of Biological Chemistry, 1996 Micromolar Ca2+ facilitates ∼10-fold enhancement of pyruvate dehydrogenase phosphatase (PDP) activity by aiding the association of PDP with the dihydrolipoyl acetyltransferase (E2) component. Connected by linker regions, E2 consists of two lipoyl domains,
Guilan Chen +4 more
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Cloning, Expression, and Properties of the Regulatory Subunit of Bovine Pyruvate Dehydrogenase Phosphatase* [PDF]
Journal of Biological Chemistry, 1997 cDNA encoding the regulatory subunit of bovine mitochondrial pyruvate dehydrogenase phosphatase (PDPr) has been cloned. Overlapping cDNA fragments were generated by the polymerase chain reaction from bovine genomic DNA and from cDNA synthesized from ...
J. E. Lawson +4 more
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Some properties of pea mitochondrial phospho-pyruvate dehydrogenase-phosphatase. [PDF]
Plant Physiology, 1987 Reactivation of the pea mitochondrial pyruvate dehydrogenase complex was the result of dephosphorylation catalyzed by phospho-pyruvate dehydrogenase-phosphatase, an intrinsic component of the complex.
J. Miernyk, D. Randall
semanticscholar +2 more sources
Role of the regulatory subunit of bovine pyruvate dehydrogenase phosphatase.
Proceedings of the National Academy of Sciences of the United States of America, 1996 Bovine pyruvate dehydrogenase phosphatase (PDP) is a Mg2+-dependent and Ca2+-stimulated heterodimer that is a member of the protein phosphatase 2C family and is localized to mitochondria.
J. Yan, J. E. Lawson, L. Reed
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Pyruvate Dehydrogenase Phosphatase Deficiency: A Cause of Congenital Chronic Lactic Acidosis in Infancy [PDF]
Pediatric Research, 1975 B. Robinson, W. Sherwood
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The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity [PDF]
Diabetes & Metabolism Journal, 2014 The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and ...
In-Kyu Lee
doaj +1 more source
Crystal structure of pyruvate dehydrogenase phosphatase 1 and its functional implications. [PDF]
Journal of Molecular Biology, 2007 D. Vassylyev, J. Symerský
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Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism [PDF]
Diabetes & Metabolism Journal, 2018 Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial pyruvate dehydrogenase complex
Sungmi Park +6 more
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Molecular Medicine, 2022 The mechanisms of chronic intermittent hypoxia (CIH)-induced cognitive deficits remain unclear. Here, our study found that about 3 months CIH treatment induced lipid droplets (LDs) accumulation in hippocampal nerve and glia cells of C57BL/6 mice, and ...
Dongze Li +11 more
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Antimicrobial Activity and Proposed Action Mechanism of Linalool Against Pseudomonas fluorescens
Frontiers in Microbiology, 2021 In this study, linalool, one of the principal components of essential oils, was used as an antibacterial agent to investigate the antibacterial activity and mechanism of linalool against Pseudomonas fluorescens.
Fengyu Guo +8 more
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