Results 201 to 210 of about 38,784 (240)
Some of the next articles are maybe not open access.
Pyruvate kinase electrophoresis in normal and pyruvate kinase deficient hemolysates
Clinica Chimica Acta, 1974Abstract Two bands of pyruvate kinase activity were demonstrated in normal hemolysates with high voltage electrophoresis at pH 5.3 using cellulose acetate strips. Heterozygotes with red cell pyruvate kinase deficiency also exhibited two bands. Six of ten homozygous patients showed two bands, the remaining four only one band.
B, Wonneberger, W, Schröter
openaire +2 more sources
2021
Pyruvate kinase is an important enzyme of glycolytic pathway that catalyzes the last step of this pathway. In human erythrocytes, there is no mitochondrion hence glycolytic pathway is the most important source of energy generation. In vitro, in vivo, and case control studies suggested that pyruvate kinase deficiency provides resistance against P ...
openaire +1 more source
Pyruvate kinase is an important enzyme of glycolytic pathway that catalyzes the last step of this pathway. In human erythrocytes, there is no mitochondrion hence glycolytic pathway is the most important source of energy generation. In vitro, in vivo, and case control studies suggested that pyruvate kinase deficiency provides resistance against P ...
openaire +1 more source
European Journal of Haematology, 2020 AbstractIntroductionCurrently recommended patient‐reported outcome (PRO) measures for patients with pyruvate kinase (PK) deficiency are non‐disease‐specific. The PK Deficiency Diary (PKDD) and PK Deficiency Impact Assessment (PKDIA) were developed to be more targeted measures for capturing the symptoms and impacts of interest to this patient population.
Rachael Grace, , Robert Klaassen
exaly +3 more sources
Erythrocyte Pyruvate Kinase Deficiency
Enzyme and Protein, 2017The dependence of the erythrocyte pyruvate kinase (PK)-catalyzed reaction on the glycolytic intermediates glucose-6-phosphate (Gluc-6-P), 2,3-diphosphoglycerate (2,3- DPG) and the nucleotides ADP and ATP was studied in normal individuals and 14 patients with PK deficiency.
Max Lakomek +6 more
openaire +2 more sources
On the molecular basis of pyruvate kinase deficiency
Biochimica et Biophysica Acta (BBA) - Enzymology, 1974Abstract Oxidized glutathione was found to be in the normal range in pyruvate kinase (ATP: pyruvate 2-O- phosphotransferase , EC 2.7.1.40) deficient erythrocytes and in erythrocytes from obligate heterozygotes with this inborn error of metabolism.
K G, Blume +3 more
openaire +2 more sources
Pyruvate Kinase Deficiency Complicating Pregnancy
Obstetrics & Gynecology, 2007Pyruvate kinase deficiency is the second-most common hereditary nonspherocytic hemolytic anemia. Only four affected patients' pregnancies have been reported since 1980.A 22-year-old without prior splenectomy experienced severe hemolytic anemia, with hematocrit as low as 19.0%, requiring serial transfusions.
Joseph R, Wax +3 more
openaire +2 more sources
1978
Hereditary nonspherocytic hemolytic anemia is a relatively recently recognized entity. It was first discussed in detail by Dacie et al, in 1953,1 and by 1960 over 60 cases had been reported.2 Motulsky et al.3 noted increased 2,3-DPG levels in several patients with hereditary nonspherocytic hemolytic anemia.
openaire +1 more source
Hereditary nonspherocytic hemolytic anemia is a relatively recently recognized entity. It was first discussed in detail by Dacie et al, in 1953,1 and by 1960 over 60 cases had been reported.2 Motulsky et al.3 noted increased 2,3-DPG levels in several patients with hereditary nonspherocytic hemolytic anemia.
openaire +1 more source
Biochimica et Biophysica Acta (BBA) - Enzymology, 1974
Abstract 1. 1. Human erythrocyte pyruvate kinase (ATP:pyruvate phosphotransferase, EC 2.7.1.40) from the class of pyruvate kinase-deficient patients, characterized by an increased affinity towards phosphoenolpyruvate and a loss of cooperative interaction towards this substrate, shows less affinity for the allosteric inhibitor ATP, when compared ...
Th.J.C. Van Berkel +4 more
openaire +1 more source
Abstract 1. 1. Human erythrocyte pyruvate kinase (ATP:pyruvate phosphotransferase, EC 2.7.1.40) from the class of pyruvate kinase-deficient patients, characterized by an increased affinity towards phosphoenolpyruvate and a loss of cooperative interaction towards this substrate, shows less affinity for the allosteric inhibitor ATP, when compared ...
Th.J.C. Van Berkel +4 more
openaire +1 more source
[Diagnosis of pyruvate kinase deficiency].
Ugeskrift for laeger, 1995Two children with nonspherocytic anaemia and pyruvate kinase deficiency had their diagnosis delayed due to normal initial estimations of enzyme activity. Repeated analyses involving other glycolytic enzymes documented an increased glucose-6-phosphate dehydrogenase activity as a function of high reticulocyte counts.
W, van Solinge, F C, Nielsen
openaire +3 more sources
Acquired pyruvate kinase deficiency.
Annals of clinical and laboratory science, 1977Pyruvate kinase (PK) is an enzyme of critical importance in the glycolytic pathway of the red cells, deficiency of which, whether congenital or acquired, results in a hemolytic anemia. Measurement of the enzyme is now rapid and simple utilizing preprepared substrate and reagents.
E E, Morse, F, Jilani, J, Brassel
openaire +1 more source