Results 181 to 190 of about 95,354 (345)

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

Ethyl Pyruvate Injection Enhances the Ischaemic Zone Viability in Burn Wounds in Rats. [PDF]

Vet Med Sci
Babalhakam HK, Maleki M, Noorbakhsh MF, Safari Nikroo K, Hayati F.   +4 more
europepmc   +1 more source

Heterogeneous ¹ H and ¹³ C Parahydrogen-Induced Polarization of Acetate and Pyruvate Esters. [PDF]

Chemphyschem, 2021
Salnikov OG, Chukanov NV, Kovtunova LM, Bukhtiyarov VI, Kovtunov KV, Shchepin RV, Koptyug IV, Chekmenev EY.   +7 more
europepmc   +1 more source

The bioavailability of calcium in the form of pyruvate, carbonate, citrate–malate in healthy postmenopausal women [PDF]

core   +1 more source

Critical Role of IL1R2‐ENO1 Interaction in Inhibiting Glycolysis‐Mediated Pyroptosis for Protection Against Lethal Sepsis

Advanced Science, EarlyView.
The authors have discovered that intracellular interleukin 1 receptor 2 (IL1R2) negatively regulates pyroptosis and inflammation by inhibiting glycolysis in sepsis. Soluble IL1R2 is released from macrophages undergoing pyroptosis. IL1R2 acts as a novel negative regulator of glycolysis by interacting with enolase 1 (ENO1), thereby inhibiting gasdermin D
Chuyi Tan, Han Ma, Jespar Chen, Gaifeng Ma, Alok Jha, Sipin Tan, Yaxi Zhu, Meidong Liu, Ke Liu, Xianzhong Xiao, Monowar Aziz, Huan Chen, Ping Wang, Huali Zhang   +13 more
wiley   +1 more source

The development of the occurrence and metastasis of breast cancer by single-cell sequencing. [PDF]

Cancer Cell Int
Chen M, Feng M, Lei H, Dan Mo, Ren S, Yang D.   +5 more
europepmc   +1 more source

The effect of temperature on catalytic and regulatory functions of pyruvate kinases of the rainbow trout and the Antarctic fish Trematomus bernacchii [PDF]

, 1968
George N. Somero, Peter W. Hochachka
openalex   +1 more source

PFKFB2‐Driven Glycolysis Promotes Dendritic Cell Maturation and Exacerbates Acute Lung Injury

Advanced Science, EarlyView.
Paraquat (PQ) or lipopolysaccharide (LPS) exposure activates the HIF‐1α–PFKFB2 pathway, driving glycolysis in dendritic cells (DCs). This metabolic shift enhances DC maturation and immune activation, exacerbating acute lung injury (ALI). This study demonstrates that PFKFB2‐driven glycolytic reprogramming in DCs plays a critical role in the pathogenesis
Ding Yuan, Fang Yang, Linlin Hou, Yan Zhang, Xin Pang, Yuqi Du, Hongyi Yan, Huanzhou Zhu, Yue Cheng, Yue Wu, Pinpin Jiang, Mengnan Guo, Mengying Zhang, Jinjie Guo, Huihui Hao, Yong Jiang, Yi Li, Yanxia Gao   +17 more
wiley   +1 more source

Effect of Light Regime on <i>Candidatus</i> Puniceispirillum marinum IMCC1322 in Nutrient-Replete Conditions. [PDF]

J Microbiol Biotechnol
Oh HM, Lee JH, Choi A, Yang SH, Shin GH, Kang SG, Cho JC, Kim HJ, Kwon KK.   +8 more
europepmc   +1 more source

PYRUVATE METABOLISM OF NORMAL RABBIT BONE MARROW IN VITRO

, 1950
J. D. Evans, M Seip
openalex   +1 more source