Results 201 to 210 of about 23,768 (211)

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

open access: yesAdvanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang   +12 more
wiley   +1 more source

Disordered Glass Nanowire Substrates Produce in Vivo‐Like Astrocyte Morphology Revealed by Low‐Coherence Holotomography

open access: yesAdvanced Science, EarlyView.
Low‐coherence holotomography reveals that disordered nanowire substrates guide astrocyte morphology toward branched, in vivo–like star‐shaped morphology, emphasizing the role of biophysical cues in shaping neural cell behavior. The developed nanostructured platform offers a new route to study astrocytes for neurobiology studies. Abstract Astrocytes are
Pooja Anantha   +11 more
wiley   +1 more source

The RNF/NQR redox pumps: a versatile system for energy transduction in bacteria and archaea. [PDF]

open access: yesAppl Microbiol Biotechnol
Buckel W   +4 more
europepmc   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

open access: yesAdvanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei   +10 more
wiley   +1 more source

Differences in Glycoproteins and the Potential for Early Protection Using LAIV Based on Drift Variants of the A/H1N1pdm09 Influenza Virus. [PDF]

open access: yesVaccines (Basel)
Desheva Y   +10 more
europepmc   +1 more source

Prospecting technology and economic potential to produce bio-succinic acid: a review. [PDF]

open access: yesBiotechnol Rep (Amst)
Silva DAS   +6 more
europepmc   +1 more source

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