Results 221 to 230 of about 24,261 (292)

A Feedback Loop Between Fatty Acid Metabolism and Epigenetics in Clear Cell Renal Carcinoma

open access: yesAdvanced Science, EarlyView.
The current study has profiled the landscape of active enhancers in ccRCC and identified FABP5 as an oncogene. FABP5 is essential for the lipid droplet formation driven by HIFs and critical for H3K27ac and enhancer activity. The study has discovered the function of a feedback loop between epigenetics and lipid metabolism regulated by FABP5 in ccRCC ...
Zhou Ye   +21 more
wiley   +1 more source

A pH‐Sensitive Nanosized Covalent–Organic Polymer for Enhanced Tumor Photodynamic Immunotherapy by Hypoxia Relief and STAT3 Inhibition

open access: yesAdvanced Science, EarlyView.
The nanosized covalent organic polymer composed of photosensitizer porphyrin, pyruvate kinase inhibitor vitamin K3, and STAT3 inhibitor WP1066 is prepared for enhanced photodynamic immunotherapy by simultaneous hypoxia relief and STAT3 inhibition. Abstract Photodynamic therapy (PDT) is a promising cancer therapy modality by generating reactive oxygen ...
Lei Lei   +7 more
wiley   +1 more source

Trypstatin as a Novel TMPRSS2 Inhibitor with Broad‐Spectrum Efficacy against Corona and Influenza Viruses

open access: yesAdvanced Science, EarlyView.
Trypstatin, a 61‐amino acid Kunitz‐type protease inhibitor derived from human Bikunin, potently inhibits TMPRSS2 and related proteases. It blocks spike‐ and hemagglutinin‐mediated entry of multiple respiratory viruses in vitro reduces SARS‐CoV‐2 replication in human airway cultures, and lowers viral load and symptoms in infected hamsters, demonstrating
Jan Lawrenz   +24 more
wiley   +1 more source

Characterization and Reuse of Lithium‐ion Battery Cathode Material Recovered Through a Bacterial Process

open access: yesAdvanced Energy Materials, EarlyView.
A sustainable bacteria‐based lithium‐ion battery cathode recycling method is optimized using engineering biology. The resulting biomineralized manganese carbonate species is found to be easily converted into an electrode material, via simple calcination.
Virginia Echavarri‐Bravo   +4 more
wiley   +1 more source

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