Results 221 to 230 of about 24,980 (288)

Functional and Structural Analyses of Diverse G‐Quadruplex and Non‐G‐Quadruplex Structures Formed by Guanine‐Rich Nucleic Acids: A Study on the Insulin Aptamer

open access: yesSmall, EarlyView.
IGA3, a guanine‐rich insulin aptamer, adopts different structures depending on environmental conditions. Under low cation concentrations, IGA3 forms a non‐G‐quadruplex structure that interacts with insulin. This finding highlights that guanine‐rich nucleic acids, in structures other than G‐quadruplex, can also bind to proteins, revealing valuable ...
Naoya Iwano   +9 more
wiley   +1 more source

Self‐Driving Microscopes: AI Meets Super‐Resolution Microscopy

open access: yesSmall Methods, EarlyView.
This review examines the use of machine learning to automate super‐resolution optical microscopy, enabling the microscope to autonomously make decisions on what, when, and how to image. By eliminating the need for human intervention, this approach has the potential to enhance the versatility and accessibility of super‐resolution microscopy.
Edward N. Ward   +3 more
wiley   +1 more source

Modular Droplet‐Based Microfluidic Platform for Functional Phenotypic Screening of Natural Killer Cells

open access: yesSmall Methods, EarlyView.
A droplet‐based microfluidic platform is developed to identify and sort Natural Killer (NK) cells with serial killing capacity. By combining high‐throughput droplet generation, deep learning‐based cytotoxicity analysis, and real‐time functional sorting, this platform enables efficient selection of highly cytotoxic NK cells.
Florian Aubermann   +8 more
wiley   +1 more source

K8sidecar: A Modular Kubernetes Chain of Sidecar Proxies for Microservices and Serverless Architectures

open access: yesSoftware: Practice and Experience, EarlyView.
ABSTRACT Background Modern microservice architectures demand not only modularity, scalability, and maintainability but also adaptation to dynamic requirements. For applications deployed on Kubernetes, sidecar proxies have been used to separate the operational features (such as security, networking, or monitoring) from the application business logic by ...
Andoni Salcedo‐Navarro   +2 more
wiley   +1 more source

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