Results 271 to 280 of about 936,931 (309)

Estrone direct photolysis: By-product identification using LC-Q-TOF

Chemosphere, 2012
The identification of degradation products generated upon photolysis of estrone (E1), a natural estrogenic hormone, under simulated UV irradiation conditions was addressed by the use of LC-Q-TOF mass spectrometry. The structures of the main degradation products were elucidated, demonstrating how the use of model molecules 5,6,7,8-tetrahydro-2-naphtol ...
Souissi, Yasmine, Bourcier, Sophie, Bouchonnet, Stephane, Genty, Christophe, Sablier, Michel   +4 more
openaire   +3 more sources

Identification of related substances in letrozole using LC-Q-TOF/MS

Journal of Pharmaceutical and Biomedical Analysis
Letrozole, a nonsteroidal aromatase inhibitor of the triazole class, is widely used in breast cancer treatment. Its quality and stability directly influence therapeutic efficacy and safety. However, systematic characterization of its related substances (RSs) remains insufficiently documented.
Zhao-liang Hu, Wen-yu Zou, Peng-wei Hu, Ke-ran Chen, Jia-ying Liu, Jie Deng, Ju-cui Yang, Min Song, Yu-ting Lu, Tai-jun Hang   +9 more
openaire   +2 more sources

UHPLC-Q/TOF-MS-based Ecometabolomic Study of Nepenthaceae

2021
Nepenthes, also known as tropical pitcher plant, is found with the capability to tolerate temperature stress in their natural habitat. The understanding on the adaptation mechanisms acquired by the plant toward the temperature stress is, however, limited.
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Recent Advances in Metabolite Identification And Quantitative Bioanalysis By Lc–Q-Tof Ms

Bioanalysis, 2012
The need for rapid, sensitive and effective identification and quantitation of drugs and metabolites to accelerate drug discovery and development has given MS its central position in drug metabolism and pharmacokinetic research. This review attempts to orient the readers with respect to hybrid Q-TOF MS, which enables accurate mass measurement and ...
Cen, Xie, Dafang, Zhong, Kate, Yu, Xiaoyan, Chen   +3 more
openaire   +2 more sources

Metabolism profiling of nevadensin in vitro and in vivo by UHPLC-Q-TOF-MS/MS

Journal of Chromatography B, 2018
Nevadensin is major constituents of Lysionotus pauciflorus Maxim. (Chinese name: Shidiaolan), which has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive. In this paper, we investigated the metabolism of nevadensin in vitro and in vivo.
Caijuan Liang, Xia Zhang, Xinpeng Diao, Man Liao, Yupeng Sun, Lantong Zhang   +5 more
openaire   +2 more sources

Human metabolism of synthetic isoflavones by GC-q-TOF

2017
Methoxyisoflavone and ipriflavone may be of interest in sport doping because they can be used by athletes in the recovering period after the administration of anabolic steroids to increase the natural production of luteinizing hormone (LH) and consequently the biosynthesis of natural androgens [1].
IANNONE, MICHELE, Silvia Parenti, Daniel Jardines, Francesco Botrè, Xavier de la Torre   +4 more
openaire   +2 more sources

[Analysis of flavonoids in Rhododendron mariae by UPLC/ Q-TOF-MS].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009
To investigate the flavonoids in Rhododendron mariae.The constituents in R. mariae were determined by UPLC/Q-TOF-MS. The chromatographic separation was performed on a C18 column (2.1 mm x 50 mm, 1.7 microm) with a gradient elufion of methanol-water containing 0.1% formic acid. The mass specfrometer eqaipped with elecfrospay ionizafion source was usedas
Huiqiang, Huang, Yifan, Feng, Wen, Rui, Miaomiao, Jiang, Liang, Han   +4 more
openaire   +1 more source

[Identification of a new sildenafil analogue based on Q-TOF-MS].

Yao xue xue bao = Acta pharmaceutica Sinica, 2016
The drugs such as sildenafil adulterated in herbal products and dietary supplements may endanger human health. The number of the new modified derivatives is increasing recently. Based on Q-TOF-MS, a new sildenafil analogue was found. It was isolated and purified by preparative liquid chromatography.
Jian, Sun, Hong, Yu, Qing, Hu, Rui, Feng, Su, Zhang, Shen, Ji   +5 more
openaire   +1 more source

Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS) Analysis for the Identification of Pathogenic Microorganisms: A Review

Microorganisms, 2021
Meng Xiao, Jing-Wei Cheng, Menglan Zhou   +2 more
exaly  

[UPLC-Q-TOF-MS-based metabolomics study of celastrol].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2019
The mass spectrometry-based metabolomics method was used to systematically investigate the formation of celastrol metabolites,and the effect of celastrol on endogenous metabolites. The mice plasma,urine and feces samples were collected after oral administration of celastrol.
Ting, Zhang, Yi-Kun, Wang, Qi, Zhao, Xue-Rong, Xiao, Fei, Li   +4 more
openaire   +1 more source