Results 1 to 10 of about 23,407 (181)
A phage display selection of engrailed homeodomain mutants and the importance of residue Q50 [PDF]
Nucleic Acids Research, 2004 Mutants of engrailed homeodomain (HD) that retain DNA-binding activity were isolated using a phage display selection. This selection was used to enrich for active DNA-binding clones from a complex library consisting of over a billion members. A more focused library of mutant homeodomains consisting of all possible amino acid combinations at two DNA ...
Simon, Matthew D. +3 more
openaire +4 more sources
Cis-regulatory basis of sister cell type divergence in the vertebrate retina [PDF]
eLife, 2019 Multicellular organisms evolved via repeated functional divergence of transcriptionally related sister cell types, but the mechanisms underlying sister cell type divergence are not well understood.
Daniel P Murphy +4 more
doaj +4 more sources
Circulation Journal, 2013 Reperfusion of ischemic myocardium may contribute to substantial cardiac tissue damage, but the addition of iron chelators, zinc or zinc complexes has been shown to prevent heart from reperfusion injury. We investigated the possible beneficial effects of an iron-chelating and zinc-complexing agent, Q50, in rat models of ischemia/reperfusion (I/R ...
Korkmaz, Sevil +18 more
openaire +6 more sources
Development of a new cell isolation device FlowMagicTM. [PDF]
PLoS ONEIsolation of human peripheral blood mononuclear cells (PBMCs) from blood typically involves a density gradient medium during density centrifugation. The problem of increasing red blood cell (RBC) and granulocyte (GRA) contamination during PBMC isolation ...
Tomoyuki Yoshida +5 more
doaj +2 more sources
Mutant huntingtin exon 1 protein detected in mouse brain with neoepitope antibody: effects of CAG repeat expansion, MutS Homolog 3 silencing and aggregation. [PDF]
Brain CommunHTT1a was identified in human and mouse Huntington’s disease brain as the pathogenic exon 1 mRNA generated from aberrant splicing between exon 1 and 2 of HTT that contributes to aggregate formation and neuronal dysfunction.1 Detection of the huntingtin ...
Sapp E +15 more
europepmc +2 more sources
Analysis of Flood Hydrograph Metro Sub Watershed with Synthetic Unit Hydrograph Snyder and SCS (Soil Conservation Service) Methods [PDF]
E3S Web of Conferences, 2023 Metro Sub-watershed is in Malang City. Based on data from BPBD Malang City, flood disasters have continued to increase from 2016 - 2022. The purpose of this research is to analyse the synthetic unit hydrograph (SUH) which will be used as the basis for ...
Dewi Mega Septia Sarda +6 more
doaj +1 more source
External Habits Formation and the Environment
Naše Gospodarstvo, 2021 The present paper presents a standard overlapping generations model with external habits formation and environmental quality in the utility function. Our main objective is to study the impact of external habits on capital accumulation and environmental ...
Safi Fatma
doaj +1 more source
Business Research Quarterly, 2022 In this essay, we connect the United Nations’ Sustainable Development Goals (SDGs)—an extensive collection of society-level goals and targets aimed at addressing grand challenges and achieving global sustainability by 2030—to firm-level sustainability ...
Javier Delgado‐Ceballos +3 more
semanticscholar +1 more source
Parameter estimation and treatment optimization in a stochastic model for immunotherapy of cancer [PDF]
, 2020 Adoptive Cell Transfer therapy of cancer is currently in full development and mathematical modeling is playing a critical role in this area. We study a stochastic model developed by Baar et al.
Coquille, Loren +2 more
core +2 more sources
Going green in logistics: The case of small and medium-sized enterprises in Poland
Journal of Economics and Management, 2021 Aim/purpose – The aim of the paper is to identify the features of ‘green’ small and medium-sized enterprises operating in Poland.
Zowada Krzysztof
doaj +1 more source