Results 51 to 60 of about 882,373 (307)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Recovery of topologically robust merging bound states in the continuum in photonic structures with broken symmetry

Nanophotonics
Optical bound states in the continuum (BICs) provide a unique mechanism of light confinement that holds great potential for fundamental research and applications.
Bai Huayu, Shevchenko Andriy, Kolkowski Radoslaw   +2 more
doaj   +1 more source

The K-meson form factor and charge radius: linking low-energy data to future Jefferson Laboratory measurements

European Physical Journal C: Particles and Fields, 2017
Starting from a successful model of the $$\pi $$ π -meson electromagnetic form factor, we calculate a similar form factor, $$F_{K}(Q^{2})$$ F K ( Q 2 ) , of the charged K meson for a wide range of the momentum transfer squared, $$Q^{2}$$ Q 2 .
A. F. Krutov, S. V. Troitsky, V. E. Troitsky   +2 more
doaj   +1 more source

A factorization method forq-Racah polynomials [PDF]

Journal of Difference Equations and Applications, 2012
We develop a factorization method for q-Racah polynomials. It is inspired to the approach to q-Hahn polynomials based on the q-Johnson scheme but we do not use association scheme theory nor Gel'fand pairs, but only manipolation of q-difference operators.
openaire   +5 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Coupling mechanism of a loop‐type ground radiation antenna

ETRI Journal, 2019
The coupling mechanism of a loop‐type ground radiation antenna is investigated in this paper. We use the equivalent circuit model of the antenna and a full‐wave simulation to explain the coupling mechanism of the antenna.
Zeeshan Zahid, Hyeongdong Kim
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Gravitational complexity factor of anisotropic polytropes in coincident gauge $$f(\mathbb {Q})$$ f ( Q ) gravity

European Physical Journal C: Particles and Fields
This work presents a novel characterization of complexity for gravitationally bound astrophysical configurations arising from two factors: (i) inhomogeneity and (ii) anisotropy in the complex arrangement of stellar structures. For this purpose, we employ
Abeer M. Albalahi, Akbar Ali, M. Z. Bhatti   +2 more
doaj   +1 more source