Results 111 to 120 of about 74,894 (355)

PrEP at the site of action in cisgender and transgender women: A pharmacology study of blood and rectal CD4+ lymphocytes

British Journal of Clinical Pharmacology, EarlyView.
Background Female sex hormones used in feminizing hormone therapy (FHT) may influence activation and persistence of HIV pre‐exposure prophylaxis (PrEP) medications. The clinical relevance of this interaction remains unclear, particularly for transgender and cisgender women (TGW and CGW).
Elizabeth Hastie, Megha Srivasta, Edward R. Cachay, Leah Burke, Sara Gianella, Stephen Rawlings, Frank Z. Stanczyk, Craig Sykes, Angela D. M. Kashuba, Jill Blumenthal, Mackenzie L. Cottrell   +10 more
wiley   +1 more source

Cost-effectiveness analysis of robotic-arm assisted versus manual total knee arthroplasty in the UK

Bone & Joint Open
Aims: The aim of this study was to estimate the additional cost per quality-adjusted life-year (QALY) of robotic-assisted total knee arthroplasty (rTKA) compared to manually performed total knee arthroplasty (mTKA).
Gurdeep S. Sagoo, Nick D. Clement, Yaneth Gil-Rojas, Nawaraj Bhattarai, Steven Galloway, Jenny B. Baron, Karen Smith, David J. Weir, David J. Deehan   +8 more
doaj   +1 more source

Reduce, Reuse, Recycle: New uses for old QA resources [PDF]

, 2018
Jeff Mitchell, Sebastian Riedel
openalex   +1 more source

Estimating the returns to UK publicly funded cancer-related research in terms of the net value of improved health outcomes [PDF]

, 2014
© 2014 Glover et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and ...
Academy of Medical Sciences, Access Economics, Access Economics, Alexandra Pollitt, Association of Medical Research Charities, B Bine Kjøller, C Godfrey, Cancer Research UK, CJL Murray, Deloitte Access Economics, DN Lakdawalla, EC Sun, European Medical Research Councils, FR Litchenberg, Funding First, G Dawson, G Libby, HE Karim-Kos, Health Economics Research Group, Office of Health Economics, RAND Europe, Independent UK Panel on Breast Cancer Screening, J Grant, J Karnon, Jonathan Grant, K Canfell, KM Murphy, M Buxton, M Buxton, Martin Buxton, Matthew Glover, MF Drummond, National Institute for Health and Clinical Excellence, National Institute for Health and Clinical Excellence, National Institute for Health and Clinical Excellence, National Institute for Health and Clinical Excellence. Colorectal Cancer, P Kind, PD Pharoah, S Capewell, S Guthrie, S Hanney, S Mushkin, S Whyte, S Wooding, S Wooding, S Wooding, SC Johnston, Stephen Hanney, Susan Guthrie, Wellcome Trust, World Health Organisation   +48 more
core   +5 more sources

Nicotinamide Reverses the Warburg Effect in CHO Cell Culture

Biotechnology and Bioengineering, EarlyView.
Abstract The Warburg effect, the preferential conversion of glucose‐derived pyruvat to lactate despite available oxygen, is a key feature of Chinese hamster ovary (CHO) cell culture. Lactate accumulation in recombinant protein‐producing cell culture is an inefficient usage of glucose, as well as being deleterious to cells.
James Morrissey, Ayca Cankorur‐Cetinkaya, Luigi Grassi, Annie J. Harwood‐Stamper, Jonathan Welsh, Ryte Poskute, Kasia Kozakowska‐McDonnell, Cleo Kontoravdi   +7 more
wiley   +1 more source

Haemophilia A: pharmacoeconomic review of prophylaxis treatment versus on-demand [PDF]

, 2015
Objectives. Haemophilia A is a congenital disorder of coagulation that mainly affects males and causes a considerable use of resources, especially when hemophilic patients are treated with prophylaxis.
BOCCIA, Antonio, LA TORRE, Giuseppe, Ricciardi, Walter, UNIM, BRIGID ANDOUNIMYE, Veneziano, Maria Assunta   +4 more
core   +2 more sources

Stock Exchange ESG Disclosure Guidance and Corporate Carbon Mitigation: International Evidence

Business Strategy and the Environment, EarlyView.
ABSTRACT This study investigates the tangible impact of the adoption of environmental, social, and governance (ESG) disclosure guidance by stock exchanges on corporate carbon mitigation, focusing on six major frameworks: the Global Reporting Initiative (GRI), the Sustainability Accounting Standards Board (SASB), the Task Force on Climate Related ...
Jiamian Yan, Le Luo, Nuraddeen Nuhu
wiley   +1 more source

Оценка качества жизни, связанного со здоровьем

Качественная клиническая практика, 2018
Исследование качества жизни, связанного со здоровьем, является новой современной методологией здравоохранения, позволяющей оценить результаты лечения больных, дополняя традиционные методики.

doaj  

The Oregon Plan and QALYs

AMA Journal of Ethics, 2005
A controversial Oregon plan used quality-of-life assessments to provide fewer health care services to a larger pool of Medicaid patients. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
openaire   +2 more sources

Expression, Purification, and Microscopy‐Based Assays for Engineered Recombinant Tyrosinated, Detyrosinated, and Δ2 Human Tubulin

Cytoskeleton, EarlyView.
ABSTRACT Microtubules are noncovalent polymers assembled from α/β tubulin dimers. Their structure, dynamics and interaction with effectors are regulated through the expression of diverse tubulin isotypes and chemically diverse posttranslational modifications, also known as the “tubulin code.” Understanding the biophysical correlates between tubulin ...
Jiayi Chen, Agnieska Szyk, Antonina Roll‐Mecak   +2 more
wiley   +1 more source