Results 111 to 120 of about 462 (153)

Unexpected Promotion of Bone Regeneration by Inhibition of BMPR1A‐Mediated BMP Signalling

Cell Proliferation, EarlyView.
BMPR1A downregulation reduces ID1, releases TCF3 to activate GNG4‐PI3K‐AKT signalling, thereby promoting OPC proliferation and bone regeneration. ABSTRACT Bone morphogenetic protein (BMP) signalling plays a pivotal role in bone regeneration by regulating osteoprogenitor cell (OPC) function, and BMPs have been widely used in clinical treatment. However,
Zihao Zhou, Yun Zhai, Xiaochen Liu, Jiaojiao Shao, Jiani Zhou, Zhaoyang Li, Jiale He, Shuxian Lin, Qi Zhang   +8 more
wiley   +1 more source

Post‐Event Strategies for Workplace Violence Affecting Hospital Staff: A Scoping Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aims To map the evidence on post‐incident strategies for workplace violence in global hospital settings, define current literature gaps and provide direction for future research. Design Scoping review guided by Joanna Briggs Institute methodology.
Dana Sammut, Nutmeg Hallett, Liz Lees‐Deutsch   +2 more
wiley   +1 more source

Transcriptional adapter ADA2 regulates yield and end‐use quality through liquid–liquid phase separation in wheat

Journal of Integrative Plant Biology, EarlyView.
The transcriptional adapter ADA2 interacts with the histone acetyltransferase GCN5 to regulate starch and storage protein content in wheat grains through histone acetylation. ADA2 undergoes phase separation and is modulated by GCN5, affecting histone acetyltransferase activity and gene transcription.
Xiaobang Zhang, Ruijie Zhang, Yuhan Zhang, Tao Yang, Longfei Wu, Yuan Cao, Jun Xiao, Jigang Li, Xin Gao, Xinyou Cao, Jie Liu, Mingming Xin, Yuan Zong, Zhongfu Ni, Qixin Sun, Yingyin Yao   +15 more
wiley   +1 more source

FcMAPK4‐phosphorylated FcNOR activates FcERF5 to promote fig fruit softening through activation of FcPG12 expression

Journal of Integrative Plant Biology, EarlyView.
In Ficus carica fruit, the MAP kinase FcMAPK4 phosphorylates the NAC transcription factor FcNOR, which cooperates with ethylene response factor FcERF5 to activate the pectin degradation gene FcPG12, thereby promoting rapid softening of fig fruit. ABSTRACT Rapid softening of fig (Ficus carica L.) fruit during ripening leads to extremely short shelf life;
Yuan Wang, Zhiyi Fan, Yining Wang, Alexander Vainstein, Yuexuan Qiu, Yinan Sun, Huiqin Ma   +6 more
wiley   +1 more source

Enhancing CRISPR‐Cas12a base editing in plants with LbCas12a variants and introns

Journal of Integrative Plant Biology, EarlyView.
Intron optimization of LbCas12a‐RRV improves cytosine and adenine base editing efficiency in plants, supports multiplexed and double‐strand break‐free genome modification, and expands precise genome engineering tools for crop breeding and plant functional research. ABSTRACT Cytosine base editors (CBEs) and adenine base editors (ABEs) are powerful tools
Yanhao Cheng, Gen Li, Man Zhou, Rushil Mandlik, Doris Wang, Yiping Qi   +5 more
wiley   +1 more source

Factors That Influence the Implementation of Animal‐Assisted Intervention for People With Dementia in Community Care Settings: A Qualitative Study

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim To explore the factors that influence the implementation of animal‐assisted intervention (AAI) for people with dementia in community care settings in Ireland. Design Descriptive qualitative study. Methods Semi‐structured interviews were carried out with 13 people with dementia, 11 care partners and 18 health and social care practitioners ...
Dou Zhang, Marita Hennessy, Nuala Paley, Gerry Paley, Catherine Houghton   +4 more
wiley   +1 more source

Do robots boost productivity? A quantitative meta‐study

Journal of Economic Surveys, EarlyView.
ABSTRACT This meta‐study analyzes the productivity effects of industrial robots. More than 1800 estimates from 85 primary studies are collected. The meta‐analytic evidence suggests that robotization has so far provided, at best, a small boost to productivity. There is strong evidence of publication bias in the positive direction.
Florian Schneider
wiley   +1 more source

Effects of Electroacupuncture at ST36 on Visceral Pain and Inflammatory Markers in IBS Rats

Neurogastroenterology &Motility, EarlyView.
Electroacupuncture (EA) at ST36 significantly reduced visceral pain and colonic inflammation in IBS model rats. EA increased pain thresholds, lowered AWR scores, and downregulated key inflammatory mediators (IL‐1β, IL‐6, TNF‐α, TRPV1, NF‐κB). These findings highlight ST36‐targeted EA as a promising therapeutic strategy for IBS visceral hypersensitivity
Ya‐bo Hao, Yan‐lin Liu, Xiao‐mei Wang, Kai Cheng, Qing‐yu Tu, Fei Dai, Xi‐bing Yang   +6 more
wiley   +1 more source

The unicellular green microalga Botryosphaerella sudetica links plant‐like light protection with an algal lifestyle

New Phytologist, EarlyView.
Summary Nonphotochemical quenching (NPQ) mechanisms fine‐tune light utilisation in the photosynthetic antenna, for example, in response to excess light, to prevent photodamage. NPQ comprises distinct mechanisms, all contributing to photoprotection but acting on different time scales.
Olga Blifernez‐Klassen, Hanna Berger, Viktor Klassen, Swapnil Chaudhari, Thomas Baier, Lutz Wobbe, Olaf Kruse   +6 more
wiley   +1 more source

Ligand‐induced ubiquitination regulates endocytosis and homeostasis of the ERECTA receptor kinase for stomatal development

New Phytologist, EarlyView.
Summary Stomatal patterning on the plant epidermis is regulated by the ERECTA family of leucine‐rich repeat receptor kinases (LRR‐RKs). While ubiquitination has emerged as a key regulatory mechanism for the endocytosis of receptor kinases, the precise molecular connections among ERECTA ubiquitination, endocytosis, and its biological functions remain ...
Liangliang Chen, Minh Huy Vu, Pengfei Bai, Alicia M. Cochran, Crystal F. Ying, Keiko U. Torii   +5 more
wiley   +1 more source