Results 11 to 20 of about 109,660 (100)

KEYNOTE-991: pembrolizumab plus enzalutamide and androgen deprivation for metastatic hormone-sensitive prostate cancer.

open access: yesFuture Oncology, 2023
Current treatment for patients with metastatic hormone-sensitive prostate cancer (mHSPC) delays disease progression and improves survival, but resistance is inevitable. Additional therapies that prolong survival are needed.
C. Gratzke   +8 more
semanticscholar   +1 more source

Inhibition of basal and glucagon-induced hepatic glucose productionby 991 and other pharmacological AMPK activators.

open access: yesBiochemical Journal, 2022
Pharmacological AMPK activation represents an attractive approach for the treatment of type 2 diabetes (T2D). AMPK activation increases skeletal muscle glucose uptake, but there is controversy as to whether AMPK activation also inhibits hepatic glucose ...
M. Johanns   +13 more
semanticscholar   +1 more source

A new K+channel-independent mechanism is involved in the antioxidant effect of XE-991 in an in vitro model of glucose metabolism impairment: implications for Alzheimer’s disease

open access: yesCell Death Discovery, 2022
Alzheimer’s disease (AD) is a neurodegenerative disorder that represents the first cause of dementia. Although there has been significant progress in AD research, the actual mechanisms underlying this pathology remain largely unknown. There is increasing
S. Piccirillo   +6 more
semanticscholar   +1 more source

Sarcoma of the Breast: Clinical Characteristics and Outcomes of 991 Patients from the National Cancer Database

open access: yesSarcoma, 2021
Background Sarcoma of the breast is a rare malignancy with heterogeneous histology. Angiosarcoma, including secondary angiosarcoma from previous radiation, is the most common type of sarcoma of the breast.
J. S. Lee, K. Yoon, M. Onyshchenko
semanticscholar   +1 more source

DFNA5 (GSDME) c.991-15_991-13delTTC: Founder Mutation or Mutational Hotspot?

open access: yesInternational Journal of Molecular Sciences, 2020
Deafness due to mutations in the DFNA5 gene is caused by the aberrant splicing of exon 8, which results in a constitutively active truncated protein. In a large family of European descent (MORL-ADF1) segregating autosomal dominant nonsyndromic hearing ...
K. Booth, H. Azaiez, Richard J. H. Smith
semanticscholar   +1 more source

Effects of academic self-regulation on procrastination, academic stress and anxiety, resilience and academic performance in a sample of Spanish secondary school students

open access: yesFrontiers in Psychology, 2023
Introduction One of the biggest challenges facing students today is procrastination, which is closely related to stress, anxiety and, in the most severe cases, depression.
Antonio Ragusa   +7 more
semanticscholar   +1 more source

IMA–CNMNC approved mineral symbols

open access: yesMineralogical magazine, 2021
Several text symbol lists for common rock-forming minerals have been published over the last 40 years, but no internationally agreed standard has yet been established.
L. Warr
semanticscholar   +1 more source

Organophosphate Pesticides and Pyrethroids in Farmland of the Pearl River Delta, China: Regional Residue, Distributions and Risks

open access: yesInternational Journal of Environmental Research and Public Health, 2023
A regional-scale survey was conducted to assess the occurrence, distribution, and risk of two extensively used pesticides (organophosphate pesticides and pyrethroids) in agricultural soils from the Pearl River Delta (PRD), South China.
Runlin Yao   +5 more
semanticscholar   +1 more source

The earliest arbitration treaty? A reassessment of the Anglo-Norman treaty of 991*

open access: yes, 2020
Concluded at Rouen in March 991, the Anglo-Norman treaty has traditionally occupied a very small corner of the huge historiography for King AEthelred’s reign as one of the first of the king’s failures to deal with the threat of renewed viking raids. This
J. Benham
semanticscholar   +1 more source

Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle

open access: yesAmerican Journal of Physiology. Endocrinology and Metabolism, 2016
AMP-activated protein kinase (AMPK) plays diverse roles and coordinates complex metabolic pathways for maintenance of energy homeostasis. This could be explained by the fact that AMPK exists as multiple heterotrimer complexes comprising a catalytic α ...
L. Bultot   +14 more
semanticscholar   +1 more source

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