Results 141 to 150 of about 798,107 (304)

A Phase 1, Randomized, Placebo‐Controlled, Multiple‐Dose, Double‐Blind Study to Evaluate and Compare the Pharmacokinetics and Safety of Rimegepant in Healthy Adult Japanese and Caucasian Individuals

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This Phase 1, randomized, placebo‐controlled, double‐blind study assessed the pharmacokinetic profile of rimegepant (25, 75, or 150 mg once daily for 14 days) in healthy Japanese and Caucasian adults. Exposures were modestly increased in Japanese participants compared with Caucasian participants following a single dose of rimegepant (Day 1 ...
Rajinder Bhardwaj, Chay Ngee Lim, Yinhua Li, Kyle T. Matschke, Richard Bertz, Robert Croop, Jing Liu   +6 more
wiley   +1 more source

Effect of Inpatient Cardiac Rehabilitation on QT Dispersion in Patients with Acute Myocardial Infarction

Acta Medica Iranica, 2013
QT dispersion is an indicator of lack of ventricular repolarization homogeneity and an independent predictor for ventricular arrhythmia and sudden cardiac death.
Zahra Ansari, Sina Rafat, Mohammad Vahid Jorat, Mahdieh Ghanbari-Firoozabadi, Masoud Mirzaei, Mohammadtaghi Sarebanhassanabadi   +5 more
doaj  

Comparison of QT dispersion before and after PDA device closure in pediatrics. [PDF]

Ann Noninvasive Electrocardiol, 2022
Khalilian MR, Ziaratban M, Alizadeh P, Norouzi AR, Shirvani A.   +4 more
europepmc   +1 more source

Population Pharmacokinetic and Exposure‐Efficacy Analysis of Baloxavir Marboxil for Influenza Treatment and Post‐Exposure Prophylaxis in Children

Clinical Pharmacology &Therapeutics, EarlyView.
Baloxavir acid (baloxavir), the active metabolite of the prodrug baloxavir marboxil, is a selective inhibitor of the influenza virus cap‐dependent endonuclease. The population pharmacokinetic (popPK) profile of baloxavir in adults/adolescents has been described previously.
Sylvie Retout, Stefan De Buck, Jacques Gaudreault, Sébastien Jolivet, Vincent Duval, Valérie Cosson, Marie‐Laure Delporte   +6 more
wiley   +1 more source

Instabilities of localized structures in dissipative systems with delayed feedback

, 2012
We report on a novel behavior of solitary localized structures in a real Swift-Hohenberg equation subjected to a delayed feedback. We shall show that variation in the product of the delay time and the feedback strength leads to nontrivial instabilities ...
Friedrich, R., Gurevich, S. V.
core   +1 more source

Left ventricular mechanical dispersion by tissue Doppler imaging: a novel approach for identifying high-risk individuals with long QT syndrome [PDF]

, 2008
Kristina H. Haugaa, Thor Edvardsen, Trond P. Leren, Jon Michael Gran, Otto A. Smiseth, J. P. Amlie   +5 more
openalex   +1 more source

Corporate Social Responsibility and Financial Performance in Europe: The Moderating Effects of Industry, Culture, and Governance

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This paper investigates the relationship between corporate social responsibility (CSR) and financial performance for European firms, and the moderating roles of industry and country‐specific factors in this relationship. Studying a sample of 2340 companies across 18 countries, we find Environmental, Social and Governance (ESG) scores to ...
Veda Fatmy, Venla Haavisto, Janne Äijö
wiley   +1 more source

Evaluation of the relationship between the level of addiction and exhaled carbon monoxide levels with QT dispersion in smokers. [PDF]

Tob Induc Dis, 2021
Keskin G, Karaman ST, Basat O.
europepmc   +1 more source

Cardiorespiratory cross‐frequency coupling biomarker for sudden unexpected death in epilepsy

Epilepsia, EarlyView.
Abstract Objective Sudden unexpected death in epilepsy (SUDEP) often follows generalized tonic–clonic seizures during sleep, likely resulting from impaired brainstem cardiorespiratory function. We used ictal electrocardiogram (ECG)‐based cross‐frequency phase–amplitude coupling (PAC) to detect cardiorespiratory disruptions, comparing SUDEP to non‐SUDEP
Adam C. Gravitis, Richard Wennberg, Peter L. Carlen, Yotin Chinvarun, Victor Lira, Juliana Laze, Orrin Devinsky, Berj L. Bardakjian   +7 more
wiley   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source