Results 181 to 190 of about 516,463 (286)

Accelerating virtual patient generation with a Bayesian optimization and machine learning surrogate model

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.
Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley   +1 more source

Plant‐Derived Natural Product Nanodelivery System in Cancer Therapy

Phytotherapy Research, EarlyView.
This review comprehensively summarizes the recent progress and emerging concepts in nanotechnology‐based delivery systems for plant‐derived natural products, with a particular focus on their application in precision cancer therapy. ABSTRACT Plant‐derived natural products have emerged as important sources of anticancer agents because of their diverse ...
Changqi Shi, LuLu Zhang, Lan Yan, Qi Geng, Li Li, Xiaojuan He, Ning Zhao, Yong Tan, Xiaomeng Zhang, Cheng Lu   +9 more
wiley   +1 more source

Myocardial bridging is associated with exercise-induced ventricular arrhythmia and increases in QT dispersion. [PDF]

Ann Noninvasive Electrocardiol, 2018
Nishikii-Tachibana M, Pargaonkar VS, Schnittger I, Haddad F, Rogers IS, Tremmel JA, Wang PJ.   +6 more
europepmc   +1 more source

Mapping Scytonemin Pigment Content and Biocrust Functional Indicators Using High‐Resolution Multispectral Imagery

Remote Sensing in Ecology and Conservation, EarlyView.
We demonstrate that high‐resolution multispectral imagery combined with machine learning can accurately predict key biocrust functional indicators, particularly the UV‐protective pigment scytonemin, across dryland ecosystems. Using fine‐scale imagery acquired in the Chihuahuan Desert and Colorado Plateau, we identified spectral bands strongly ...
Raúl Román, Tong Qiu, Fernando T. Maestre, Elizabeth A. La Rue, Sergio Vargas Zesati, Anthony Schaefer, Ryan V. Trexler, Nicole Pietrasiak, Estelle Couradeau   +8 more
wiley   +1 more source

Efficient and Accurate Spatio‐Temporal Population Monitoring of Mobile Animals Using Drones and Computer Vision

Remote Sensing in Ecology and Conservation, EarlyView.
Drones and computer vision offer an efficient way to estimate animal populations over localized areas, but surveys often require stitching many overlapping images together. If animals move during the survey, traditional orthomosaic‐based counting methods become unreliable, with some animals appearing in multiple locations while others appear not at all,
Benjamin Koger, Albert B. Kao, Curry J. Cunningham, Thomas P. Quinn, Caroline Kittle, Andrew M. Berdahl   +5 more
wiley   +1 more source

Local labor market frictions and platform‐based entrepreneurship

Strategic Entrepreneurship Journal, EarlyView.
Abstract Research Summary Building on prior research about the heterogeneous impact of labor shocks on individuals' propensity to start businesses, we explore how local labor market frictions affect individuals' selection into platform‐based entrepreneurship.
Ruiqing Cao, Yifan Lyu
wiley   +1 more source

Solar‐Powered Water Depollution Through a Bioinspired Device Based on ZIF‐8 Loaded Macroporous Hydrogels Prepared via Ice‐Templating

Small, EarlyView.
ABSTRACT Water pollution poses a constant threat to the environment and is one of the central causes for global shortage of clean water. Metal–Organic Frameworks (MOFs) have emerged as highly efficient adsorbents; however, their application is limited by their common production as fine powders, which hinders recovery and reuse.
Katsuya Komiyama, Jonathan Bachir, Francisco M. Fernandes, Clémence Sicard   +3 more
wiley   +1 more source

Beyond Integer Charge Transfer: A New Design Rule Linking Dopant Strength and Counterion Separation to Efficient Carrier Transport in Conjugated Polymers

Small, EarlyView.
In this Research Article, the authors introduce a new design principle for doped conjugated polymers, showing that dopant energy depth relative to the host polymer (ΔE) can be leveraged to minimize Coulomb interactions and boost conductivity. This discovery offers a new and simple strategy to optimize the performance of organic electronics for everyday
Muhamed Duhandžić, Subhayan Samanta, Dhandapani Venkataraman, Zlatan Akšamija   +3 more
wiley   +1 more source

Bioelectronic Wearable Sensors Produced by Computerized Embroidery Using a Dual Thread Approach

Small, EarlyView.
A dual‐thread embroidered SmartBra integrates silver‐plated and conductive‐polymer (PECOTEX) threads to enable simultaneous cardiac monitoring and open‐circuit potentiometric sensing of potassium and sodium in a breast milk substitute. The wearable platform is fabricated using computerized embroidery, offering a scalable, proof‐of‐concept route toward ...
Taliya Weinstein, Xintong Li, Hasan Kurt, Selin Olenik, Alexander Silva‐Pinto Collins, José Manuel Rodrigueiro Flauzino, Muhammed Adeel, Laura Gonzalez‐Macia, Meral Yüce, Firat Güder   +9 more
wiley   +1 more source

Photoactivated iridium(III) complexes drive pyroptosis–necroptosis synergy for multi‐network photoimmunotherapy of renal cell carcinoma

Smart Molecules, EarlyView.
Photoactivated iridium(III) complexes trigger mitochondrial DNA leakage and Ca²⁺ efflux, simultaneously driving pyroptosis and necroptosis to synergistically enhance immunogenic cell death. This multi‐network cascade promotes dendritic cell maturation and CD8⁺ T cell activation, achieving potent photoimmunotherapy of renal cell carcinoma.
Xin Qin, Meng‐Di Chen, Wenqi Gao, Yiping Wang, Lin‐Qing Liu, Zhen Teng, Tienan Qi, Qiyuan Wang, Yuxuan Wang, Daoxiang Li, Keqiang Yan, Ling Pan, Zhongwei Zhao, Shuo Zhao, Kang‐Nan Wang, Shuai Fu, Nengwang Yu   +16 more
wiley   +1 more source