Results 211 to 220 of about 798,107 (304)

Measurement, interpretation and clinical potential of QT dispersion.

open access: yesJournal of the American College of Cardiology, 2000
M. Malik, V. Batchvarov
semanticscholar   +1 more source

Gene List Selection Matters: Missed Diagnoses in Prenatal Exome Sequencing—PanelApp R21 and HPO‐Driven Versus OMIM‐Based Gene Lists

open access: yesPrenatal Diagnosis, EarlyView.
ABSTRACT Objective To evaluate whether the causative variants found upon clinical exome sequencing in fetuses affected with selected structural anomalies would also be detected if PanelApp‐R21 or Human Phenotype Ontology (HPO)‐driven gene selection terms were applied instead.
Victoria Ardiles‐Ruesjas   +7 more
wiley   +1 more source

A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet   +8 more
wiley   +1 more source

Accelerating virtual patient generation with a Bayesian optimization and machine learning surrogate model

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.
Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley   +1 more source

Changes of QT Dispersion in Patients Suffering from Aluminium Phosphide Poisoning (Rice Pill). [PDF]

open access: yesOpen Access Maced J Med Sci, 2019
Eshraghi A   +4 more
europepmc   +1 more source

Prognostic Significance of QT Interval Dispersion in the Response to Intravenous Immunoglobulin Therapy in Kawasaki Disease

open access: diamond, 2017
Noriko Motoki   +6 more
openalex   +2 more sources

A Mini Review of Scientific Designs of Dynamic Responsive Fluids in Battery Technologies

open access: yesRare Metals, EarlyView.
ABSTRACT Dynamic responsive fluids are emerging as transformative elements in the evolution of battery technologies, marking a pivotal shift from static passive designs toward systems that actively sense and adapt to their operating environments. By integrating dynamic responsive fluids, batteries can interact with both internal and external stimuli in
Xiu‐Zhen Yang   +11 more
wiley   +1 more source

Local Search and the Evolution of World Models

open access: yesTopics in Cognitive Science, EarlyView., 2023
Abstract An open question regarding how people develop their models of the world is how new candidates are generated for consideration out of infinitely many possibilities. We discuss the role that evolutionary mechanisms play in this process. Specifically, we argue that when it comes to developing a global world model, innovation is necessarily ...
Neil R. Bramley   +3 more
wiley   +1 more source

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