Results 181 to 190 of about 73,159 (323)

Inhibitory effect of oestradiol on the cardiac KV7.1/KCNE1 channel is species dependent

Experimental Physiology, EarlyView.
Abstract Oestradiol (17β‐E2) is reported to prolong the cardiac action potential duration and QT interval, in part by affecting cardiac ion channels. Previous studies found inhibiting 17β‐E2 effects on the repolarizating cardiac KV7.1/KCNE1 channel, or its native current, in heterologous expression systems or tissue from animal species.
Veronika A. Linhart, Lucas Dauga, Sara I. Liin   +2 more
wiley   +1 more source

QT INTERVAL PROLONGATION IS A NOVEL PREDICTOR OF 1-YEAR MORTALITY IN PATIENTS WITH COVID-19 INFECTION [PDF]

J Am Coll Cardiol, 2022
Banai A, Szekely Y, Lupu L, Borohovitz A, Levi E, Ghantous E, Taieb P, Hochstadt A, Banai S, Topilsky Y, Chorin E.   +10 more
europepmc   +2 more sources

Salbutamol-Induced QT Interval Prolongation in a Two-Year-Old Patient. [PDF]

Cureus, 2022
Elgassim M, Abdelrahman A, Saied ASS, Ahmed AT, Osman M, Hussain M, AlJaufi I, Salem W.   +7 more
europepmc   +1 more source

Drug-Induced QT Prolongation: Individual Susceptibility and Regulatory Issues Related to Safety Pharmacology 5. QT Interval: Gender and Other Affecting Factors in the Clinical Setting

, 2006
Tetsunori Saikawa
openalex   +2 more sources

Computational study of the excitation of human induced pluripotent stem cell‐derived cardiomyocytes

Experimental Physiology, EarlyView.
Abstract Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs) have proven to be a revolutionary advance for tissue engineering, disease modelling, and drug testing and discovery. Computational modelling enables detailed electrophysiological analysis that is otherwise difficult or impossible to achieve under strictly experimental ...
Roshni Shetty, Raffi Samurkashian, Leslie Tung   +2 more
wiley   +1 more source

Evaluation of Ondansetron-induced QT interval prolongation in the prophylaxis of postoperative emesis

, 2011
Ranabir Pal, Aniruddha Sarkar, Sudakshina Mukherjee, Koel Mitra, Suddhadeb Roy, Debabrata Sarbapalli, KanakKanti Kundu, ForhadAkhtar Zaman, Sumit Kar, SampaDutta Gupta   +9 more
openalex   +1 more source

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker, Andrew F. James, Svetlana Mastitskaya   +2 more
wiley   +1 more source

Syncope with QT-interval prolongation and T-wave inversion in anterior and inferior leads: Foreboder of a life-threatening condition? [PDF]

Ann Noninvasive Electrocardiol, 2023
Li JX, Wang J, Li XQ, Gao M.
europepmc   +1 more source

Prospective in silico trials identify combined SK and K2P channel block as an effective strategy for atrial fibrillation cardioversion

The Journal of Physiology, EarlyView.
Abstract figure legend In silico trials were conducted in 654 virtual patients with atrial fibrillation (AF) to assess the cardioversion efficacy of three pharmacological treatments: single SK and K2P channel block and combined SK+K2P channel inhibition. Left: representative virtual AF patient with the atria inside the torso.
Albert Dasí, Lucas Arantes Berg, Hector Martinez‐Navarro, Alfonso Bueno‐Orovio, Blanca Rodriguez   +4 more
wiley   +1 more source

QT PRODACT: Sensitivity and Specificity of the Canine Telemetry Assay for Detecting Drug-Induced QT Interval Prolongation

, 2005
Hiroyasu Miyazaki, Hiroyuki Watanabe, Tetsuya Kitayama, Masahiro Nishida, Yasuhiro Nishi, Koji Sekiya, Hideki Suganami, Keiji Yamamoto   +7 more
openalex   +2 more sources