Results 191 to 200 of about 73,159 (323)

Kawasaki Disease Shock Syndrome With Progressive AV Block and Atrioventricular Dissociation: Case Report

Journal of Paediatrics and Child Health, EarlyView.
Chengjun Dai, Jiao Chen, Yutong Chen, Yingchao Ying, Yanlan Fang, Zihao Yang, Chunlin Wang   +6 more
wiley   +1 more source

In silico modelling of multi‐electrode arrays for enhancing cardiac drug testing on hiPSC‐CM heterogeneous tissues

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti, Rolf Krause, Luca F. Pavarino   +2 more
wiley   +1 more source

Mathematical model of the zebrafish ventricular cardiomyocyte action potential and calcium transient

The Journal of Physiology, EarlyView.
Abstract figure legend This study presents the development and validation of the first biophysically detailed computational model of the zebrafish ventricular action potential (AP). The model is based on a human cardiomyocyte framework and reparameterized using published and newly generated patch‐clamp recordings of zebrafish ionic currents.
Ludovica Cestariolo, Zachary D. Long, Arie O. Verkerk, Jose M. Ferrero, T. Alexander Quinn, Jose F. Rodriguez Matas   +5 more
wiley   +1 more source

QT Interval Prolongation with One or More QT-Prolonging Agents Used as Part of a Multidrug Regimen for Rifampicin-Resistant Tuberculosis Treatment: Findings from Two Pediatric Studies. [PDF]

Antimicrob Agents Chemother, 2023
Ali AM, Radtke KK, Hesseling AC, Winckler J, Schaaf HS, Draper HR, Solans BP, van der Laan L, Hughes J, Fourie B, Nielsen J, Garcia-Prats AJ, Savic RM.   +12 more
europepmc   +1 more source

Electrophysiological characterization of pre‐adolescents born with intrauterine growth restriction: insights from clinical and computational data

The Journal of Physiology, EarlyView.
Abstract figure legend Depolarization and repolarization duration analysis was conducted in preadolescent groups with IUGR and controls using a 12‐lead ECG. Principal component analysis was applied over the 12‐lead ECGs to generate spatially transformed leads better suited for robust ECG fiducial points detection.
Freddy L. Bueno‐Palomeque, Ernesto Zacur, Esther Pueyo, Fàtima Crispi, Pablo Laguna, Ana Mincholé   +5 more
wiley   +1 more source

Clinical-pharmacological aspects of the safe use of medicines, causing prolongation of QT interval

Безопасность и риск фармакотерапии, 2018
Specific aspects of manifestation of prolonged QT syndrome, developed during the use of drugs belonging to different pharmacological groups are discussed. It analyses data on dangerous combinations of drugs that prolong the QT interval.
O. A. Demidova, E. V. Shikh, A. D. Ismagilov, Zh. M. Sizova   +3 more
doaj  

Heart rate-corrected QT interval prolongation is associated with decreased heart rate variability in patients with type 2 diabetes. [PDF]

Medicine (Baltimore), 2022
Cha SA.
europepmc   +1 more source

Editorial: Safety Pharmacology – Risk Assessment QT Interval Prolongation and Beyond [PDF]

, 2018
Eleonora Grandi, Stefano Morotti, Esther Pueyo, Blanca Rodríguez   +3 more
openalex   +1 more source

The apicobasal dispersion of ventricular repolarization in humans is associated with age and affects arrhythmia vulnerability

The Journal of Physiology, EarlyView.
Abstract figure legend We investigated the age‐ and sex‐related differences in the apicobasal repolarization gradient (ABRG) and evaluated their possible role inventricular arrhythmia vulnerability. Electrocardiographic imaging (ECGI) was performed in healthy subjects during sinus rhythm, and the average recovery time (RT) and activation–recovery ...
Vladimír Sobota, Job Stoks, Kiran Haresh Kumar Patel, Roshni Shetty, Haibo Ni, Eleonora Grandi, Fu Siong Ng, Paul G. A. Volders, Matthijs J. M. Cluitmans, Jason D. Bayer   +9 more
wiley   +1 more source

QT interval prolongation: clinical assessment, risk factors and quantitative pharmacological considerations. [PDF]

J Pharmacokinet Pharmacodyn
Gotta V, Donner B.
europepmc   +1 more source