Results 261 to 270 of about 73,159 (323)

QT PRODACT: In Vivo QT Assay in the Conscious Dog for Assessing the Potential for QT Interval Prolongation by Human Pharmaceuticals

open access: bronze, 2005
Shigeki Toyoshima   +9 more
openalex   +2 more sources

Management of xylazine toxicity, overdose, dependence, and withdrawal: A systematic review

open access: yesThe American Journal on Addictions, Volume 34, Issue 6, Page 589-602, November 2025.
Abstract Background and Objectives Xylazine, an alpha‐2‐adrenergic agonist, has been increasingly implicated in substance use and overdose crises. However, little is known about its effects on humans. With the growing public health crisis surrounding xylazine, it has become important to recognize and promptly manage symptoms of xylazine toxicity ...
Philipa Owusu‐Antwi   +4 more
wiley   +1 more source

When the U Wave Tells the Story: Andersen–Tawil Syndrome Unmasked

open access: yesAnnals of Noninvasive Electrocardiology, Volume 30, Issue 6, November 2025.
Recurrent syncope in a young woman was diagnosed as Andersen‐Tawil syndrome (ATS), characterized by prominent U waves and prolonged QTU intervals. Genetic testing confirmed a KCNJ2 mutation. Tailored treatment, including medication adjustments, led to symptom improvement, emphasizing the importance of accurate diagnosis and management in ATS.
Shasha Yu, Hang Lv
wiley   +1 more source

Bumetanide Treatment in 15 Children With Autism: A Randomised Waitlist‐Control Study

open access: yesActa Paediatrica, Volume 114, Issue 11, Page 2985-2992, November 2025.
ABSTRACT Aim Bumetanide, a diuretic, influences neuronal chloride homeostasis and potentially restores GABAergic inhibition and neuronal signalling balance. This mechanism may contribute to improvements in autism‐related symptoms. The present study builds on the preclinical research and on previous clinical research on bumetanide treatment for children
Elisabeth Fernell   +7 more
wiley   +1 more source

Children and Young Adults Who Used Medication for Attention Deficit Hyperactivity Disorder Faced Increased Cardiac Risks

open access: yesActa Paediatrica, Volume 114, Issue 11, Page 3021-3033, November 2025.
ABSTRACT Aim There have been concerns about links between medication for attention deficit hyperactivity disorder (ADHD) and cardiac events in children and young people. Our aim was to identify any associations. Method This Swedish case–control study used national register data to identify individuals aged 5–30 years who received their first diagnosis ...
Howaida Elmowafi   +4 more
wiley   +1 more source

Twenty‐Four Hour Rhythms in Cardiovascular Physiology

open access: yesActa Physiologica, Volume 241, Issue 11, November 2025.
ABSTRACT Many physiological parameters, such as heart rate and blood pressure, display pronounced daily rhythms, with significant differences between day and night levels. The ability to anticipate the 24 h cycle of ambient light confers an adaptive advantage, allowing organisms to prepare for periods of activity and rest.
Morten B. Thomsen
wiley   +1 more source

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