Cholinesterase inhibitors-associated torsade de pointes/QT prolongation: a real-world pharmacovigilance study [PDF]
Frontiers in Pharmacology, 2023 Objective: Cholinesterase inhibitor (ChEIs) is the first-line drug for Alzheimer’s disease (AD). Understanding torsade de pointes (TdP)/QT prolongation with different ChEIs is essential for its safe and rational administration.
Ni Zhang +8 more
doaj +2 more sources
Assessing the Risk of QT Prolongation in a Psychiatric Inpatient Cohort: A Retrospective Cross-Sectional Study [PDF]
PharmaceuticalsBackground: QT prolongation is a potential serious adverse drug reaction, and assessing the risk of QT-prolonging drugs is routinely included in psychotropic medication reviews. However, the actual clinical benefits of such assessments are unknown.
Johan Frederik Mebus Meyer Christensen +5 more
doaj +2 more sources
Evaluation of rosuvastatin-induced QT prolongation risk using real-world data, in vitro cardiomyocyte studies, and mortality assessment [PDF]
Scientific Reports, 2023 Drug-induced QT prolongation is attributed to several mechanisms, including hERG channel blockage. However, the risks, mechanisms, and the effects of rosuvastatin-induced QT prolongation remain unclear.
Yeryung Koo +7 more
doaj +2 more sources
QT Prolongation due to Graves’ Disease [PDF]
Case Reports in Cardiology, 2017 Hyperthyroidism is a highly prevalent disease affecting over 4 million people in the US. The disease is associated with many cardiac complications including atrial fibrillation and also less commonly with ventricular tachycardia and fibrillation. Many cardiac pathologies have been extensively studied; however, the relationship between hyperthyroidism ...
Zain Kulairi +4 more
openalex +4 more sources
Detecting QT prolongation from a single-lead ECG with deep learning. [PDF]
PLOS Digital HealthFor a number of antiarrhythmics, drug loading requires a 3-day hospitalization with continuous monitoring for QT-prolongation. Automated QT monitoring with wearable ECG monitors would enable out-of-hospital care.
Ridwan Alam +2 more
doaj +2 more sources
Ondansetron-induced QT prolongation among various age groups: a systematic review and meta-analysis [PDF]
The Egyptian Heart Journal, 2023 Background Ondansetron is a selective 5-hydroxytryptamine type 3 serotonin-receptor antagonist with antiemetic properties used inadvertently in the emergency department for controlling nausea.
Kamaldeep Singh +16 more
doaj +2 more sources
Drug-induced QT prolongation and torsade de pointes: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System database [PDF]
Frontiers in Pharmacology, 2023 Introduction: Drug-induced QT prolongation and (or) Torsade de Pointes (TdP) is a well-known serious adverse reaction (ADR) for some drugs, but the widely recognized comprehensive landscape of culprit-drug of QT prolongation and TdP is currently lacking ...
Dongxuan Li +10 more
doaj +2 more sources
Assessing the risk of QT prolongation in primary care [PDF]
Ann Fam Med, 2023 Vishal Bhella, Divya Garg
europepmc +3 more sources
Evaluation of qt prolongation in patients following conduction system pacing implantation [PDF]
EuropaceMehrdad Golian +6 more
europepmc +3 more sources
A Polygenic Predictor of Baseline QTc is Associated With Sotalol-Induced QT Prolongation. [PDF]
CirculationLancaster MC +6 more
europepmc +3 more sources