Results 21 to 30 of about 143,558 (182)

Time for a Fully Integrated Nonclinical–Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective

Clinical pharmacology and therapy, 2020
Defining an appropriate and efficient assessment of drug‐induced corrected QT interval (QTc) prolongation (a surrogate marker of torsades de pointes arrhythmia) remains a concern of drug developers and regulators worldwide.
H. Vargas, M. Rolf, Todd A. Wisialowski, W. Achanzar, A. Bahinski, A. Bass, Charles T Benson, K. Chaudhary, N. Couvreur, C. Dota, M. Engwall, C. Michael Foley, D. Gallacher, A. Greiter-Wilke, J. Guillon, B. Guth, H. Himmel, C. Hegele‐Hartung, Maki Ito, S. Jenkinson, K. Chiba, A. Lagrutta, P. Levesque, E. Martel, Y. Okai, Ravikumar Peri, A. Pointon, Yusheng Qu, A. Teisman, M. Traebert, T. Yoshinaga, G. Gintant, D. Leishman, J. Valentin   +33 more
semanticscholar   +1 more source

QT prolongation in a diverse, urban population of COVID-19 patients treated with hydroxychloroquine, chloroquine, or azithromycin

Journal of interventional cardiac electrophysiology, 2020
Purpose Hydroxychloroquine, chloroquine, and azithromycin have been used for treatment of COVID-19, but may cause QT prolongation. Minority populations are disproportionately impacted by COVID-19.
Brian C Hsia, Nicolas Greige, J. Quiroz, Ahmed Khokhar, J. Daily, L. Di Biase, K. Ferrick, J. Fisher, A. Krumerman   +8 more
semanticscholar   +1 more source

Torsade de pointes in liver transplantation recipient after induction of general anesthesia: a case report [PDF]

Korean Journal of Anesthesiology, 2014
Torsade de pointes (TdP) is an uncommon and specific form of polymorphic ventricular tachycardia, associated with a prolonged QT interval. Prolongation of the QT interval is the most widely recognized electrophysiological abnormality in patients with ...
Eun-Jin Chung, Yun-Seok Jeon, Hyun-Joo Kim, Kook Hyun Lee, Ji-Won Lee, Kyoung-Ah Han, Seung-Hwan Jung   +6 more
doaj   +1 more source

QT prolongation in HIV-positive patients: Review articleKey points

Indian Heart Journal, 2019
Introduction: Antiretrovirals have immensely increased the average life expectancy of HIV-positive patients. However, the incidence of QT interval prolongation and other arrhythmias has also increased. Methods: Pubmed and Google Scholar were searched for
Jing Liu, Sumit K. Shah, Indranill Basu-Ray, Julia Garcia-Diaz, Kainat Khalid, Mohammad Saeed   +5 more
doaj   +1 more source

Pharmacometabolomic approach to predict QT prolongation in guinea pigs. [PDF]

PLoS ONE, 2013
Drug-induced torsades de pointes (TdP), a life-threatening arrhythmia associated with prolongation of the QT interval, has been a significant reason for withdrawal of several medicines from the market. Prolongation of the QT interval is considered as the
Jeonghyeon Park, Keumhan Noh, Hae Won Lee, Mi-sun Lim, Sook Jin Seong, Jeong Ju Seo, Eun-Jung Kim, Wonku Kang, Young-Ran Yoon   +8 more
doaj   +1 more source

Ventricular arrhythmia in patients with prolonged QT interval during liver transplantation: two cases report [PDF]

Korean Journal of Anesthesiology, 2014
QT interval prolongation is associated with an increased risk of ventricular arrhythmia in various conditions. Cardiac electrophysiologic abnormalities including QT interval prolongation are well documented in patients with advanced liver cirrhosis.
Min-Soo Kim, Na Young Kim, Ji Eun Park, Soon Ho Nam   +3 more
doaj   +1 more source

THE WAYS TO ENHANCE SAFETY OF COMBINATIONS OF DRUGS PROLONGING QT INTERVAL IN THE OUT-PATIENT AND POLYCLINIC PRACTICE

Вестник анестезиологии и реаниматологии, 2018
Prolongation of QT interval is a predictor of fatal disorders of cardiac rhythm and sudden death. Side effects of medications is one of the main causes of prolonged QT interval.
E. V. Shikh, Zh. M. Sizova, A. D. Ismagilov, M. A. Vyzhigina   +3 more
doaj   +1 more source

A current understanding of drug-induced QT prolongation and its implications for anticancer therapy.

Cardiovascular Research, 2019
The QT interval, a global index of ventricular repolarization, varies among individuals and is influenced by diverse physiologic and pathophysiologic stimuli such as gender, age, heart rate, electrolyte concentrations, concomitant cardiac disease, and ...
D. Roden
semanticscholar   +1 more source

Cancer treatment and drug-induced QT interval prolongation: A review

Consilium Medicum, 2022
Anticancer drugs can cause drug-induced prolongation of the QT interval. Prolongation of the QT interval is a known risk factor and an independent predictor of the development of life-threatening ventricular arrhythmias (polymorphic ventricular ...
Olga D. Ostroumova, Aleksey I. Kochetkov, Valeria A. De   +2 more
doaj   +1 more source

Risk Evaluation of Azithromycin-Induced QT Prolongation in Real-World Practice

BioMed Research International, 2018
Background Azithromycin exposure has been reported to increase the risk of QT prolongation and cardiovascular death. However, findings on the association between azithromycin and cardiovascular death are controversial, and azithromycin is still used in ...
Young Choi, H. Lim, Dahee Chung, Junggu Choi, D. Yoon   +4 more
semanticscholar   +1 more source