Towards understanding the clinical significance of QT peak prolongation: a novel marker of myocardial ischemia independently demonstrated in two prospective studies [PDF]
, 2015 Background: QT peak prolongation identified patients at risk of death or non-fatal MI. We tested the hypothesis that QT peak prolongation might be associated with significant myocardial ischaemia in two separate cohorts to see how widely applicable the ...
Ball, Jeff B +10 more
core +1 more source
Torsade de pointes in liver transplantation recipient after induction of general anesthesia: a case report [PDF]
Korean Journal of Anesthesiology, 2014 Torsade de pointes (TdP) is an uncommon and specific form of polymorphic ventricular tachycardia, associated with a prolonged QT interval. Prolongation of the QT interval is the most widely recognized electrophysiological abnormality in patients with ...
Eun-Jin Chung +6 more
doaj +1 more source
Pharmacogenetics of Drug-Induced QT Interval Prolongation: An Update [PDF]
, 2015 A prolonged QT interval is an important risk factor for ventricular arrhythmias and sudden cardiac death. QT prolongation can be caused by drugs. There are multiple risk factors for drug-induced QT prolongation, including genetic variation.
Berg, M.E. (Marten) van den +4 more
core +1 more source
QT peak prolongation predicts cardiac death following stroke [PDF]
, 2015 Cardiac death has been linked in many populations to prolongation of the QT interval (QTe). However, basic science research suggested that the best estimate of the time point when repolarisation begins is near the T-wave peak.
Douglas, Denise +7 more
core +1 more source
Trigger versus Substrate: Multi-Dimensional Modulation of QT-Prolongation Associated Arrhythmic Dynamics by a hERG Channel Activator [PDF]
, 2017 Background: Prolongation of the QT interval of the electrocardiogram (ECG), underlain by prolongation of the action potential duration (APD) at the cellular level, is linked to increased vulnerability to cardiac arrhythmia.
Antzelevitch +57 more
core +2 more sources
A Common Genetic Variant Risk Score is Associated with Drug-Induced QT Prolongation and Torsade de Pointes Risk: A Pilot Study. [PDF]
, 2017 Background -Drug-induced QT interval prolongation, a risk factor for life-threatening ventricular arrhythmias, is a potential side effect of many marketed and withdrawn medications.
Behr, ER +11 more
core +2 more sources
QT prolongation in HIV-positive patients: Review articleKey points
Indian Heart Journal, 2019 Introduction: Antiretrovirals have immensely increased the average life expectancy of HIV-positive patients. However, the incidence of QT interval prolongation and other arrhythmias has also increased. Methods: Pubmed and Google Scholar were searched for
Jing Liu +5 more
doaj +1 more source
Ventricular arrhythmia in patients with prolonged QT interval during liver transplantation: two cases report [PDF]
Korean Journal of Anesthesiology, 2014 QT interval prolongation is associated with an increased risk of ventricular arrhythmia in various conditions. Cardiac electrophysiologic abnormalities including QT interval prolongation are well documented in patients with advanced liver cirrhosis.
Min-Soo Kim +3 more
doaj +1 more source
Pharmacometabolomic approach to predict QT prolongation in guinea pigs. [PDF]
PLoS ONE, 2013 Drug-induced torsades de pointes (TdP), a life-threatening arrhythmia associated with prolongation of the QT interval, has been a significant reason for withdrawal of several medicines from the market. Prolongation of the QT interval is considered as the
Jeonghyeon Park +8 more
doaj +1 more source
Hepatology, EarlyView., 2022 Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou +13 more
wiley +1 more source