Results 31 to 40 of about 55,181 (324)

Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias [PDF]

, 2016
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for assessment of drug-induced arrhythmias and are being considered for use under the comprehensive in vitro proarrhythmia assay (CiPA).
Blinova, Ksenia, Brock, Mathew, Chan, Dulciana, Chvatal, Stacie, Crumb, William J., Galeotti, Loriano, Hortigon-Vinagre, Maria P., Johannesen, Lars, Lyn-Cook, Beverly, Millard, Daniel, Pang, Li, Ross, James, Smith, Godfrey, Stockbridge, Norman, Stohlman, Jayna, Strauss, David G., Vicente, Jose, Zamora Rodriguez, Victor   +17 more
core   +1 more source

Antimicrobials and QT prolongation [PDF]

Journal of Antimicrobial Chemotherapy, 2017
Solithromycin, a ketolide/macrolide antibiotic, has recently been reported to be free of the expected QT-prolonging effect of macrolides. It appears that its keto substitution provides a structural basis for this observation, as the other two tested ketolides also have minimal QT effect.Among non-cardiovascular therapies, antimicrobials probably carry ...
openaire   +2 more sources

THE WAYS TO ENHANCE SAFETY OF COMBINATIONS OF DRUGS PROLONGING QT INTERVAL IN THE OUT-PATIENT AND POLYCLINIC PRACTICE

Вестник анестезиологии и реаниматологии, 2018
Prolongation of QT interval is a predictor of fatal disorders of cardiac rhythm and sudden death. Side effects of medications is one of the main causes of prolonged QT interval.
E. V. Shikh, Zh. M. Sizova, A. D. Ismagilov, M. A. Vyzhigina   +3 more
doaj   +1 more source

Cancer treatment and drug-induced QT interval prolongation: A review

Consilium Medicum, 2022
Anticancer drugs can cause drug-induced prolongation of the QT interval. Prolongation of the QT interval is a known risk factor and an independent predictor of the development of life-threatening ventricular arrhythmias (polymorphic ventricular ...
Olga D. Ostroumova, Aleksey I. Kochetkov, Valeria A. De   +2 more
doaj   +1 more source

Transient Long QT Development in a Patient with Takotsubo Cardiomyopathy

Journal of Cardiovascular Emergencies, 2016
QT interval prolongation on the electrocardiogram is considered a precursory sign for imminent, potentially lethal ventricular arrhythmias. Beside the inherited condition of long QT syndrome, numerous drugs, certain electrolyte disturbances and early ...
Czuriga Dániel, Szegedi Andrea, Győry Ferenc, Szilágyi Attila, Sipka Sándor, Kertész Attila, Fülöp László, Czuriga István, Péter Andrea, Édes István, Bódi Annamária   +10 more
doaj   +1 more source

Data-driven drug-induced QT prolongation surveillance using adverse reaction signals derived from 12-lead and continuous electrocardiogram data.

PLoS ONE, 2022
Drug-induced QT prolongation is one of the most common side effects of drug use and can cause fatal outcomes such as sudden cardiac arrest. This study adopts the data-driven approach to assess the QT prolongation risk of all the frequently used drugs in ...
Byung Jin Choi, Yeryung Koo, Tae Young Kim, Hong-Seok Lim, Dukyong Yoon   +4 more
doaj   +2 more sources

Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Review

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThe cardiovascular complications of cancer therapeutics are the focus of the burgeoning field of cardio‐oncology. A common challenge in this field is the impact of cancer drugs on cardiac repolarization (ie, QT prolongation) and the potential ...
Andreu Porta‐Sánchez, Cameron Gilbert, Danna Spears, Eitan Amir, Joyce Chan, Kumaraswamy Nanthakumar, Paaladinesh Thavendiranathan   +6 more
doaj   +1 more source

What links BRAF to the heart function? New insights from the cardiotoxicity of BRAF inhibitors in cancer treatment [PDF]

, 2015
The RAS-related signalling cascade has a fundamental role in cell. It activates differentiation and survival. It is particularly important one of its molecules, B-RAF. B-RAF has been a central point for research, especially in melanoma. Indeed, it lacked
BAVETTA, Maria Grazia, BAZAN, Viviana, BRANCATELLI, Giuseppe, BRONTE, Enrico, BRONTE, Fabrizio, BRONTE, Giuseppe, Natoli, C., NOVO, Giuseppina, NOVO, Salvatore, Re, G., RUSSO, Antonio   +10 more
core   +3 more sources

Lifting connections to the r-jet prolongation of the cotangent bundle [PDF]

, 2014
We show that the problem of finding all Mfm -natural operators C : Q "M QJ r T ∗ lifting classical linear connections ∇ on m-manifolds M into classical linear connections CM (∇) on the r-jet prolongation J r T ∗M of the cotangent bundle T ∗M p of M
Mikulski, Włodzimierz M.
core   +1 more source

Sex‐specific activation of SK current by isoproterenol facilitates action potential triangulation and arrhythmogenesis in rabbit ventricles [PDF]

, 2018
Sex has a large influence on cardiac electrophysiological properties. Whether sex differences exist in apamin‐sensitive small conductance Ca2+‐activated K+ (SK) current (IKAS) remains unknown.
Chen, Mu, Chen, Peng-Sheng, Chen, Zhenhui, Everett, Thomas H., IV, Guo, Shuai, Lin, Shien-Fong, Rubart-von der Lohe, Michael, Wang, Zhuo, Weiss, James N., Xu, Dong-Zhu, Yin, Dechun   +10 more
core   +1 more source