Results 81 to 90 of about 136,945 (286)

Creation of a Computational Pipeline to Extract Genes from Quantitative Trait Loci for Diabetes and Obesity [PDF]

open access: yes, 2015
Type 2 Diabetes is a disease of relative insulin deficiency resulting from a combination of insulin resistance and decreased beta-cell function. Over the past several years, over 60 genes have been identified for Type 2 Diabetes in human genome-wide ...
Fox, Joseph
core   +1 more source

Elucidating R‐gene‐mediated resistance to wheat dwarf virus in Triticum aestivum genotypes

open access: yesAnnals of Applied Biology, EarlyView.
This study investigates R‐gene‐mediated resistance to wheat dwarf virus (WDV) among different wheat genotypes. Following inoculation with Psammotettix alienus (leafhoppers) and the subsequent appearance of characteristic symptoms such as yellowing and dwarfing, phenotypic responses were evaluated alongside molecular analyses, including quantification ...
Priyanka Krishnamurthy   +3 more
wiley   +1 more source

The Genetic Basis of Mutation Rate Variation in Yeast. [PDF]

open access: yes, 2018
Mutations are the root source of genetic variation and underlie the process of evolution. Although the rates at which mutations occur vary considerably between species, little is known about differences within species, or the genetic and molecular basis ...
Bloom, Joshua S   +2 more
core   +1 more source

Psychometric and clinical validation of the fear of childbirth questionnaire in a UK population

open access: yesActa Obstetricia et Gynecologica Scandinavica, EarlyView.
The Fear of Childbirth Questionnaire is a psychometrically valid tool, which, alongside clinical conversation, can be used to identify fear of childbirth at levels commensurate with a clinical phobia. Abstract Introduction Severe fear of childbirth (FOC) during pregnancy holds significant implications for maternal mental health, decisions about mode of
Kayleigh Sheen   +7 more
wiley   +1 more source

Serious limitations of the QTL/Microarray approach for QTL gene discovery [PDF]

open access: yesBMC Biology, 2010
Abstract Background It has been proposed that the use of gene expression microarrays in nonrecombinant parental or congenic strains can accelerate the process of isolating individual genes underlying quantitative trait loci (QTL). However, the effectiveness of this approach has not been assessed.
Verdugo, Ricardo A   +3 more
openaire   +5 more sources

Identification and mapping of quantitative resistance to late blight (Phytophthora infestans) in Solanum habrochaites LA1777 [PDF]

open access: yes, 2011
Late blight (Phytophthora infestans) can have devastating effects on tomato production over the whole world. Most of the commercial cultivars of tomato, Solanum lycopersicum, are susceptible.
Bai, Y.   +5 more
core   +2 more sources

Meta‐analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape

open access: yesEpilepsia, EarlyView.
Abstract Objective Despite decades of development in anti‐seizure medications, ~30% of individuals remain refractory to all treatments, and none of the existing therapies are disease modifying. Identifying targets outside the current preclinical paradigm is critically important.
Giovanna L. Durante   +4 more
wiley   +1 more source

QTL mapping in rice

open access: yesTrends in Genetics, 1995
In the past 10 years, interest in applying the tools of molecular genetics to the problem of increasing world rice production has resulted in the generation of two highly saturated, molecular linkage maps of rice, and the localization of numerous genes and quantitative trait loci (QTLs).
S R, McCouch, R W, Doerge
openaire   +2 more sources

Frost tolerance in winter wheat cultivars: different effects of chromosome 5A and association with microsatellite alleles

open access: yesBiologia Plantarum, 2013
Frost tolerance of ten Bulgarian winter wheat (Triticum aestivum L.) cultivars (Milena, Pobeda, Sadovo-1, Enola, Kristal, Laska, Svilena, Russalka, No301 and Lozen) and five foreign cultivars (Mironovskaya 808, Bezostaya-1, Rannaya-12, Skorospelka-35 and
G. Ganeva   +7 more
doaj   +1 more source

LPS resistance of SPRET/Ei mice is mediated by Gilz, encoded by the Tsc22d3 gene on the X chromosome [PDF]

open access: yes, 2013
Natural variation for LPS-induced lethal inflammation in mice is useful for identifying new genes that regulate sepsis, which could form the basis for novel therapies for systemic inflammation in humans.
Beaulieu E   +12 more
core   +2 more sources

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