Results 61 to 70 of about 761 (208)

MethyAnno: An Interpretable Automated Annotation Method Leveraging Multi‐Scale Information and Metric Learning Framework for scDNAm Data

Advanced Science, EarlyView.
MethyAnno enables robust and interpretable annotation of single‐cell DNA methylation data by integrating multi‐scale epigenetic information, bidirectional cross‐attention, and prototype‐based metric learning. The framework resolves rare and novel cell types across datasets while revealing cell‐type‐specific epigenetic signatures associated with disease
Yuhang Jia, Siyu Li, Songming Tang, Keju Gu, Shengquan Chen   +4 more
wiley   +1 more source

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

Advanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka, Azad Farzadfard, Jacob Aunstrup Larsen, Rasmus Krogh Norrild, Federica Saraceno, Celia Fricke, Hossein Mohammad‐Beigi, Ahmed Sadek, Jonas Folke, Susana Aznar, Alexander K. Buell   +10 more
wiley   +1 more source

Generalized functions

, 1964
Volume 1 is devoted to basics of the theory of generalized functions. The first chapter contains main definitions and most important properties of generalized functions as functional on the space of smooth functions with compact support.
Pyatetskii-Shapiro, I I, Gelfand, I M, Graev, M I, Shilov, Georgi E, Vilenkin, N Y   +4 more
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Green's Functions of Non‐Hermitian Systems at Exceptional Deficiency

Advanced Science, EarlyView.
We analyze the responses of a non‐Hermitian lattice system under the condition of exceptional deficiency (ED), when all bands in the system are formed by exceptional points. Using the frequency domain, we identify novel steady‐state responses that root in the broadband super‐Lorentzian Green's function (GF).
Congwei Lu, Guancong Ma
wiley   +1 more source

Closing the Loop: High‐Precision 3D Photofabrication in Living Tissues

Advanced Science, EarlyView.
Writing 3D microstructures inside living tissue demands more than laser access; It demands information. Hierarchical sensing captures thermal and mechanical states across pulse‐train, voxel, and structure timescales, feeding a controller that steers the laser in real time.
Amirbahador Zeynali, Mangirdas Malinauskas, Giuseppe Chirico   +2 more
wiley   +1 more source

Beyond‐Classical Ferroelectric Metamaterials: 3D‐Printed Planar Lattices With Programmable Electro–Thermo–Mechanical Coupling

Advanced Science, EarlyView.
Planar ferroelectric lattices with rationally‐tailored topology and polarization achieve programmable piezoelectric and pyroelectric properties. Analytical modeling, homogenization, and experiments collectively demonstrate enhanced and tunable longitudinal, transverse, and shear piezoelectric responses, together with substantially improved ...
Jiahao Shi, Kang Ju, Haoyu Chen, Valerie Orsat, Agus P. Sasmito, Ali Ahmadi, Abdolhamid Akbarzadeh   +6 more
wiley   +1 more source

An Expertise Transfer Framework For Autonomous Surgical Assistance

Advanced Science, EarlyView.
This study introduces an expertise transfer framework for procedure‐spanning autonomous surgical assistance. By emulating expert logic through hierarchical perception, attention modeling, and knowledge graph‐based decision‐making, the system provides near‐expert surgical view assistance.
Yuan Gao, Guangdi Chu, Wei Jiao, Yuchuan Zhong, Hang Yuan, Chengjun Li, Jinhua Li, Shuxin Wang, Bo Guan, Jianchang Zhao, Lizhi Pan, Haitao Niu, Jianmin Li   +12 more
wiley   +1 more source

Q‐LEAP: Millisecond Hyperdimensional Optimization for Full‐Spectrum Optical Metamaterials

Advanced Science, EarlyView.
Q‐LEAP integrates physics‐informed residual machine learning with factorization‐machine‐encoded quantum annealing to design full‐spectrum optical metamaterials. It explores a 2108 design space and, in a single 2.56 ms annealing step, reaches 85.83% of the theoretical FoM limit, enabling selective 5‐8 µm emission with 3–5 and 8–14 µm suppression and ∼40×
Zikang Guo, Yunwen Wu, Yuhui Guo, Shenghong Ju   +3 more
wiley   +1 more source

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

Advanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee, Chan Ho Jeon, Doyun Kim, Minjae Lee, Minji Kwon, Joon Myong Song   +5 more
wiley   +1 more source

Contents

, 1998
CONTENTS Forum mathematicum (Rights reserved) (-) Inhomogeneous Khintchine–Groshev-type theorems on manifolds over function fields / Das, Sourav (Rights reserved) (-) Rational points in Cantor sets and spectral eigenvalue problem for self ...

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