Results 111 to 120 of about 8,643,122 (251)

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Current Role and Potential of Triple Quadrupole Mass Spectrometry in Biomedical Research and Clinical Applications

Molecules
Mass-spectrometry-based assays nowadays play an essential role in biomedical research and clinical applications. There are different types of commercial mass spectrometers on the market today, and triple quadrupole (QqQ) is one of the time-honored ...
Andreas Tsakalof, Alexey A. Sysoev, Kira V. Vyatkina, Alexander A. Eganov, Nikolay N. Eroshchenko, Alexey N. Kiryushin, Alexey Yu. Adamov, Elena Yu. Danilova, Alexander E. Nosyrev   +8 more
doaj   +1 more source

Water‐Soluble POSS Promotes Concurrent Coalescence and Crosslinking for Multiscale‐Reinforced, Coalescent‐Free Waterborne Coatings

Advanced Science, EarlyView.
Water‐soluble amine‐functionalized polyhedral oligomeric silsesquioxane promotes concurrent latex coalescence and crosslinking, allowing epoxy‐functional particles to form continuous films without added volatile coalescing agents. The resulting multiscale‐reinforced waterborne coatings combine high strength, toughness, optical transparency, scratch ...
Chao Wang, Bin Wu, Lin Li, Yibo Ru, Xiaohe Zhang, Minlong Wang, Ruoyan Yang, Jie An   +7 more
wiley   +1 more source

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source

Observation of tunable accidental bound state in the continuum in silicon nanodisk array

Nanophotonics
We experimentally demonstrate the tuning of accidental bound states in the continuum (A-BICs) in silicon nanodisk arrays. The A-BIC emerges of the destructive interference of multipoles, which are the dominating out-of-plane electric dipole and in-plane ...
Han Yingying, Xiong Lei, Shi Jianping, Li Guangyuan   +3 more
doaj   +1 more source

Gravitational waves effects in a Lorentz–violating scenario

Physics Letters B
This paper focuses on how the production and polarization of gravitational waves are affected by spontaneous Lorentz symmetry breaking, which is driven by a self–interacting vector field.
K.M. Amarilo, M.B. Ferreira Filho, A.A. Araújo Filho, J.A.A.S. Reis   +3 more
doaj   +1 more source

RADIAL MATRIX ELEMENT FOR THE QUADRUPOLE TRANSITION WITH THE MORSE POTENTIAL

, 1952
A general formula for the radial part of the matrix element for the quadrupole transition with the Morse potential is derived using standard methods of analysis. The same methods can also be used to derive an expression for the radial part of the dipole
H. A. Buckmaster
core   +1 more source

Programmable Guest‐Induced 5‐Phase‐Transition Topological Reconstructions of Cobalt Formate Metal–Organic Frameworks

Advanced Science, EarlyView.
A reversible five‐phase topological cycle is achieved in a minimalist cobalt formate metal–organic framework. The amorphous phase functions as a programmable reactive hub, selectively reconstructing into four distinct crystalline architectures through cationic templates, humidity, or CO2.
Zhiyu Tao, Jingjian Li, Jing Ling, Tianxiang Chen, Wing‐Yiu Yu, Cong Lin, Tsz Woon Benedict Lo   +6 more
wiley   +1 more source

Special N-dimensional charged anti-de-Sitter black holes in f(Q) gravitational theory

Physics Letters B
In this study, we introduce a toroidal solution for charged anti-de Sitter black holes in N dimensions within the framework of the quadratic form of f(Q) gravity, employing the coincident gauge condition [1].
G.G.L. Nashed
doaj   +1 more source

Ammonification Process Is Limited by Transformation of Medium Molecular Weight Nitrogenous Organics but Not Hydrolysis of Proteins

Advanced Science, EarlyView.
A multi‐level analytical framework, integrating protein‐level persistence analysis, nontargeted HRMS formula tracking, peptide‐level proteomics, and targeted monomer quantification under varying redox conditions, together with FMO calculations reveal that ammonification is limited by medium molecular weight nitrogenous multimers.
Jing Li, Junjie Qiu, Fan Lü, Hua Zhang, Pinjing He   +4 more
wiley   +1 more source