Results 171 to 180 of about 97,163 (263)

Ion-Ion Chemistry for the Analysis of Biomolecular Ions via Tandem Mass Spectrometry: A Tutorial Review. [PDF]

Annu Rev Anal Chem (Palo Alto Calif)
Horn SA, Ellin NR, McLuckey SA.
europepmc   +1 more source

Discovery of CRBN‐based molecular glue degraders targeting WIZ transcription factor

Bulletin of the Korean Chemical Society, EarlyView.
This work reports the discovery of 9l, a novel cereblon‐based molecular glue degrader which targets the WIZ transcription factor. Compound 9l facilitates WIZ‐CRBN ternary complex formation to degrade WIZ, subsequently inducing γ‐globin expression in HUDEP‐2 cells and highlighting its potential as a sickle cell disease therapy.
Tae‐Jun Kim, Seongu Seong, Jung‐Ae Kim, Taeyeon Kwon, Hyun Jin Kim, Jeong‐Hoon Kim, Jong Yeon Hwang, Jin Hwa Cho, Kyoungmin Choi   +8 more
wiley   +1 more source

Protocol for stable isotope tracing of primary human peripheral blood mononuclear cells. [PDF]

STAR Protoc
Hart SN, Williams H, Inabnet WB, Steiner JP, Jain V, Kern PA, Wood CR, Nikolajczyk BS, Johnson LA.   +8 more
europepmc   +1 more source

Vacancy defect‐induced electron homing breaks phosphodiester bonds for RNA depletion‐driven cancer therapy

BMEMat, EarlyView.
Illustration of 5% S‐vacancy Bi2S3 mediated phosphodiester bonds cleavage in RNA of hepatocellular carcinoma cells, which suppressing ERI3 expression, inhibiting cell proliferation and promoting apoptosis. Abstract Genome‐wide hypertranscription is a hallmark of malignant progression.
Chuncheng Yang, Zehao Shen, Guangming Xiang, Zhe Liu, Huaxin Liu, Jiabei Li, Ao Wang, Yelin Wu, Peiran Zhao, Xingwu Jiang, Jinghan Wang, Xiaoqing Jiang, Wenbo Bu   +12 more
wiley   +1 more source

Peripheral frataxin levels govern long-term clinical progression in Friedreich ataxia. [PDF]

BMJ Neurol Open
Rummey C, Blair IA, Mesaros C, Rojsajjakul T, Dong Y, Wilmot G, Zesiewicz T, Mathews K, Hoyle JC, Seeberger L, Corben LA, Delatycki MB, Finkel RS, Roxburgh RH, Duquette A, Yoon G, Gomez CM, Subramony SH, Perlman S, Mccormack S, Lynch DR.   +20 more
europepmc   +1 more source

β‐1,4‐galactosyltransferase 1 inhibitors modulate cellular N‐glycan profiles

Biotechnology Progress, EarlyView.
Graphical representation of the study workflow used to investigate the effects of known in vitro galactosyltransferase inhibitors on cell culture performance and recombinant IgG galactosylation. Abstract N‐glycosylation is a key post‐translational modification of proteins influencing their physicochemical properties as well as biological activity. This
Jaka Kranjc, Stane Pajk, Marko Anderluh, Anja Pišlar, Matjaž Brinc   +4 more
wiley   +1 more source

Abrupt structural transition in exotic molybdenum isotopes unveils an isospin-symmetric island of inversion. [PDF]

Nat Commun
Ha J, Recchia F, Lenzi SM, Iwasaki H, Dao DD, Nowacki F, Revel A, Aguilera P, de Angelis G, Ash J, Bazin D, Bentley MA, Biswas S, Carollo S, Cortes ML, Elder R, Escudeiro R, Farris P, Gade A, Ginter T, Grinder M, Li J, Napoli DR, Noji S, Pereira J, Pigliapoco S, Pompermaier A, Poves A, Rezynkina K, Sanchez A, Wadsworth R, Weisshaar D.   +31 more
europepmc   +1 more source

Boosting Electron‐Hole Charge Separation in CO2 Photoreduction through Fluoroporphyrin‐Linked Nickel(II)‐Acetylide Frameworks

Carbon Energy, EarlyView.
A NiII‐acetylide framework, H2TFPP‐Ni‐AF, demonstrates outstanding photocatalytic CO2 reduction performance: 13.16 mmol h−1 g−1 of CO with 97.9% selectivity. Synergistic interactions, including d‐p orbital hybridization within NiII‐bis(acetylide) moieties ( − C ≡ C−NiII(PBu3)2 − C ≡ C − ) and the efficient charge transport afforded by π‐conjugated ...
Lifen Chen, Lian Duan, Yidi Wang, Yasuteru Shigeta, Kowit Hengphasatporn, Linli Xu, Wai‐Yeung Wong   +6 more
wiley   +1 more source

Decoding the Metabolic Signatures of Neurodegeneration Diseases: Advances in Mass Spectrometry-Based Metabolomics. [PDF]

Metabolites
Hakim MA, Li L.
europepmc   +1 more source

Porous Carbon Materials for Carbon Dioxide Capture

Carbon Energy, EarlyView.
This work aims to address the current status and challenges associated with the regulation of pore structures, as well as the influence of pore structures on CO2 capture. Systematic quantitative analysis of structure–property relationships, combined with machine learning approaches, can effectively evaluate the contributions of structural ...
Zhifu Liu, Chuhan Fu, Tao Qi, Hui Zhou, Guangping Hao, Yalou Guo, Guoping Hu   +6 more
wiley   +1 more source