Results 191 to 200 of about 117,701 (260)

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Open Systems Pharmacology Community Conference (OSP-CC) Proceedings 2025. [PDF]

open access: yesCPT Pharmacometrics Syst Pharmacol
Cordes H   +35 more
europepmc   +1 more source

Epidemiology of the acute respiratory distress syndrome and the prognostic validity of SpO<sub>2</sub>:FiO<sub>2</sub> under the expanded Global definition. [PDF]

open access: yesCrit Care
Bennett RM   +13 more
europepmc   +1 more source

Relationship between salivary neuropeptide Y and performance under stress: a study on police firearms officers. [PDF]

open access: yesFront Hum Neurosci
Jones MV   +11 more
europepmc   +1 more source

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