Results 231 to 240 of about 891,174 (285)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Core competencies and qualifications of health sciences school managers: a multi-method qualitative study. [PDF]

BMC Med Educ
Doshmangir L, Jorjani M, Khoshdel A, Kabiri N, Haghparast A, Semnanian S, Sadeghifar J, Mahboubi M, Haghdoost A, Somi MH, Aslanabadi S, Rezapour R.   +11 more
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Evaluating call prioritisation discrepancies and Emergency Medical Services resource allocation in the North West province of South Africa. [PDF]

Afr J Emerg Med
Mbatha BN, Sobuwa S, Chule NG.
europepmc   +1 more source

Higher qualifications quarterly : July to September 2011 [PDF]

, 2011

core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

A national benchmarking survey to explore the use of dose error reduction software in adult intensive care units (ICUs). [PDF]

J Intensive Care Soc
Morgan S, Lamont S.
europepmc   +1 more source

The new principal learning qualifications : interim findings from the monitoring of the new level 2 qualifications in 2009 [PDF]

, 2010

core  

Decoding missed nursing care: the power of metaphorical analysis. [PDF]

J Res Nurs
Campbell S.
europepmc   +1 more source