Results 51 to 60 of about 9,681,542 (365)

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

open access: yesFEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile   +8 more
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Discovering qualitative empirical laws [PDF]

open access: yes, 1985
In this paper we describe GLAUBER, an AI system that models the scientific discovery of qualitative empirical laws. We have tested the system on data from the history of early chemistry, and it has rediscovered such concepts as acids, alkalis, and salts,
Fisher, Douglas H.   +3 more
core   +1 more source

Automated high-temporal-resolution multi-element river water monitoring with ICP-MS

open access: yesEnvironmental Sciences Europe
Background Real-time monitoring of multi-element concentrations in rivers is highly desirable due to potential hazardous impacts and a better understanding of geochemical cycles.
Mohamed Harhash   +6 more
doaj   +1 more source

Research design: qualitative, quantitative, and mixed methods approaches

open access: yes, 2003
Nova edicao do conhecido livro sobre metodologia de pesquisa de Creswell. Originalmente pensado no campo da Educacao, o autor ficou muito conhecido tambem em Administracao.
Miguel P Caldas
semanticscholar   +1 more source

Qualitative Analysis of Hydroxyurea

open access: yesDrug Analytical Research, 2020
Hydroxyurea (HU) is a cytostatic agent with antineoplastic activity and it has great clinical efficacy in the treatment of sickle cell disease. HU is part of the National Relation of Essential Medicines of Brazil and despite of its clinical importance, only the Portuguese, American and European Pharmacopoeias present monographs for this medicine.
Santos, Stéfanno Souza   +3 more
openaire   +8 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Sharing Qualitative and Qualitative Longitudinal Data in the UK: Archiving Strategies and Development [PDF]

open access: yes, 2011
Over the past two decades significant developments have occurred in the archiving of qualitative data in the UK. The first national archive for qualitative resources, Qualidata, was established in 1994.
Bishop, Libby, Neale, Bren
core  

Superconductors as giant atoms: qualitative aspects [PDF]

open access: yes, 2003
When the Fermi level is near the top of a band the carriers (holes) are maximally dressed by electron-ion and electron-electron interactions. The theory of hole superconductivity predicts that only in that case can superconductivity occur, and that it is
Hirsch, J. E.
core   +2 more sources

The Gender Dimension of Women’s Lingual Behaviorin Polylingual Families and Partnerships

open access: yesПолітичні дослідження, 2021
The typical studies on national and language issues have a focus on macro-level of social structure. Despite the large number of available studies on gender inequality, in Ukraine in particular, the issue of including the gender aspect in the contextof ...
Anastasiia Molotsiian   +1 more
doaj   +1 more source

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