Results 51 to 60 of about 5,197,067 (298)

Qualitative Psychology Nexus, Vol. VII: Qualitative Approaches in the Field of Psychology

open access: yes, 2008
Volume 7 of Qualitative Psychology Nexus contains contribution to the meeting 2008 of the Center for Qualitative Psychology in Erkner/Berlin. The general topic was to discuss the importance of qualitative approaches in psychology.
Huber, Günter L.   +13 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

The Gender Dimension of Women’s Lingual Behaviorin Polylingual Families and Partnerships

open access: yesПолітичні дослідження, 2021
The typical studies on national and language issues have a focus on macro-level of social structure. Despite the large number of available studies on gender inequality, in Ukraine in particular, the issue of including the gender aspect in the contextof ...
Anastasiia Molotsiian   +1 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

RENDRE COMPTE DES COLLABORATIONS ONG -ENTREPRISES PAR LA DIFFUSION D’INFORMATIONS SOCIÉTALES.

open access: yesRevue d'Économie & de Gestion
Le début du XXIe siècle est marqué par le rapprochement entre les entreprises et les ONG. En effet, les rapports entre les deux acteurs se sont adoucis, quittant des postures antagonistes ou d’ignorance pour donner lieu à des collaborations qui ...
Qualitative research.
doaj   +2 more sources

Psychological meanings reported by patients with Graves’ Disease in hyperthyroidism but without ophthalmopathy about their quotidian life: A qualitative study conducted in a Brazilian university specialized outpatient service

open access: yesEuropean Psychiatry
Introduction To handle well clinical treatments, it is crucial to know the expectations of patients who seek help. We need to ask ourselves: how do patients interpret subjectively their diagnosis, treatments, and self-care?
L. S. Valladão   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Pluralism in qualitative research: the impact of different researchers and qualitative approaches on the analysis of qualitative data [PDF]

open access: yesQualitative Research, 2010
Qualitative approaches to research in psychology and the social sciences are increasingly used. The variety of approaches incorporates different epistemologies, theoretical traditions and practices with associated analysis techniques spanning a range of theoretical and empirical frameworks.
Holt, Amanda   +6 more
openaire   +4 more sources

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