Results 121 to 130 of about 27,292,892 (271)
British Journal of Clinical Pharmacology, EarlyView.Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza +12 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Improvement in medication adherence is often proposed as a potential advantage of pharmacogenetic‐guided prescribing over a traditional one‐size‐fits‐all approach. This paper provides a review of the published literature and presents the findings of studies that measure adherence to medication as an outcome of pharmacogenetic‐informed care, or that ...
Lucy Galloway +2 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim Increasing use of oral antitumour therapeutics (OAT) in paediatrics is associated with numerous advantages, but also with error‐prone aspects. Based on the randomized AMBORA trial including adults treated with various OAT, we developed a tailored pharmacological/pharmaceutical care programme for children and their caregivers during OAT treatment ...
Phyllis Lensker +4 more
wiley +1 more source
Re-using Qualitative Research Data: a Personal Account
Forum: Qualitative Social Research, 2000 This paper describes three experiences of reanalysing data. The first is the re-use of data I have collected myself, primarily the much-used dataset "Family and Work Conditions before 1918", collected in the early 1970s, and the extent to which this has ...
Paul Thompson
doaj
When meta‐analyses mislead: Promises and pitfalls in teratology counselling
British Journal of Clinical Pharmacology, EarlyView.Meta‐analysis has become a central tool for evidence synthesis in clinical teratology, offering the promise of increased statistical power, earlier signal detection and consolidated guidance for teratology counselling. When conducted rigorously and interpreted carefully, pooled analyses can provide clinicians with a structured basis for risk ...
Yusuf Cem Kaplan, Nusret Uysal
wiley +1 more source
The Interpretive Turn: History, Memory, and Storage in Qualitative Research
Forum: Qualitative Social Research, 2005 This article reviews the field of qualitative inquiry, identifying three conceptual breaks: the "orthodox consensus" of positivism which conceives the social world as a collection of external facts and attempts to eliminate bias and subjectivity; post ...
Véronique Mottier
doaj
British Journal of Clinical Pharmacology, EarlyView.Aims Regulatory inconsistency across Africa causes duplicative assessments, prolonged approvals, and delayed medical access. To inform the African Medicines Agency (AMA), the African Medicines Regulatory Harmonisation (AMRH) piloted Africa's first continental scientific evaluation of human medicinal products.
Alex Juma Ismail +4 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim Londamocitinib (AZD4604) is an inhaled, selective Janus kinase 1 (JAK1) inhibitor in development for asthma. This open‐label, two‐part, phase I clinical study (NCT06157255) used a radiolabelled microtracer approach to evaluate the absolute bioavailability and the absorption, distribution, metabolism and excretion (ADME) of inhaled londamocitinib ...
Camille Riff +12 more
wiley +1 more source
Preserve Scientific Electronic Journals: A Study of Archiving Initiatives [PDF]
, 2008 This paper seeks to review the archiving initiatives of scientific journals created and supported by various organizations or institutions. A review of nine archiving initiatives including JSTOR, Portico, E-Print Repositories, Open Access Model, LOCKSS ...
Galyani Moghaddam, Golnessa
core
British Journal of Clinical Pharmacology, EarlyView.Aim This study aimed to describe the pharmacokinetics (PK) of levetiracetam (LEV) in term neonates treated for neonatal seizures secondary to hypoxic–ischemic encephalopathy (HIE). Methods Fifteen neonates were included and received a loading dose ranging from 30 to 60 mg/kg followed by eight maintenance doses corresponding to one‐fourth of the loading
Léo Mimram +9 more
wiley +1 more source