Results 31 to 40 of about 9,269,669 (296)

Nature documentaries and saving nature: Reflections on the new Netflix series Our Planet

open access: yesPeople and Nature, 2019
Netflix recently launched its high‐profile nature documentary Our Planet. Voiced by Sir David Attenborough in English (with Salma Hayek, Penelope Cruz and other Hollywood actors voicing versions simultaneously released in 10 other languages), Netflix are
Julia P. G. Jones   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Qualitative studies investigating the effectiveness of stroke rehabilitation - methodological approaches and perspectives / Qualitative Studien zur Wirkung therapeutischer Interventionen – methodische Zugänge und Perspektiven am Beispiel Schlaganfallrehabilitation

open access: yesInternational Journal of Health Professions, 2014
The article focuses on topics, approaches, and methodological perspectives of qualitative intervention research developing within an experimental science-oriented research environment.
Hansen Hilke
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Methods for Quality Assessment of Window View

open access: yesLand
This paper summarises findings from two workshops evaluating a series of views in various settings by an interdisciplinary group of experts. In the first one (Trondheim, June 2022), ten experts visited and assessed views from nine rooms.
Barbara Szybinska Matusiak   +9 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Qualitative Case Study: A Pilot Program to Improve the Integration of Care in a Vulnerable Inner-City Community

open access: yesInternational Journal of Integrated Care, 2022
Introduction: There is a strong correlation between vulnerable populations and poor health outcomes. Growing evidence suggests that person-centred interventions using ‘link workers’ can support communities to navigate and engage with health and community
Margaret Frances Williamson   +4 more
doaj   +1 more source

Qualitative Psychology Nexus, Vol. VII: Qualitative Approaches in the Field of Psychology

open access: yes, 2008
Volume 7 of Qualitative Psychology Nexus contains contribution to the meeting 2008 of the Center for Qualitative Psychology in Erkner/Berlin. The general topic was to discuss the importance of qualitative approaches in psychology.
Huber, Günter L.   +13 more
core   +1 more source

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