Results 51 to 60 of about 14,591,115 (284)

Designing the Evolutionary Model of Iran's Transition to Digital Economy [PDF]

open access: yesFaslnāmah-i Pizhūhish/Nāmah-i Iqtisādī, 2018
Nowadays, digitalization of economy in order to achieve productivity enhancement, improvement of economic growth and job creation has become one of dominant approaches in most countries all over the world. Considering the traditional structures governing
Mohammad Ali Moradi   +1 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

CRITERIA OF THE ESTIMATION OF EFFICIENCY OF INNOVATIONS IN TRANSPORT BRANCH

open access: yesМодернизация, инновация, развитие, 2016
Efficiency of innovations in any economy branch, transportation included, may be assessed on the basis of qualitative and quantitative indices. Innovation efficiency assessment methods and systems valid for the transportation branch are discussed ...
N. A. Borodina
doaj  

Choosing the Path of Leadership in Occupational Therapy

open access: yesOpen Journal of Occupational Therapy, 2014
Leadership is vital to the success and sustainability of any group, organization, or profession. Using a qualitative phenomenological methodology, consistent with interpretative phenomenological analysis, this study examines why occupational therapists ...
Clark Patrick Heard D.OT Reg. (Ont.)
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Informal Leadership in the Clinical Setting: Occupational Therapist Perspectives

open access: yesOpen Journal of Occupational Therapy, 2018
Background: Leadership is vital to clinical, organizational, and professional success. This has compelled a high volume of research primarily related to formal leadership concepts.
Clark Patrick Heard   +4 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Conveying hope in consultations with patients with life-threatening diseases: the balance between supporting and challenging the patient

open access: yesScandinavian Journal of Primary Health Care, 2017
Objective: There is limited knowledge about the communication of hope and denial in consultations with patients with life-threatening diseases on a practical level.
Anne Werner, Sissel Steihaug
doaj   +1 more source

El proceso de una investigación cualitativa longitudinal sobre la transición a la maternidad y paternidad en España

open access: yesEMPIRIA: Revista de Metodología de Ciencias Sociales, 2018
Se expone el proceso metodológico de una investigación cualitativa longitudinal y colaborativa sobre la transición a la maternidad y paternidad en España.
Carmen Botía‐Morillas   +1 more
doaj   +1 more source

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